The choice of the filtering method in microarrays affects the inference regarding dosage compensation of the active X-chromosome.

The choice of the filtering method in microarrays affects the inference regarding dosage compensation of the active X-chromosome.

<h4>Background</h4>The hypothesis of dosage compensation of genes of the X chromosome, supported by previous microarray studies, was recently challenged by RNA-sequencing data. It was suggested that microarray studies were biased toward an over-estimation of X-linked expression levels as...

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Bibliographic Details
Main Authors: Raphaële Castagné, Maxime Rotival, Tanja Zeller, Philipp S Wild, Vinh Truong, David-Alexandre Trégouët, Thomas Munzel, Andreas Ziegler, François Cambien, Stefan Blankenberg, Laurence Tiret
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21912656/?tool=EBI

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