Whole genome sequence analysis of blood lipid levels in >66,000 individuals
Although the common genetic variants contributing to blood lipid levels have been studied, the contribution of rare variants is less understood. Here, the authors perform a rare coding and noncoding variant association study of blood lipid levels using whole genome sequencing data.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33510-7 |
| _version_ | 1811238849493336064 |
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| author | Margaret Sunitha Selvaraj Xihao Li Zilin Li Akhil Pampana David Y. Zhang Joseph Park Stella Aslibekyan Joshua C. Bis Jennifer A. Brody Brian E. Cade Lee-Ming Chuang Ren-Hua Chung Joanne E. Curran Lisa de las Fuentes Paul S. de Vries Ravindranath Duggirala Barry I. Freedman Mariaelisa Graff Xiuqing Guo Nancy Heard-Costa Bertha Hidalgo Chii-Min Hwu Marguerite R. Irvin Tanika N. Kelly Brian G. Kral Leslie Lange Xiaohui Li Martin Lisa Steven A. Lubitz Ani W. Manichaikul Preuss Michael May E. Montasser Alanna C. Morrison Take Naseri Jeffrey R. O’Connell Nicholette D. Palmer Patricia A. Peyser Muagututia S. Reupena Jennifer A. Smith Xiao Sun Kent D. Taylor Russell P. Tracy Michael Y. Tsai Zhe Wang Yuxuan Wang Wei Bao John T. Wilkins Lisa R. Yanek Wei Zhao Donna K. Arnett John Blangero Eric Boerwinkle Donald W. Bowden Yii-Der Ida Chen Adolfo Correa L. Adrienne Cupples Susan K. Dutcher Patrick T. Ellinor Myriam Fornage Stacey Gabriel Soren Germer Richard Gibbs Jiang He Robert C. Kaplan Sharon L. R. Kardia Ryan Kim Charles Kooperberg Ruth J. F. Loos Karine A Viaud-Martinez Rasika A. Mathias Stephen T. McGarvey Braxton D. Mitchell Deborah Nickerson Kari E. North Bruce M. Psaty Susan Redline Alexander P. Reiner Ramachandran S. Vasan Stephen S. Rich Cristen Willer Jerome I. Rotter Daniel J. Rader Xihong Lin NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium Gina M. Peloso Pradeep Natarajan |
| author_facet | Margaret Sunitha Selvaraj Xihao Li Zilin Li Akhil Pampana David Y. Zhang Joseph Park Stella Aslibekyan Joshua C. Bis Jennifer A. Brody Brian E. Cade Lee-Ming Chuang Ren-Hua Chung Joanne E. Curran Lisa de las Fuentes Paul S. de Vries Ravindranath Duggirala Barry I. Freedman Mariaelisa Graff Xiuqing Guo Nancy Heard-Costa Bertha Hidalgo Chii-Min Hwu Marguerite R. Irvin Tanika N. Kelly Brian G. Kral Leslie Lange Xiaohui Li Martin Lisa Steven A. Lubitz Ani W. Manichaikul Preuss Michael May E. Montasser Alanna C. Morrison Take Naseri Jeffrey R. O’Connell Nicholette D. Palmer Patricia A. Peyser Muagututia S. Reupena Jennifer A. Smith Xiao Sun Kent D. Taylor Russell P. Tracy Michael Y. Tsai Zhe Wang Yuxuan Wang Wei Bao John T. Wilkins Lisa R. Yanek Wei Zhao Donna K. Arnett John Blangero Eric Boerwinkle Donald W. Bowden Yii-Der Ida Chen Adolfo Correa L. Adrienne Cupples Susan K. Dutcher Patrick T. Ellinor Myriam Fornage Stacey Gabriel Soren Germer Richard Gibbs Jiang He Robert C. Kaplan Sharon L. R. Kardia Ryan Kim Charles Kooperberg Ruth J. F. Loos Karine A Viaud-Martinez Rasika A. Mathias Stephen T. McGarvey Braxton D. Mitchell Deborah Nickerson Kari E. North Bruce M. Psaty Susan Redline Alexander P. Reiner Ramachandran S. Vasan Stephen S. Rich Cristen Willer Jerome I. Rotter Daniel J. Rader Xihong Lin NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium Gina M. Peloso Pradeep Natarajan |
| author_sort | Margaret Sunitha Selvaraj |
| collection | DOAJ |
| description | Although the common genetic variants contributing to blood lipid levels have been studied, the contribution of rare variants is less understood. Here, the authors perform a rare coding and noncoding variant association study of blood lipid levels using whole genome sequencing data. |
| first_indexed | 2024-04-12T12:49:37Z |
| format | Article |
| id | doaj.art-6a6fd2ae2e2e4c998f1a649ed991ac74 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T12:49:37Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6a6fd2ae2e2e4c998f1a649ed991ac742022-12-22T03:32:31ZengNature PortfolioNature Communications2041-17232022-10-0113111810.1038/s41467-022-33510-7Whole genome sequence analysis of blood lipid levels in >66,000 individualsMargaret Sunitha Selvaraj0Xihao Li1Zilin Li2Akhil Pampana3David Y. Zhang4Joseph Park5Stella Aslibekyan6Joshua C. Bis7Jennifer A. Brody8Brian E. Cade9Lee-Ming Chuang10Ren-Hua Chung11Joanne E. Curran12Lisa de las Fuentes13Paul S. de Vries14Ravindranath Duggirala15Barry I. Freedman16Mariaelisa Graff17Xiuqing Guo18Nancy Heard-Costa19Bertha Hidalgo20Chii-Min Hwu21Marguerite R. Irvin22Tanika N. Kelly23Brian G. Kral24Leslie Lange25Xiaohui Li26Martin Lisa27Steven A. Lubitz28Ani W. Manichaikul29Preuss Michael30May E. Montasser31Alanna