Epithelial Cell Abnormality in Cervical Pap Smear with Histopathological Correlation among Patients of a Tertiary Care Centre in Eastern Nepal
Background: Cervical cancer is a leading health problem among women all over the world with significant mortality and morbidity in developing countries like Nepal. Pap smear is an effective and cost efficient diagnostic technique for cervical lesions. This study aims at histopathological correlation...
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| Format: | Article |
| Language: | English |
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Nobel Medical College Teaching Hospital
2022-06-01
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| Series: | Journal of Nobel Medical College |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/JoNMC/article/view/46066 |
| _version_ | 1818488614528483328 |
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| author | Manish Kumar Das Rashmita Bhandari |
| author_facet | Manish Kumar Das Rashmita Bhandari |
| author_sort | Manish Kumar Das |
| collection | DOAJ |
| description | Background: Cervical cancer is a leading health problem among women all over the world with significant mortality and morbidity in developing countries like Nepal. Pap smear is an effective and cost efficient diagnostic technique for cervical lesions. This study aims at histopathological correlation of cervical Pap smears.
Materials and Methods: A cross sectional study was conducted from January 2020 to January 2022 in Pathology department of Nobel Medical College Teaching Hospital (NMCTH). 119 cases of cervical Pap smear were reported using the Bethesda system and correlated with histopathological examination findings for various epithelial cell abnormalities. Analysis was done using SPSS software version 20.
Results: Out of 5110 smears examined, 119 were positive for epithelial cell abnormalities. Cellular abnormality was commonly seen between 31-60 years of age. Low grade Squamous Intraepithelial Lesion was the commonest lesion found. Pap smear findings had good concordance rates with histopathological findings for individual lesions. The overall sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of Pap smear were 84%, 23.1%, 89.9%, 15% and 77.3% respectively.
Conclusion: Pap smear has a good diagnostic accuracy, sensitivity and positive predictive value in diagnosing cervical lesions in comparison to histopathological examination |
| first_indexed | 2024-12-10T16:53:30Z |
| format | Article |
| id | doaj.art-6a75a808a51043ef8aadffaeb17ec6b2 |
| institution | Directory Open Access Journal |
| issn | 2091-2331 2091-234X |
| language | English |
| last_indexed | 2024-12-10T16:53:30Z |
| publishDate | 2022-06-01 |
| publisher | Nobel Medical College Teaching Hospital |
| record_format | Article |
| series | Journal of Nobel Medical College |
| spelling | doaj.art-6a75a808a51043ef8aadffaeb17ec6b22022-12-22T01:40:48ZengNobel Medical College Teaching HospitalJournal of Nobel Medical College2091-23312091-234X2022-06-01111677010.3126/jonmc.v11i1.4606673133Epithelial Cell Abnormality in Cervical Pap Smear with Histopathological Correlation among Patients of a Tertiary Care Centre in Eastern NepalManish Kumar Das0https://orcid.org/0000-0002-4209-4274Rashmita Bhandari1Department of Pathology, Nobel Medical College Teaching Hospital, Biratnagar, NepalDepartment of Pathology, Nobel Medical College Teaching Hospital, Biratnagar, NepalBackground: Cervical cancer is a leading health problem among women all over the world with significant mortality and morbidity in developing countries like Nepal. Pap smear is an effective and cost efficient diagnostic technique for cervical lesions. This study aims at histopathological correlation of cervical Pap smears. Materials and Methods: A cross sectional study was conducted from January 2020 to January 2022 in Pathology department of Nobel Medical College Teaching Hospital (NMCTH). 119 cases of cervical Pap smear were reported using the Bethesda system and correlated with histopathological examination findings for various epithelial cell abnormalities. Analysis was done using SPSS software version 20. Results: Out of 5110 smears examined, 119 were positive for epithelial cell abnormalities. Cellular abnormality was commonly seen between 31-60 years of age. Low grade Squamous Intraepithelial Lesion was the commonest lesion found. Pap smear findings had good concordance rates with histopathological findings for individual lesions. The overall sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of Pap smear were 84%, 23.1%, 89.9%, 15% and 77.3% respectively. Conclusion: Pap smear has a good diagnostic accuracy, sensitivity and positive predictive value in diagnosing cervical lesions in comparison to histopathological examinationhttps://www.nepjol.info/index.php/JoNMC/article/view/46066cervical cancercytologypap smear |
| spellingShingle | Manish Kumar Das Rashmita Bhandari Epithelial Cell Abnormality in Cervical Pap Smear with Histopathological Correlation among Patients of a Tertiary Care Centre in Eastern Nepal Journal of Nobel Medical College cervical cancer cytology pap smear |
| title | Epithelial Cell Abnormality in Cervical Pap Smear with Histopathological Correlation among Patients of a Tertiary Care Centre in Eastern Nepal |
| title_full | Epithelial Cell Abnormality in Cervical Pap Smear with Histopathological Correlation among Patients of a Tertiary Care Centre in Eastern Nepal |
| title_fullStr | Epithelial Cell Abnormality in Cervical Pap Smear with Histopathological Correlation among Patients of a Tertiary Care Centre in Eastern Nepal |
| title_full_unstemmed | Epithelial Cell Abnormality in Cervical Pap Smear with Histopathological Correlation among Patients of a Tertiary Care Centre in Eastern Nepal |
| title_short | Epithelial Cell Abnormality in Cervical Pap Smear with Histopathological Correlation among Patients of a Tertiary Care Centre in Eastern Nepal |
| title_sort | epithelial cell abnormality in cervical pap smear with histopathological correlation among patients of a tertiary care centre in eastern nepal |
| topic | cervical cancer cytology pap smear |
| url | https://www.nepjol.info/index.php/JoNMC/article/view/46066 |
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