The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis
Poupak Rahimzadeh,1 Farnad Imani,1 Seyed Hamid Reza Faiz,2 Saeed Reza Entezary,3 Mahnaz Narimani Zamanabadi,4 Mahmoud Reza Alebouyeh3 1Pain Research Center, Iran University of Medical Sciences, Tehran, Iran; 2Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran; 3Anesthe...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2018-01-01
|
| Series: | Clinical Interventions in Aging |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-effects-of-injecting-intra-articular-platelet-rich-plasma-or-prolo-peer-reviewed-article-CIA |
| _version_ | 1818346839364075520 |
|---|---|
| author | Rahimzadeh P Imani F Faiz SHR Entezary SR Zamanabadi MN Alebouyeh MR |
| author_facet | Rahimzadeh P Imani F Faiz SHR Entezary SR Zamanabadi MN Alebouyeh MR |
| author_sort | Rahimzadeh P |
| collection | DOAJ |
| description | Poupak Rahimzadeh,1 Farnad Imani,1 Seyed Hamid Reza Faiz,2 Saeed Reza Entezary,3 Mahnaz Narimani Zamanabadi,4 Mahmoud Reza Alebouyeh3 1Pain Research Center, Iran University of Medical Sciences, Tehran, Iran; 2Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran; 3Anesthesia Department, Iran University of Medical Sciences, Tehran, Iran; 4Pain Fellowship, Iran University of Medical Sciences, Tehran, Iran Introduction: Osteoarthritis (OA) is a chronic joint disease that usually occurs in older people and leads to pain and disabilities. OA treatment ranges from drug therapy to surgery. Drug and rehabilitation therapy are preferred over surgery, and, especially, there is a tendency toward compounds causing regenerative changes in the knee joint. In the present study, the effects of platelet-rich plasma (PRP) injection and prolotherapy (PRL) were examined on the level of pain and function of the knee joint in patients with OA.Methodology: After fulfilling the inclusion criteria and signing the informed consent form, 42 patients with knee OA were scheduled for intra-articular injection in the present randomized, double-blind, clinical trial. Following admission to the operating pain room, the condition of the patient’s knee was evaluated first via the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and, then, ultrasound-guided knee injection was done. Accordingly, patients in the PRP therapy group received 7 mL PRP solution and those in the PRL group received 7 mL 25% dextrose. Using the WOMAC, levels of pain and knee function were evaluated and recorded for each patient immediately prior to the first injection as well as at 1 month (immediately prior to the second injection), 2 months (a month after the second injection), and 6 months later. Data collected were analyzed using the SPSS v.20.Results: During the first and second months, a rapid decrease in the overall WOMAC score was observed in both groups. The overall WOMAC score increased at the sixth month, but was lower than the overall WOMAC score in the first month. Statistical analysis indicated that the overall WOMAC score significantly decreased in both groups of patients over 6 months.Conclusion: Results of the present study suggested a significant decrease in the overall WOMAC score of patients who undergo either PRP therapy or PRL. This positive change in the overall WOMAC score led to an improvement in the quality of life of patients with knee OA shortly after the first injection. PRP injection is more effective than PRL in the treatment of knee OA. Keywords: knee osteoarthritis, platelet-rich plasma, prolotherapy, ultrasound |
| first_indexed | 2024-12-13T17:24:38Z |
| format | Article |
| id | doaj.art-6a70c7e2227b4c928b5eccbe4d7cac75 |
| institution | Directory Open Access Journal |
| issn | 1178-1998 |
| language | English |
| last_indexed | 2024-12-13T17:24:38Z |
| publishDate | 2018-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Interventions in Aging |
| spelling | doaj.art-6a70c7e2227b4c928b5eccbe4d7cac752022-12-21T23:37:13ZengDove Medical PressClinical Interventions in Aging1178-19982018-01-01Volume 13737936242The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritisRahimzadeh PImani FFaiz SHREntezary SRZamanabadi MNAlebouyeh MRPoupak Rahimzadeh,1 Farnad Imani,1 Seyed Hamid Reza Faiz,2 Saeed Reza Entezary,3 Mahnaz Narimani Zamanabadi,4 Mahmoud Reza Alebouyeh3 1Pain Research Center, Iran University of Medical Sciences, Tehran, Iran; 2Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran; 3Anesthesia Department, Iran University of Medical Sciences, Tehran, Iran; 4Pain Fellowship, Iran University of Medical Sciences, Tehran, Iran Introduction: Osteoarthritis (OA) is a chronic joint disease that usually occurs in older people and leads to pain and disabilities. OA treatment ranges from drug