C. Morrison32Take Naseri33Jeffrey R. O’Connell34Nicholette D. Palmer35Patricia A. Peyser36Muagututia S. Reupena37Jennifer A. Smith38Xiao Sun39Kent D. Taylor40Russell P. Tracy41Michael Y. Tsai42Zhe Wang43Yuxuan Wang44Wei Bao45John T. Wilkins46Lisa R. Yanek47Wei Zhao48Donna K. Arnett49John Blangero50Eric Boerwinkle51Donald W. Bowden52Yii-Der Ida Chen53Adolfo Correa54L. Adrienne Cupples55Susan K. Dutcher56Patrick T. Ellinor57Myriam Fornage58Stacey Gabriel59Soren Germer60Richard Gibbs61Jiang He62Robert C. Kaplan63Sharon L. R. Kardia64Ryan Kim65Charles Kooperberg66Ruth J. F. Loos67Karine A Viaud-Martinez68Rasika A. Mathias69Stephen T. McGarvey70Braxton D. Mitchell71Deborah Nickerson72Kari E. North73Bruce M. Psaty74Susan Redline75Alexander P. Reiner76Ramachandran S. Vasan77Stephen S. Rich78Cristen Willer79Jerome I. Rotter80Daniel J. Rader81Xihong Lin82NHLBI Trans-Omics for Precision Medicine (TOPMed) ConsortiumGina M. Peloso83Pradeep Natarajan84Cardiovascular Research Center, Massachusetts General HospitalDepartment of Biostatistics, Harvard T.H. Chan School of Public HealthDepartment of Biostatistics, Harvard T.H. Chan School of Public HealthProgram in Medical and Population Genetics, Broad Institute of Harvard and MITDepartment of Genetics, Perelman School of Medicine, University of PennsylvaniaDepartment of Genetics, Perelman School of Medicine, University of PennsylvaniaDepartment of Epidemiology, University of Alabama at Birmingham School of Public HealthCardiovascular Health Research Unit, Department of Medicine, University of WashingtonCardiovascular Health Research Unit, Department of Medicine, University of WashingtonDepartment of Medicine, Brigham and Women’s Hospital, Harvard Medical SchoolDepartment of Internal Medicine, National Taiwan University HospitalInstitute of Population Health Sciences, National Health Research InstitutesDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of MedicineDepartment of Medicine, Cardiovascular Division, Washington University School of MedicineHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at HoustonDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of MedicineDepartment of Internal Medicine, Section on Nephrology, Wake Forest School of MedicineDepartment of Epidemiology, UNC Chapel HillThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical CenterDepartment of Neurology, Boston university School of MedicineDepartment of Epidemiology, University of Alabama at Birmingham School of Public HealthSection of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General HospitalDepartment of Epidemiology, University of Alabama at Birmingham School of Public HealthDepartment of Epidemiology, Tulane University School of Public Health and Tropical MedicineDepartment of Medicine, Johns Hopkins University School of MedicineDivision of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical CampusThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical CenterDepartment of Medicine, George Washington UniversityCardiovascular Research Center, Massachusetts General HospitalDepartment of Public Health Sciences, Center for Public Health Genomics, University of VirginiaThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount SinaiDepartment of Medicine, University of Maryland School of MedicineHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at HoustonMinistry of Health, Government of SamoaDepartment of Medicine, University of Maryland School of MedicineDepartment of Biochemistry, Wake Forest School of MedicineDepartment of Epidemiology, University of MichiganLutia i Puava ae Mapu i FagaleleDepartment of Epidemiology, University of MichiganDepartment of Epidemiology, Tulane University School of Public Health and Tropical MedicineThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical CenterDepartments of Pathology & Laboratory Medicine and Biochemistry, Larner College of Medicine at the University of VermontDepartment of Laboratory Medicine and Pathology, University of MinneostaThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount SinaiDepartment of Biostatistics, Boston University School of Public HealthInstitute of Public Health, Division of Life Sciences and Medicine, University of Science and Technology of ChinaDepartment of Medicine (Cardiology) and Department of Preventive Medicine, Northwestern University Feinberg School of MedicineDepartment of Medicine, Johns Hopkins University School of MedicineDepartment of Epidemiology, University of MichiganDean’s Office, University of Kentucky College of Public HealthDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of MedicineHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at HoustonDepartment of