Correlation of Vitamin D with metabolic parameters in polycystic ovarian syndrome
Background: Polycystic ovarian syndrome (PCOS) and hypovitaminosis D are the two most common endocrine disorders in young women leading to many adverse metabolic consequences. We evaluated the correlation of 25-hydroxy Vitamin D (25OHD) with metabolic parameters and insulin resistance in PCOS. Mater...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Journal of Family Medicine and Primary Care |
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| Online Access: | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2017;volume=6;issue=1;spage=115;epage=119;aulast=Kumar |
| _version_ | 1819106913631076352 |
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| author | Arun Kumar Satish Barki Vinod Raghav Ashutosh Chaturvedi K. V. S. Hari Kumar |
| author_facet | Arun Kumar Satish Barki Vinod Raghav Ashutosh Chaturvedi K. V. S. Hari Kumar |
| author_sort | Arun Kumar |
| collection | DOAJ |
| description | Background: Polycystic ovarian syndrome (PCOS) and hypovitaminosis D are the two most common endocrine disorders in young women leading to many adverse metabolic consequences. We evaluated the correlation of 25-hydroxy Vitamin D (25OHD) with metabolic parameters and insulin resistance in PCOS. Materials and Methods: We included 100 PCOS patients (age 18–40 years, duration> 6 months) serially, in this cross-sectional study. We excluded patients with past use of insulin sensitizers and hormone therapy. All patients underwent a physical examination, body fat estimation, and a single fasting blood sample was analyzed for the biochemical parameters. The patients were divided into 2 groups as per the 25OHD level: Group 1 (Deficient, <30 ng/mL) and Group 2 (normal). The data were analyzed using appropriate statistical methods, and aP< 0.05 was considered statistically significant. Results: The study population had a mean age of 28.6 ± 6.3 years, body mass index (BMI) 30.4 ± 6.1 kg/m2 and body fat of 39.1 ± 13%. A total of 90 women had 25OHD deficiency, and hypovitaminosis D was observed more in younger, obese patients. Patients with hypovitaminosis D had a higher BMI (P = 0.0124), low- high-density lipoprotein (P = 0.0094), calcium (P ≤ 0.0001), and elevated testosterone (P = 0.0412) in comparison with normal 25OHD patients. None of the metabolic parameters showed significant correlation with 25OHD (P > 0.05). Conclusion: Hypovitaminosis D is very common in PCOS patients and exacerbates the metabolic abnormalities. It is essential to screen all the PCOS patients for 25OHD deficiency, and further large-scale studies are required to confirm our findings. |
| first_indexed | 2024-12-22T02:45:42Z |
| format | Article |
| id | doaj.art-6a731e15d24347e0b59d002b365f3651 |
| institution | Directory Open Access Journal |
| issn | 2249-4863 |
| language | English |
| last_indexed | 2024-12-22T02:45:42Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj.art-6a731e15d24347e0b59d002b365f36512022-12-21T18:41:31ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632017-01-016111511910.4103/2249-4863.214985Correlation of Vitamin D with metabolic parameters in polycystic ovarian syndromeArun KumarSatish BarkiVinod RaghavAshutosh ChaturvediK. V. S. Hari KumarBackground: Polycystic ovarian syndrome (PCOS) and hypovitaminosis D are the two most common endocrine disorders in young women leading to many adverse metabolic consequences. We evaluated the correlation of 25-hydroxy Vitamin D (25OHD) with metabolic parameters and insulin resistance in PCOS. Materials and Methods: We included 100 PCOS patients (age 18–40 years, duration> 6 months) serially, in this cross-sectional study. We excluded patients with past use of insulin sensitizers and hormone therapy. All patients underwent a physical examination, body fat estimation, and a single fasting blood sample was analyzed for the biochemical parameters. The patients were divided into 2 groups as per the 25OHD level: Group 1 (Deficient, <30 ng/mL) and Group 2 (normal). The data were analyzed using appropriate statistical methods, and aP< 0.05 was considered statistically significant. Results: The study population had a mean age of 28.6 ± 6.3 years, body mass index (BMI) 30.4 ± 6.1 kg/m2 and body fat of 39.1 ± 13%. A total of 90 women had 25OHD deficiency, and hypovitaminosis D was observed more in younger, obese patients. Patients with hypovitaminosis D had a higher BMI (P = 0.0124), low- high-density lipoprotein (P = 0.0094), calcium (P ≤ 0.0001), and elevated testosterone (P = 0.0412) in comparison with normal 25OHD patients. None of the metabolic parameters showed significant correlation with 25OHD (P > 0.05). Conclusion: Hypovitaminosis D is very common in PCOS patients and exacerbates the metabolic abnormalities. It is essential to screen all the PCOS patients for 25OHD deficiency, and further large-scale studies are required to confirm our findings.http://www.jfmpc.com/article.asp?issn=2249-4863;year=2017;volume=6;issue=1;spage=115;epage=119;aulast=KumarIndiainsulin resistanceobesitypolycystic ovarian syndromeVitamin D |
| spellingShingle | Arun Kumar Satish Barki Vinod Raghav Ashutosh Chaturvedi K. V. S. Hari Kumar Correlation of Vitamin D with metabolic parameters in polycystic ovarian syndrome Journal of Family Medicine and Primary Care India insulin resistance obesity polycystic ovarian syndrome Vitamin D |
| title | Correlation of Vitamin D with metabolic parameters in polycystic ovarian syndrome |
| title_full | Correlation of Vitamin D with metabolic parameters in polycystic ovarian syndrome |
| title_fullStr | Correlation of Vitamin D with metabolic parameters in polycystic ovarian syndrome |
| title_full_unstemmed | Correlation of Vitamin D with metabolic parameters in polycystic ovarian syndrome |
| title_short | Correlation of Vitamin D with metabolic parameters in polycystic ovarian syndrome |
| title_sort | correlation of vitamin d with metabolic parameters in polycystic ovarian syndrome |
| topic | India insulin resistance obesity polycystic ovarian syndrome Vitamin D |
| url | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2017;volume=6;issue=1;spage=115;epage=119;aulast=Kumar |
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