Cytodiagnosis of coexistence of leukemic infiltration and extramedullary hematopoiesis in a cervical lymph node, in T cell leukemia patient
Extramedullary hematopoiesis (EMH) is a compensatory mechanism that occurs when the marrow is unable to maintain sufficient red cell mass. EMH generally occurs in the patients with deficient bone marrow hematopoiesis secondary to either peripheral red cell destruction or marrow replacement. Although...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Journal of Cytology |
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| Online Access: | http://www.jcytol.org/article.asp?issn=0970-9371;year=2018;volume=35;issue=3;spage=189;epage=192;aulast=Bothale |
| _version_ | 1818994241937866752 |
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| author | Akanksha Bothale Kalpana Bothale Sadhana Mahore Trupti Dongre |
| author_facet | Akanksha Bothale Kalpana Bothale Sadhana Mahore Trupti Dongre |
| author_sort | Akanksha Bothale |
| collection | DOAJ |
| description | Extramedullary hematopoiesis (EMH) is a compensatory mechanism that occurs when the marrow is unable to maintain sufficient red cell mass. EMH generally occurs in the patients with deficient bone marrow hematopoiesis secondary to either peripheral red cell destruction or marrow replacement. Although EMH is known to occur in agnogenic myeloid metaplasia with myelofibrosis, chronic myelogenous leukemia, thalassemia, and infiltrative disorders, such as lymphomas, it is rare in acute leukemias. EMH is most commonly seen in the liver and spleen as a diffuse lesion. The involvement of lymph nodes in leukemia and EMH is known; however, to the best of our knowledge, the occurrence of both in the same lymph node has been reported in a single case report. Our case may be the second most rare case of coexistence of infiltration by leukemic lymphoblasts and EMH in the same lymph node detected on FNAC. EMH should be considered in the differential diagnosis of patients with bone marrow disorders and mass lesions in extramedullary sites. |
| first_indexed | 2024-12-20T20:54:50Z |
| format | Article |
| id | doaj.art-6a67c54f76354ece8cbeea05354edbf4 |
| institution | Directory Open Access Journal |
| issn | 0970-9371 |
| language | English |
| last_indexed | 2024-12-20T20:54:50Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Cytology |
| spelling | doaj.art-6a67c54f76354ece8cbeea05354edbf42022-12-21T19:26:51ZengWolters Kluwer Medknow PublicationsJournal of Cytology0970-93712018-01-0135318919210.4103/0970-9371.232256Cytodiagnosis of coexistence of leukemic infiltration and extramedullary hematopoiesis in a cervical lymph node, in T cell leukemia patientAkanksha BothaleKalpana BothaleSadhana MahoreTrupti DongreExtramedullary hematopoiesis (EMH) is a compensatory mechanism that occurs when the marrow is unable to maintain sufficient red cell mass. EMH generally occurs in the patients with deficient bone marrow hematopoiesis secondary to either peripheral red cell destruction or marrow replacement. Although EMH is known to occur in agnogenic myeloid metaplasia with myelofibrosis, chronic myelogenous leukemia, thalassemia, and infiltrative disorders, such as lymphomas, it is rare in acute leukemias. EMH is most commonly seen in the liver and spleen as a diffuse lesion. The involvement of lymph nodes in leukemia and EMH is known; however, to the best of our knowledge, the occurrence of both in the same lymph node has been reported in a single case report. Our case may be the second most rare case of coexistence of infiltration by leukemic lymphoblasts and EMH in the same lymph node detected on FNAC. EMH should be considered in the differential diagnosis of patients with bone marrow disorders and mass lesions in extramedullary sites.http://www.jcytol.org/article.asp?issn=0970-9371;year=2018;volume=35;issue=3;spage=189;epage=192;aulast=BothaleExtramedullary hematopoiesis (EMH)fine-needle aspiration cytology (FNAC)leukemialeukemic infiltrate |
| spellingShingle | Akanksha Bothale Kalpana Bothale Sadhana Mahore Trupti Dongre Cytodiagnosis of coexistence of leukemic infiltration and extramedullary hematopoiesis in a cervical lymph node, in T cell leukemia patient Journal of Cytology Extramedullary hematopoiesis (EMH) fine-needle aspiration cytology (FNAC) leukemia leukemic infiltrate |
| title | Cytodiagnosis of coexistence of leukemic infiltration and extramedullary hematopoiesis in a cervical lymph node, in T cell leukemia patient |
| title_full | Cytodiagnosis of coexistence of leukemic infiltration and extramedullary hematopoiesis in a cervical lymph node, in T cell leukemia patient |
| title_fullStr | Cytodiagnosis of coexistence of leukemic infiltration and extramedullary hematopoiesis in a cervical lymph node, in T cell leukemia patient |
| title_full_unstemmed | Cytodiagnosis of coexistence of leukemic infiltration and extramedullary hematopoiesis in a cervical lymph node, in T cell leukemia patient |
| title_short | Cytodiagnosis of coexistence of leukemic infiltration and extramedullary hematopoiesis in a cervical lymph node, in T cell leukemia patient |
| title_sort | cytodiagnosis of coexistence of leukemic infiltration and extramedullary hematopoiesis in a cervical lymph node in t cell leukemia patient |
| topic | Extramedullary hematopoiesis (EMH) fine-needle aspiration cytology (FNAC) leukemia leukemic infiltrate |
| url | http://www.jcytol.org/article.asp?issn=0970-9371;year=2018;volume=35;issue=3;spage=189;epage=192;aulast=Bothale |
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