Quality of life and associated factors among people receiving second-line anti-retroviral therapy in Johannesburg, South Africa
Abstract Background Studies which examine quality of life (QOL) provide important insights that are needed to understand the impacts of HIV/AIDS anti-retroviral treatment (ART), comorbid conditions and other factors on the daily activities of people living with HIV/AIDS (PLH). This study aimed to de...
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-022-07429-9 |
| _version_ | 1811235412534886400 |
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| author | Nomcebo Oratile Mokgethi Nicola Christofides Mercilene Machisa Godspower Akpomiemie Samantha Lalla-Edward |
| author_facet | Nomcebo Oratile Mokgethi Nicola Christofides Mercilene Machisa Godspower Akpomiemie Samantha Lalla-Edward |
| author_sort | Nomcebo Oratile Mokgethi |
| collection | DOAJ |
| description | Abstract Background Studies which examine quality of life (QOL) provide important insights that are needed to understand the impacts of HIV/AIDS anti-retroviral treatment (ART), comorbid conditions and other factors on the daily activities of people living with HIV/AIDS (PLH). This study aimed to determine the inter-relationships between clinical factors, behavioural, socio-demographic variables and QOL among PLH. Methods The secondary analysis used data collected from 293 people living with HIV/AIDS (PLH) receiving second-line ART in Johannesburg in a clinical trial which evaluated the non-inferiority of ritonavir-boosted darunavir (DRV/r 400/100 mg) compared to ritonavir-boosted lopinavir (LPV/r) over a 48 week-period. Physical functioning, cognitive and mental QOL were measured using the Aids Clinical Trial Group questionnaire. Exploratory factor analyses were used to examine the structure, the relationships between and the construct validity of QOL items. Structural equation models which tested the a priori-hypothesised inter-relationships between QOL and other variables were estimated and goodness of fit of the models to the data was assessed. Results Patients on darunavir presented with lower pill burden. Older patients and women were more likely to report lower QOL scores. Pill burden mediated the effects of age, sex and treatment regimen on physical functioning QOL and adverse effects; the effects of age, sex, treatment regimen and adverse effects on cognitive QOL; and the effects of sex on mental QOL. Conclusion QOL among PLH is associated with socio-demographic and clinical factors. Therefore, QOL could be enhanced by considering PLH characteristics, clinical factors such as regimen side-effects profile, management of comorbid conditions and mitigating risks such as potential adverse drug-to-drug interactions among patients on ART. |
| first_indexed | 2024-04-12T11:50:34Z |
| format | Article |
| id | doaj.art-6a6ecd0132dd40b59d404135b2eeba6e |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-12T11:50:34Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-6a6ecd0132dd40b59d404135b2eeba6e2022-12-22T03:34:11ZengBMCBMC Infectious Diseases1471-23342022-05-0122111210.1186/s12879-022-07429-9Quality of life and associated factors among people receiving second-line anti-retroviral therapy in Johannesburg, South AfricaNomcebo Oratile Mokgethi0Nicola Christofides1Mercilene Machisa2Godspower Akpomiemie3Samantha Lalla-Edward4Epidemiology and Biostatistics, WHOSchool of Public Health, Wits UniversitySchool of Public Health, Wits UniversitySchool of Public Health, Wits UniversitySchool of Public Health, Wits UniversityAbstract Background Studies which examine quality of life (QOL) provide important insights that are needed to understand the impacts of HIV/AIDS anti-retroviral treatment (ART), comorbid conditions and other factors on the daily activities of people living with HIV/AIDS (PLH). This study aimed to determine the inter-relationships between clinical factors, behavioural, socio-demographic variables and QOL among PLH. Methods The secondary analysis used data collected from 293 people living with HIV/AIDS (PLH) receiving second-line ART in Johannesburg in a clinical trial which evaluated the non-inferiority of ritonavir-boosted darunavir (DRV/r 400/100 mg) compared to ritonavir-boosted lopinavir (LPV/r) over a 48 week-period. Physical functioning, cognitive and mental QOL were measured using the Aids Clinical Trial Group questionnaire. Exploratory factor analyses were used to examine the structure, the relationships between and the construct validity of QOL items. Structural equation models which tested the a priori-hypothesised inter-relationships between QOL and other variables were estimated and goodness of fit of the models to the data was assessed. Results Patients on darunavir presented with lower pill burden. Older patients and women were more likely to report lower QOL scores. Pill burden mediated the effects of age, sex and treatment regimen on physical functioning QOL and adverse effects; the effects of age, sex, treatment regimen and adverse effects on cognitive QOL; and the effects of sex on mental QOL. Conclusion QOL among PLH is associated with socio-demographic and clinical factors. Therefore, QOL could be enhanced by considering PLH characteristics, clinical factors such as regimen side-effects profile, management of comorbid conditions and mitigating risks such as potential adverse drug-to-drug interactions among patients on ART.https://doi.org/10.1186/s12879-022-07429-9Quality of lifeAnti-retroviral treatmentHIV drug effectsSouth AfricaDarunavir |
| spellingShingle | Nomcebo Oratile Mokgethi Nicola Christofides Mercilene Machisa Godspower Akpomiemie Samantha Lalla-Edward Quality of life and associated factors among people receiving second-line anti-retroviral therapy in Johannesburg, South Africa BMC Infectious Diseases Quality of life Anti-retroviral treatment HIV drug effects South Africa Darunavir |
| title | Quality of life and associated factors among people receiving second-line anti-retroviral therapy in Johannesburg, South Africa |
| title_full | Quality of life and associated factors among people receiving second-line anti-retroviral therapy in Johannesburg, South Africa |
| title_fullStr | Quality of life and associated factors among people receiving second-line anti-retroviral therapy in Johannesburg, South Africa |
| title_full_unstemmed | Quality of life and associated factors among people receiving second-line anti-retroviral therapy in Johannesburg, South Africa |
| title_short | Quality of life and associated factors among people receiving second-line anti-retroviral therapy in Johannesburg, South Africa |
| title_sort | quality of life and associated factors among people receiving second line anti retroviral therapy in johannesburg south africa |
| topic | Quality of life Anti-retroviral treatment HIV drug effects South Africa Darunavir |
| url | https://doi.org/10.1186/s12879-022-07429-9 |
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