Long-term economic evaluation of the recombinant Mycobacterium tuberculosis fusion protein (EC) test for the diagnosis of Mycobacterium tuberculosis infection
Background: Tuberculosis continues to be a significant global burden. Purified protein derivative of tuberculin (TB-PPD) is one type of tuberculin skin test (TST) and is used commonly for the auxiliary diagnosis of tuberculosis. The recombinant Mycobacterium tuberculosis fusion protein (EC) test is...
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1161526/full |
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| author | Sha Diao Sha Diao Sha Diao Sha Diao Zheng Liu Zheng Liu Zheng Liu Zheng Liu Zheng Liu Dan Liu Dan Liu Dan Liu Dan Liu Dan Liu Xiao Cheng Xiao Cheng Xiao Cheng Xiao Cheng Linan Zeng Linan Zeng Linan Zeng Linan Zeng Xue-Feng Jiao Xue-Feng Jiao Xue-Feng Jiao Xue-Feng Jiao Zhe Chen Zhe Chen Zhe Chen Zhe Chen Zhe Chen Xiaofeng Ni Xiaofeng Ni Xiaofeng Ni Xiaofeng Ni Siyi He Siyi He Siyi He Siyi He Siyi He Bin Wu Deying Kang Chaomin Wan Chaomin Wan Rongsheng Zhao Huiqing Wang Lingli Zhang Lingli Zhang Lingli Zhang Lingli Zhang Lingli Zhang |
| author_facet | Sha Diao Sha Diao Sha Diao Sha Diao Zheng Liu Zheng Liu Zheng Liu Zheng Liu Zheng Liu Dan Liu Dan Liu Dan Liu Dan Liu Dan Liu Xiao Cheng Xiao Cheng Xiao Cheng Xiao Cheng Linan Zeng Linan Zeng Linan Zeng Linan Zeng Xue-Feng Jiao Xue-Feng Jiao Xue-Feng Jiao Xue-Feng Jiao Zhe Chen Zhe Chen Zhe Chen Zhe Chen Zhe Chen Xiaofeng Ni Xiaofeng Ni Xiaofeng Ni Xiaofeng Ni Siyi He Siyi He Siyi He Siyi He Siyi He Bin Wu Deying Kang Chaomin Wan Chaomin Wan Rongsheng Zhao Huiqing Wang Lingli Zhang Lingli Zhang Lingli Zhang Lingli Zhang Lingli Zhang |
| author_sort | Sha Diao |
| collection | DOAJ |
| description | Background: Tuberculosis continues to be a significant global burden. Purified protein derivative of tuberculin (TB-PPD) is one type of tuberculin skin test (TST) and is used commonly for the auxiliary diagnosis of tuberculosis. The recombinant Mycobacterium tuberculosis fusion protein (EC) test is a new test developed in China.Objective: Evaluate the long-term economic implications of using the EC test compared with the TB-PPD test to provide a reference for clinical decision-making.Methods: The target population was people at a high risk persons of being infected with Mycobacterium tuberculosis. The outcome indicator was quality-adjusted life years (QALY). A cost–utility analysis was used to evaluate the long-term economic implications of using the EC test compared with the TB-PPD test. We employed a decision tree–Markov model from the perspective of the whole society within 77 years.Results: Compared with the TB-PPD test, the EC test had a lower cost but higher QALY. The incremental cost–utility ratio was −119,800.7381 CNY/QALY. That is, for each additional QALY, the EC test could save 119,800.7381 CNY: the EC test was more economical than the TB-PPD test.Conclusion: Compared with the TB-PPD test, the EC test would be more economical in the long term for the diagnosis of M. tuberculosis infection according our study. |
| first_indexed | 2024-04-09T12:31:17Z |
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| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-09T12:31:17Z |
| publishDate | 2023-05-01 |
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| series | Frontiers in Pharmacology |
| spelling | doaj.art-6a68aec3e51848e5abeecc006df393f02023-05-16T04:38:47ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-05-011410.3389/fphar.2023.11615261161526Long-term economic evaluation of the recombinant Mycobacterium tuberculosis fusion protein (EC) test for the diagnosis of Mycobacterium tuberculosis infectionSha Diao0Sha Diao1Sha Diao2Sha Diao3Zheng Liu4Zheng Liu5Zheng Liu6Zheng Liu7Zheng Liu8Dan Liu9Dan Liu10Dan Liu11Dan Liu12Dan Liu13Xiao Cheng14Xiao Cheng15Xiao Cheng16Xiao Cheng17Linan Zeng18Linan Zeng19Linan Zeng20Linan Zeng21Xue-Feng Jiao22Xue-Feng Jiao23Xue-Feng Jiao24Xue-Feng Jiao25Zhe Chen26Zhe Chen27Zhe Chen28Zhe Chen29Zhe Chen30Xiaofeng Ni31Xiaofeng Ni32Xiaofeng Ni33Xiaofeng Ni34Siyi He35Siyi He36Siyi He37Siyi He38Siyi He39Bin Wu40Deying Kang41Chaomin Wan42Chaomin Wan43Rongsheng Zhao44Huiqing Wang45Lingli Zhang46Lingli Zhang47Lingli Zhang48Lingli Zhang49Lingli Zhang50Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaEvidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaNMPA Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaEvidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaEvidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaNMPA Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaWest China School of Medicine, Sichuan University, Chengdu, ChinaEvidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaEvidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaNMPA Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaWest China School of Pharmacy, Sichuan University, Chengdu, ChinaEvidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaEvidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaNMPA Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaEvidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaEvidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaNMPA Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaEvidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaEvidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaNMPA Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaEvidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaEvidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaNMPA Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaWest