Study of genetic markers of cardiac arrhythmias in Kazakhstan
Introduction: Cardiac arrhythmias are the most common cause of mortality and sudden cardiac death worldwide. In the past decade, genetic factors underlying arrhythmogenic diseases have been revealed and given novel insights in to the understanding and treatment of arrhythmias predisposing one to sud...
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| Format: | Article |
| Language: | English |
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University Library System, University of Pittsburgh
2014-01-01
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| Series: | Central Asian Journal of Global Health |
| Online Access: | http://cajgh.pitt.edu/ojs/index.php/cajgh/article/view/85 |
| _version_ | 1818920430524694528 |
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| author | Makhabbat Bekbossynova Ainur Akilzhanova Zhannur Abilova Ayan Abdrahmanov Omirbek Nuralinov |
| author_facet | Makhabbat Bekbossynova Ainur Akilzhanova Zhannur Abilova Ayan Abdrahmanov Omirbek Nuralinov |
| author_sort | Makhabbat Bekbossynova |
| collection | DOAJ |
| description | Introduction: Cardiac arrhythmias are the most common cause of mortality and sudden cardiac death worldwide. In the past decade, genetic factors underlying arrhythmogenic diseases have been revealed and given novel insights in to the understanding and treatment of arrhythmias predisposing one to sudden cardiac death.
Material and methods: We conducted a pilot genetic screening of two patients with catecholaminergic polymorphic ventricular tachycardia (CPVT) and 14 patients with ventricular tachycardia (VT) for genetic variants in the human ryanodine receptor gene 2 (hRYR2). The most relevant 45 hot-spot exons of hRYR2 were amplified by polymerase chain reaction (PCR) and directly sequenced.
Results: One novel mutation in a CPVT patient (c.A13892T; p.D4631V) and a novel mutation in a VT patient (c.G5428C; p.V1810L) were identified. Both variants are located at phylogenetically conserved positions and predicted pathogenesis. Three known synonymous SNPs (rs3765097, rs2253273, and TMP ESp1 237664067) were detected in the study group. No further variants within the target regions were detected in the study group.
Conclusion: The results of study can be applied to risk asssessment for life-threatening arrhythmias and assist in development of appropriate strategies for prevention of sudden cardiac death. The implementation of these strategies would assist in the management of patients with genetically determined arrhythmias in Kazakhstan. |
| first_indexed | 2024-12-20T01:21:38Z |
| format | Article |
| id | doaj.art-6a71de3b40e7426d847a2809e0e8d7c3 |
| institution | Directory Open Access Journal |
| issn | 2166-7403 |
| language | English |
| last_indexed | 2024-12-20T01:21:38Z |
| publishDate | 2014-01-01 |
| publisher | University Library System, University of Pittsburgh |
| record_format | Article |
| series | Central Asian Journal of Global Health |
| spelling | doaj.art-6a71de3b40e7426d847a2809e0e8d7c32022-12-21T19:58:25ZengUniversity Library System, University of PittsburghCentral Asian Journal of Global Health2166-74032014-01-012010.5195/cajgh.2013.8532Study of genetic markers of cardiac arrhythmias in KazakhstanMakhabbat Bekbossynova0Ainur Akilzhanova1Zhannur Abilova2Ayan Abdrahmanov3Omirbek Nuralinov4National Research Center for Cardiac Surgery, AstanaDepartment for Organization and Development of Genomic and Personalized Medicine, Center for Life Sciences, Nazarbayev University, AstanaDepartment for Organization and Development of Genomic and Personalized Medicine, Center for Life Sciences, Nazarbayev University, AstanaNational Research Center for Cardiac Surgery, AstanaNational Research Center for Cardiac Surgery, AstanaIntroduction: Cardiac arrhythmias are the most common cause of mortality and sudden cardiac death worldwide. In the past decade, genetic factors underlying arrhythmogenic diseases have been revealed and given novel insights in to the understanding and treatment of arrhythmias predisposing one to sudden cardiac death. Material and methods: We conducted a pilot genetic screening of two patients with catecholaminergic polymorphic ventricular tachycardia (CPVT) and 14 patients with ventricular tachycardia (VT) for genetic variants in the human ryanodine receptor gene 2 (hRYR2). The most relevant 45 hot-spot exons of hRYR2 were amplified by polymerase chain reaction (PCR) and directly sequenced. Results: One novel mutation in a CPVT patient (c.A13892T; p.D4631V) and a novel mutation in a VT patient (c.G5428C; p.V1810L) were identified. Both variants are located at phylogenetically conserved positions and predicted pathogenesis. Three known synonymous SNPs (rs3765097, rs2253273, and TMP ESp1 237664067) were detected in the study group. No further variants within the target regions were detected in the study group. Conclusion: The results of study can be applied to risk asssessment for life-threatening arrhythmias and assist in development of appropriate strategies for prevention of sudden cardiac death. The implementation of these strategies would assist in the management of patients with genetically determined arrhythmias in Kazakhstan.http://cajgh.pitt.edu/ojs/index.php/cajgh/article/view/85 |
| spellingShingle | Makhabbat Bekbossynova Ainur Akilzhanova Zhannur Abilova Ayan Abdrahmanov Omirbek Nuralinov Study of genetic markers of cardiac arrhythmias in Kazakhstan Central Asian Journal of Global Health |
| title | Study of genetic markers of cardiac arrhythmias in Kazakhstan |
| title_full | Study of genetic markers of cardiac arrhythmias in Kazakhstan |
| title_fullStr | Study of genetic markers of cardiac arrhythmias in Kazakhstan |
| title_full_unstemmed | Study of genetic markers of cardiac arrhythmias in Kazakhstan |
| title_short | Study of genetic markers of cardiac arrhythmias in Kazakhstan |
| title_sort | study of genetic markers of cardiac arrhythmias in kazakhstan |
| url | http://cajgh.pitt.edu/ojs/index.php/cajgh/article/view/85 |
| work_keys_str_mv | AT makhabbatbekbossynova studyofgeneticmarkersofcardiacarrhythmiasinkazakhstan AT ainurakilzhanova studyofgeneticmarkersofcardiacarrhythmiasinkazakhstan AT zhannurabilova studyofgeneticmarkersofcardiacarrhythmiasinkazakhstan AT ayanabdrahmanov studyofgeneticmarkersofcardiacarrhythmiasinkazakhstan AT omirbeknuralinov studyofgeneticmarkersofcardiacarrhythmiasinkazakhstan |