Regulatory roles of ferroptosis-related non-coding RNAs and their research progress in urological malignancies
Ferroptosis is a new type of cell death characterized by damage to the intracellular microenvironment, which causes the accumulation of lipid hydroperoxide and reactive oxygen species to cause cytotoxicity and regulated cell death. Non-coding RNAs (ncRNAs) play an important role in gene expression a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2023.1133020/full |
| _version_ | 1811161619463405568 |
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| author | Shijin Wang Bowen Jiang Deqian Xie Xiunan Li Guangzhen Wu |
| author_facet | Shijin Wang Bowen Jiang Deqian Xie Xiunan Li Guangzhen Wu |
| author_sort | Shijin Wang |
| collection | DOAJ |
| description | Ferroptosis is a new type of cell death characterized by damage to the intracellular microenvironment, which causes the accumulation of lipid hydroperoxide and reactive oxygen species to cause cytotoxicity and regulated cell death. Non-coding RNAs (ncRNAs) play an important role in gene expression at the epigenetic, transcriptional, and post-transcriptional levels through interactions with different DNAs, RNAs, or proteins. Increasing evidence has shown that ferroptosis-related ncRNAs are closely related to the occurrence and progression of several diseases, including urological malignancies. Recently, the role of ferroptosis-associated ncRNAs (long non-coding RNAs, micro RNAs, and circular RNAs) in the occurrence, drug resistance, and prognosis of urological malignancies has attracted widespread attention. However, this has not yet been addressed systematically. In this review, we discuss this issue as much as possible to expand the knowledge and understanding of urological malignancies to provide new ideas for exploring the diagnosis and treatment of urological malignancies in the future. Furthermore, we propose some challenges in the clinical application of ferroptosis-associated ncRNAs. |
| first_indexed | 2024-04-10T06:17:21Z |
| format | Article |
| id | doaj.art-6a6f9ae400bc4324a9f2153854323dce |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-10T06:17:21Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-6a6f9ae400bc4324a9f2153854323dce2023-03-02T05:59:46ZengFrontiers Media S.A.Frontiers in Genetics1664-80212023-03-011410.3389/fgene.2023.11330201133020Regulatory roles of ferroptosis-related non-coding RNAs and their research progress in urological malignanciesShijin WangBowen JiangDeqian XieXiunan LiGuangzhen WuFerroptosis is a new type of cell death characterized by damage to the intracellular microenvironment, which causes the accumulation of lipid hydroperoxide and reactive oxygen species to cause cytotoxicity and regulated cell death. Non-coding RNAs (ncRNAs) play an important role in gene expression at the epigenetic, transcriptional, and post-transcriptional levels through interactions with different DNAs, RNAs, or proteins. Increasing evidence has shown that ferroptosis-related ncRNAs are closely related to the occurrence and progression of several diseases, including urological malignancies. Recently, the role of ferroptosis-associated ncRNAs (long non-coding RNAs, micro RNAs, and circular RNAs) in the occurrence, drug resistance, and prognosis of urological malignancies has attracted widespread attention. However, this has not yet been addressed systematically. In this review, we discuss this issue as much as possible to expand the knowledge and understanding of urological malignancies to provide new ideas for exploring the diagnosis and treatment of urological malignancies in the future. Furthermore, we propose some challenges in the clinical application of ferroptosis-associated ncRNAs.https://www.frontiersin.org/articles/10.3389/fgene.2023.1133020/fullferroptosisnon-coding RNAsurological oncologybladder cancerprostate cancerkidney cancer |
| spellingShingle | Shijin Wang Bowen Jiang Deqian Xie Xiunan Li Guangzhen Wu Regulatory roles of ferroptosis-related non-coding RNAs and their research progress in urological malignancies Frontiers in Genetics ferroptosis non-coding RNAs urological oncology bladder cancer prostate cancer kidney cancer |
| title | Regulatory roles of ferroptosis-related non-coding RNAs and their research progress in urological malignancies |
| title_full | Regulatory roles of ferroptosis-related non-coding RNAs and their research progress in urological malignancies |
| title_fullStr | Regulatory roles of ferroptosis-related non-coding RNAs and their research progress in urological malignancies |
| title_full_unstemmed | Regulatory roles of ferroptosis-related non-coding RNAs and their research progress in urological malignancies |
| title_short | Regulatory roles of ferroptosis-related non-coding RNAs and their research progress in urological malignancies |
| title_sort | regulatory roles of ferroptosis related non coding rnas and their research progress in urological malignancies |
| topic | ferroptosis non-coding RNAs urological oncology bladder cancer prostate cancer kidney cancer |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2023.1133020/full |
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