China School of Pharmacy, Sichuan University, Chengdu, ChinaEvidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaEvidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaNMPA Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaDepartment of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, ChinaEvidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaNMPA Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaWest China School of Pharmacy, Sichuan University, Chengdu, ChinaDepartment of Pharmacy, Renji Hospital Affiliated with the School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaChinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China0Department of Pharmacy, Peking University Third Hospital, Beijing, China1Medical Simulation Centre, West China Second University Hospital, Sichuan University, Chengdu, ChinaDepartment of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, ChinaEvidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, ChinaNMPA Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaChinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu, ChinaBackground: Tuberculosis continues to be a significant global burden. Purified protein derivative of tuberculin (TB-PPD) is one type of tuberculin skin test (TST) and is used commonly for the auxiliary diagnosis of tuberculosis. The recombinant Mycobacterium tuberculosis fusion protein (EC) test is a new test developed in China.Objective: Evaluate the long-term economic implications of using the EC test compared with the TB-PPD test to provide a reference for clinical decision-making.Methods: The target population was people at a high risk persons of being infected with Mycobacterium tuberculosis. The outcome indicator was quality-adjusted life years (QALY). A cost–utility analysis was used to evaluate the long-term economic implications of using the EC test compared with the TB-PPD test. We employed a decision tree–Markov model from the perspective of the whole society within 77 years.Results: Compared with the TB-PPD test, the EC test had a lower cost but higher QALY. The incremental cost–utility ratio was −119,800.7381 CNY/QALY. That is, for each additional QALY, the EC test could save 119,800.7381 CNY: the EC test was more economical than the TB-PPD test.Conclusion: Compared with the TB-PPD test, the EC test would be more economical in the long term for the diagnosis of M. tuberculosis infection according our study.https://www.frontiersin.org/articles/10.3389/fphar.2023.1161526/fullrecombinant Mycobacterium tuberculosis fusion protein (EC)purified protein derivative of tuberculin (TB-PPD)Mycobacterium tuberculosis infectiondecision tree-markov modelcost-utility |
| spellingShingle | Sha Diao Sha Diao Sha Diao Sha Diao Zheng Liu Zheng Liu Zheng Liu Zheng Liu Zheng Liu Dan Liu Dan Liu Dan Liu Dan Liu Dan Liu Xiao Cheng Xiao Cheng Xiao Cheng Xiao Cheng Linan Zeng Linan Zeng Linan Zeng Linan Zeng Xue-Feng Jiao Xue-Feng Jiao Xue-Feng Jiao Xue-Feng Jiao Zhe Chen Zhe Chen Zhe Chen Zhe Chen Zhe Chen Xiaofeng Ni Xiaofeng Ni Xiaofeng Ni Xiaofeng Ni Siyi He Siyi He Siyi He Siyi He Siyi He Bin Wu Deying Kang Chaomin Wan Chaomin Wan Rongsheng Zhao Huiqing Wang Lingli Zhang Lingli Zhang Lingli Zhang Lingli Zhang Lingli Zhang Long-term economic evaluation of the recombinant Mycobacterium tuberculosis fusion protein (EC) test for the diagnosis of Mycobacterium tuberculosis infection Frontiers in Pharmacology recombinant Mycobacterium tuberculosis fusion protein (EC) purified protein derivative of tuberculin (TB-PPD) Mycobacterium tuberculosis infection decision tree-markov model cost-utility |
| title | Long-term economic evaluation of the recombinant Mycobacterium tuberculosis fusion protein (EC) test for the diagnosis of Mycobacterium tuberculosis infection |
| title_full | Long-term economic evaluation of the recombinant Mycobacterium tuberculosis fusion protein (EC) test for the diagnosis of Mycobacterium tuberculosis infection |
| title_fullStr | Long-term economic evaluation of the recombinant Mycobacterium tuberculosis fusion protein (EC) test for the diagnosis of Mycobacterium tuberculosis infection |
| title_full_unstemmed | Long-term economic evaluation of the recombinant Mycobacterium tuberculosis fusion protein (EC) test for the diagnosis of Mycobacterium tuberculosis infection |
| title_short | Long-term economic evaluation of the recombinant Mycobacterium tuberculosis fusion protein (EC) test for the diagnosis of Mycobacterium tuberculosis infection |
| title_sort | long term economic evaluation of the recombinant mycobacterium tuberculosis fusion protein ec test for the diagnosis of mycobacterium tuberculosis infection |
| topic | recombinant Mycobacterium tuberculosis fusion protein (EC) purified protein derivative of tuberculin (TB-PPD) Mycobacterium tuberculosis infection decision tree-markov model cost-utility |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1161526/full |
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