Mesenchymal Stromal Cells in Osteoarthritis: Evidence for Structural Benefit and Cartilage Repair
Osteoarthritis (OA) presents a major clinical challenge to rheumatologists and orthopedists due to the lack of available drugs reducing structural degradation. Mesenchymal stromal cells (MSCs) may represent new therapeutic approaches in cartilage regeneration. In this review, we highlight the latest...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/10/6/1278 |
| _version_ | 1797489731124068352 |
|---|---|
| author | Yujie Song Christian Jorgensen |
| author_facet | Yujie Song Christian Jorgensen |
| author_sort | Yujie Song |
| collection | DOAJ |
| description | Osteoarthritis (OA) presents a major clinical challenge to rheumatologists and orthopedists due to the lack of available drugs reducing structural degradation. Mesenchymal stromal cells (MSCs) may represent new therapeutic approaches in cartilage regeneration. In this review, we highlight the latest knowledge on the biological properties of MSC, such as their chondrogenic and immunomodulatory potential, and we give a brief overview of the effects of MSCs in preclinical and clinical studies of OA treatment and also compare different MSC sources, with the adipose tissue-derived MSCs being promising. Then, we focus on their structural benefit in treating OA and summarize the current evidence for the assessment of cartilage in OA according to magnetic resonance imaging (MRI) and second-look arthroscopy after MSC therapy. Finally, this review provides a brief perspective on enhancing the activity of MSCs. |
| first_indexed | 2024-03-10T00:21:48Z |
| format | Article |
| id | doaj.art-6a6fe26587034c83bf6fef57fb259ee4 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T00:21:48Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-6a6fe26587034c83bf6fef57fb259ee42023-11-23T15:41:59ZengMDPI AGBiomedicines2227-90592022-05-01106127810.3390/biomedicines10061278Mesenchymal Stromal Cells in Osteoarthritis: Evidence for Structural Benefit and Cartilage RepairYujie Song0Christian Jorgensen1IRMB, CARTIGEN, University of Montpellier, Inserm, CHU de Montpellier, 34090 Montpellier, FranceIRMB, CARTIGEN, University of Montpellier, Inserm, CHU de Montpellier, 34090 Montpellier, FranceOsteoarthritis (OA) presents a major clinical challenge to rheumatologists and orthopedists due to the lack of available drugs reducing structural degradation. Mesenchymal stromal cells (MSCs) may represent new therapeutic approaches in cartilage regeneration. In this review, we highlight the latest knowledge on the biological properties of MSC, such as their chondrogenic and immunomodulatory potential, and we give a brief overview of the effects of MSCs in preclinical and clinical studies of OA treatment and also compare different MSC sources, with the adipose tissue-derived MSCs being promising. Then, we focus on their structural benefit in treating OA and summarize the current evidence for the assessment of cartilage in OA according to magnetic resonance imaging (MRI) and second-look arthroscopy after MSC therapy. Finally, this review provides a brief perspective on enhancing the activity of MSCs.https://www.mdpi.com/2227-9059/10/6/1278cell therapymesenchymal stromal cellsadipose tissuebone marrowosteoarthritisMRI |
| spellingShingle | Yujie Song Christian Jorgensen Mesenchymal Stromal Cells in Osteoarthritis: Evidence for Structural Benefit and Cartilage Repair Biomedicines cell therapy mesenchymal stromal cells adipose tissue bone marrow osteoarthritis MRI |
| title | Mesenchymal Stromal Cells in Osteoarthritis: Evidence for Structural Benefit and Cartilage Repair |
| title_full | Mesenchymal Stromal Cells in Osteoarthritis: Evidence for Structural Benefit and Cartilage Repair |
| title_fullStr | Mesenchymal Stromal Cells in Osteoarthritis: Evidence for Structural Benefit and Cartilage Repair |
| title_full_unstemmed | Mesenchymal Stromal Cells in Osteoarthritis: Evidence for Structural Benefit and Cartilage Repair |
| title_short | Mesenchymal Stromal Cells in Osteoarthritis: Evidence for Structural Benefit and Cartilage Repair |
| title_sort | mesenchymal stromal cells in osteoarthritis evidence for structural benefit and cartilage repair |
| topic | cell therapy mesenchymal stromal cells adipose tissue bone marrow osteoarthritis MRI |
| url | https://www.mdpi.com/2227-9059/10/6/1278 |
| work_keys_str_mv | AT yujiesong mesenchymalstromalcellsinosteoarthritisevidenceforstructuralbenefitandcartilagerepair AT christianjorgensen mesenchymalstromalcellsinosteoarthritisevidenceforstructuralbenefitandcartilagerepair |