Long Non-coding RNA PVT1 as a Prognostic and Therapeutic Target in Pediatric Cancer
In recent decades, biomedical research has focused on understanding the functionality of the human translated genome, which represents a minor part of all genetic information transcribed from the human genome. However, researchers have become aware of the importance of non-coding RNA species that co...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2019.01173/full |
| _version_ | 1818289947887534080 |
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| author | Ariadna Boloix Ariadna Boloix Ariadna Boloix Marc Masanas Carlos Jiménez Roberta Antonelli Aroa Soriano Josep Roma Josep Sánchez de Toledo Soledad Gallego Miguel F. Segura |
| author_facet | Ariadna Boloix Ariadna Boloix Ariadna Boloix Marc Masanas Carlos Jiménez Roberta Antonelli Aroa Soriano Josep Roma Josep Sánchez de Toledo Soledad Gallego Miguel F. Segura |
| author_sort | Ariadna Boloix |
| collection | DOAJ |
| description | In recent decades, biomedical research has focused on understanding the functionality of the human translated genome, which represents a minor part of all genetic information transcribed from the human genome. However, researchers have become aware of the importance of non-coding RNA species that constitute the vast majority of the transcriptome. In addition to their crucial role in tissue development and homeostasis, mounting evidence shows non-coding RNA to be deregulated and functionally contributing to the development and progression of different types of human disease including cancer both in adults and children. Small non-coding RNAs (i.e., microRNA) are in the vanguard of clinical research which revealed that RNA could be used as disease biomarkers or new therapeutic targets. Furthermore, many more expectations have been raised for long non-coding RNAs, by far the largest fraction of non-coding transcripts, and still fewer findings have been translated into clinical applications. In this review, we center on PVT1, a large and complex long non-coding RNA that usually confers oncogenic properties on different tumor types. We focus on the compilation of early advances in the field of pediatric tumors which often lags behind clinical improvements in adult tumors, and provide a rationale to continue studying PVT1 as a possible functional contributor to pediatric malignancies and as a potential prognostic marker or therapeutic target. |
| first_indexed | 2024-12-13T02:20:23Z |
| format | Article |
| id | doaj.art-6a6c8ae09ac24807b512433c7adfa48f |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-13T02:20:23Z |
| publishDate | 2019-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-6a6c8ae09ac24807b512433c7adfa48f2022-12-22T00:02:46ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2019-11-01910.3389/fonc.2019.01173461953Long Non-coding RNA PVT1 as a Prognostic and Therapeutic Target in Pediatric CancerAriadna Boloix0Ariadna Boloix1Ariadna Boloix2Marc Masanas3Carlos Jiménez4Roberta Antonelli5Aroa Soriano6Josep Roma7Josep Sánchez de Toledo8Soledad Gallego9Miguel F. Segura10Group of Translational Research in Child and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona (UAB), Barcelona, SpainInstitut de Ciència de Materials de Barcelona (ICMAB-CSIC), Esfera UAB, Cerdanyola del Vallès, SpainCIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, SpainGroup of Translational Research in Child and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona (UAB), Barcelona, SpainGroup of Translational Research in Child and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona (UAB), Barcelona, SpainGroup of Translational Research in Child and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona (UAB), Barcelona, SpainGroup of Translational Research in Child and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona (UAB), Barcelona, SpainGroup of Translational Research in Child and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona (UAB), Barcelona, SpainGroup of Translational Research in Child and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona (UAB), Barcelona, SpainGroup of Translational Research in Child and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona (UAB), Barcelona, SpainGroup of Translational Research in Child and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona (UAB), Barcelona, SpainIn recent decades, biomedical research has focused on understanding the functionality of the human translated genome, which represents a minor part of all genetic information transcribed from the human genome. However, researchers have become aware of the importance of non-coding RNA species that constitute the vast majority of the transcriptome. In addition to their crucial role in tissue development and homeostasis, mounting evidence shows non-coding RNA to be deregulated and functionally contributing to the development and progression of different types of human disease including cancer both in adults and children. Small non-coding RNAs (i.e., microRNA) are in the vanguard of clinical research which revealed that RNA could be used as disease biomarkers or new therapeutic targets. Furthermore, many more expectations have been raised for long non-coding RNAs, by far the largest fraction of non-coding transcripts, and still fewer findings have been translated into clinical applications. In this review, we center on PVT1, a large and complex long non-coding RNA that usually confers oncogenic properties on different tumor types. We focus on the compilation of early advances in the field of pediatric tumors which often lags behind clinical improvements in adult tumors, and provide a rationale to continue studying PVT1 as a possible functional contributor to pediatric malignancies and as a potential prognostic marker or therapeutic target.https://www.frontiersin.org/article/10.3389/fonc.2019.01173/fullPVT1lncRNAepigenetic8q32pediatric cancer |
| spellingShingle | Ariadna Boloix Ariadna Boloix Ariadna Boloix Marc Masanas Carlos Jiménez Roberta Antonelli Aroa Soriano Josep Roma Josep Sánchez de Toledo Soledad Gallego Miguel F. Segura Long Non-coding RNA PVT1 as a Prognostic and Therapeutic Target in Pediatric Cancer Frontiers in Oncology PVT1 lncRNA epigenetic 8q32 pediatric cancer |
| title | Long Non-coding RNA PVT1 as a Prognostic and Therapeutic Target in Pediatric Cancer |
| title_full | Long Non-coding RNA PVT1 as a Prognostic and Therapeutic Target in Pediatric Cancer |
| title_fullStr | Long Non-coding RNA PVT1 as a Prognostic and Therapeutic Target in Pediatric Cancer |
| title_full_unstemmed | Long Non-coding RNA PVT1 as a Prognostic and Therapeutic Target in Pediatric Cancer |
| title_short | Long Non-coding RNA PVT1 as a Prognostic and Therapeutic Target in Pediatric Cancer |
| title_sort | long non coding rna pvt1 as a prognostic and therapeutic target in pediatric cancer |
| topic | PVT1 lncRNA epigenetic 8q32 pediatric cancer |
| url | https://www.frontiersin.org/article/10.3389/fonc.2019.01173/full |
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