therapy to surgery. Drug and rehabilitation therapy are preferred over surgery, and, especially, there is a tendency toward compounds causing regenerative changes in the knee joint. In the present study, the effects of platelet-rich plasma (PRP) injection and prolotherapy (PRL) were examined on the level of pain and function of the knee joint in patients with OA.Methodology: After fulfilling the inclusion criteria and signing the informed consent form, 42 patients with knee OA were scheduled for intra-articular injection in the present randomized, double-blind, clinical trial. Following admission to the operating pain room, the condition of the patient’s knee was evaluated first via the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and, then, ultrasound-guided knee injection was done. Accordingly, patients in the PRP therapy group received 7 mL PRP solution and those in the PRL group received 7 mL 25% dextrose. Using the WOMAC, levels of pain and knee function were evaluated and recorded for each patient immediately prior to the first injection as well as at 1 month (immediately prior to the second injection), 2 months (a month after the second injection), and 6 months later. Data collected were analyzed using the SPSS v.20.Results: During the first and second months, a rapid decrease in the overall WOMAC score was observed in both groups. The overall WOMAC score increased at the sixth month, but was lower than the overall WOMAC score in the first month. Statistical analysis indicated that the overall WOMAC score significantly decreased in both groups of patients over 6 months.Conclusion: Results of the present study suggested a significant decrease in the overall WOMAC score of patients who undergo either PRP therapy or PRL. This positive change in the overall WOMAC score led to an improvement in the quality of life of patients with knee OA shortly after the first injection. PRP injection is more effective than PRL in the treatment of knee OA. Keywords: knee osteoarthritis, platelet-rich plasma, prolotherapy, ultrasoundhttps://www.dovepress.com/the-effects-of-injecting-intra-articular-platelet-rich-plasma-or-prolo-peer-reviewed-article-CIAKnee OsteoarthritisPlatelet-Rich PlasmaProlotherapyUltrasound |
| spellingShingle | Rahimzadeh P Imani F Faiz SHR Entezary SR Zamanabadi MN Alebouyeh MR The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis Clinical Interventions in Aging Knee Osteoarthritis Platelet-Rich Plasma Prolotherapy Ultrasound |
| title | The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis |
| title_full | The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis |
| title_fullStr | The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis |
| title_full_unstemmed | The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis |
| title_short | The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis |
| title_sort | effects of injecting intra articular platelet rich plasma or prolotherapy on pain score and function in knee osteoarthritis |
| topic | Knee Osteoarthritis Platelet-Rich Plasma Prolotherapy Ultrasound |
| url | https://www.dovepress.com/the-effects-of-injecting-intra-articular-platelet-rich-plasma-or-prolo-peer-reviewed-article-CIA |
| work_keys_str_mv | AT rahimzadehp theeffectsofinjectingintraarticularplateletrichplasmaorprolotherapyonpainscoreandfunctioninkneeosteoarthritis AT imanif theeffectsofinjectingintraarticularplateletrichplasmaorprolotherapyonpainscoreandfunctioninkneeosteoarthritis AT faizshr theeffectsofinjectingintraarticularplateletrichplasmaorprolotherapyonpainscoreandfunctioninkneeosteoarthritis AT entezarysr theeffectsofinjectingintraarticularplateletrichplasmaorprolotherapyonpainscoreandfunctioninkneeosteoarthritis AT zamanabadimn theeffectsofinjectingintraarticularplateletrichplasmaorprolotherapyonpainscoreandfunctioninkneeosteoarthritis AT alebouyehmr theeffectsofinjectingintraarticularplateletrichplasmaorprolotherapyonpainscoreandfunctioninkneeosteoarthritis AT rahimzadehp effectsofinjectingintraarticularplateletrichplasmaorprolotherapyonpainscoreandfunctioninkneeosteoarthritis AT imanif effectsofinjectingintraarticularplateletrichplasmaorprolotherapyonpainscoreandfunctioninkneeosteoarthritis AT faizshr effectsofinjectingintraarticularplateletrichplasmaorprolotherapyonpainscoreandfunctioninkneeosteoarthritis AT entezarysr effectsofinjectingintraarticularplateletrichplasmaorprolotherapyonpainscoreandfunctioninkneeosteoarthritis AT zamanabadimn effectsofinjectingintraarticularplateletrichplasmaorprolotherapyonpainscoreandfunctioninkneeosteoarthritis AT alebouyehmr effectsofinjectingintraarticularplateletrichplasmaorprolotherapyonpainscoreandfunctioninkneeosteoarthritis |