Biochemistry, Wake Forest School of MedicineLundquist Institute for Biomedical Innovation at Harbor-UCLA Medical CenterDepartment of Population Health Science, University of Mississippi Medical CenterDepartment of Biostatistics, Boston University School of Public HealthThe McDonnell Genome Institute, Washington University School of MedicineCardiovascular Research Center, Massachusetts General HospitalBrown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at HoustonBroad InstituteNew York Genome CenterBaylor College of Medicine Human Genome Sequencing CenterDepartment of Epidemiology, Tulane University School of Public Health and Tropical MedicineDepartment of Epidemiology and Population Health, Albert Einstein College of MedicineDepartment of Epidemiology, University of MichiganPsomagen, Inc. (formerly Macrogen USA)Division of Public Health Sciences, Fred Hutchinson Cancer Research CenterThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount SinaiIllumina Laboratory Services, Illumina. IncDepartment of Medicine, Johns Hopkins University School of MedicineDepartment of Epidemiology, International Health Institute, Brown UniversityDepartment of Medicine, University of Maryland School of MedicineUniversity of Washington, Department of Genome SciencesDepartment of Epidemiology, UNC Chapel HillCardiovascular Health Research Unit, Department of Medicine, University of WashingtonDepartment of Medicine, Brigham and Women’s Hospital, Harvard Medical SchoolDivision of Public Health Sciences, Fred Hutchinson Cancer Research CenterSections of Preventive medicine and Epidemiology, Cardiovascular medicine, Department of Medicine, Boston University School of MedicineDepartment of Public Health Sciences, Center for Public Health Genomics, University of VirginiaUniversity of Michigan, Internal MedicineThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical CenterDepartment of Genetics, Perelman School of Medicine, University of PennsylvaniaProgram in Medical and Population Genetics, Broad Institute of Harvard and MITDepartment of Biostatistics, Boston University School of Public HealthCardiovascular Research Center, Massachusetts General HospitalAlthough the common genetic variants contributing to blood lipid levels have been studied, the contribution of rare variants is less understood. Here, the authors perform a rare coding and noncoding variant association study of blood lipid levels using whole genome sequencing data.https://doi.org/10.1038/s41467-022-33510-7 |
| spellingShingle | Margaret Sunitha Selvaraj Xihao Li Zilin Li Akhil Pampana David Y. Zhang Joseph Park Stella Aslibekyan Joshua C. Bis Jennifer A. Brody Brian E. Cade Lee-Ming Chuang Ren-Hua Chung Joanne E. Curran Lisa de las Fuentes Paul S. de Vries Ravindranath Duggirala Barry I. Freedman Mariaelisa Graff Xiuqing Guo Nancy Heard-Costa Bertha Hidalgo Chii-Min Hwu Marguerite R. Irvin Tanika N. Kelly Brian G. Kral Leslie Lange Xiaohui Li Martin Lisa Steven A. Lubitz Ani W. Manichaikul Preuss Michael May E. Montasser Alanna C. Morrison Take Naseri Jeffrey R. O’Connell Nicholette D. Palmer Patricia A. Peyser Muagututia S. Reupena Jennifer A. Smith Xiao Sun Kent D. Taylor Russell P. Tracy Michael Y. Tsai Zhe Wang Yuxuan Wang Wei Bao John T. Wilkins Lisa R. Yanek Wei Zhao Donna K. Arnett John Blangero Eric Boerwinkle Donald W. Bowden Yii-Der Ida Chen Adolfo Correa L. Adrienne Cupples Susan K. Dutcher Patrick T. Ellinor Myriam Fornage Stacey Gabriel Soren Germer Richard Gibbs Jiang He Robert C. Kaplan Sharon L. R. Kardia Ryan Kim Charles Kooperberg Ruth J. F. Loos Karine A Viaud-Martinez Rasika A. Mathias Stephen T. McGarvey Braxton D. Mitchell Deborah Nickerson Kari E. North Bruce M. Psaty Susan Redline Alexander P. Reiner Ramachandran S. Vasan Stephen S. Rich Cristen Willer Jerome I. Rotter Daniel J. Rader Xihong Lin NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium Gina M. Peloso Pradeep Natarajan Whole genome sequence analysis of blood lipid levels in >66,000 individuals Nature Communications |
| title | Whole genome sequence analysis of blood lipid levels in >66,000 individuals |
| title_full | Whole genome sequence analysis of blood lipid levels in >66,000 individuals |
| title_fullStr | Whole genome sequence analysis of blood lipid levels in >66,000 individuals |
| title_full_unstemmed | Whole genome sequence analysis of blood lipid levels in >66,000 individuals |
| title_short | Whole genome sequence analysis of blood lipid levels in >66,000 individuals |
| title_sort | whole genome sequence analysis of blood lipid levels in 66 000 individuals |
| url | https://doi.org/10.1038/s41467-022-33510-7 |
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