Extracellular vesicles from the inflammatory microenvironment regulate the osteogenic and odontogenic differentiation of periodontal ligament stem cells by miR-758-5p/LMBR1/BMP2/4 axis

Extracellular vesicles from the inflammatory microenvironment regulate the osteogenic and odontogenic differentiation of periodontal ligament stem cells by miR-758-5p/LMBR1/BMP2/4 axis

Abstract Background Extracellular vesicles (EVs) play a key role in constructing a microenvironment that favors the differentiation of stem cells. The present work aimed to determine the molecular mechanisms by which EV derived from inflammatory dental pulp stem cell (iDPSC-EV) influence periodontal...

Full description

Bibliographic Details
Main Authors: Chaoting Yan, Na Li, Tong Xiao, Xiaying Ye, Lin Fu, Yu Ye, Tao Xu, Jinhua Yu
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Journal of Translational Medicine
Subjects:
Extracellular vesicle
Osteogenic and odontogenic differentiation
Periodontal ligament stem cell
Dental pulp stem cell
miRNA sequence
Online Access:https://doi.org/10.1186/s12967-022-03412-9

Similar Items

Similar Items