Brain Imaging Changes and Related Risk Factors of Cognitive Impairment in Patients With Heart Failure
Background/AimsTo explore the imaging changes and related risk factors of heart failure (HF) patients with cognitive impairment (CI).MethodsA literature search was systematically carried out in PubMed, Web of Science, Embase, and Cochrane Library. In this systematic review, important relevant inform...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-01-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.838680/full |
| _version_ | 1798025011604226048 |
|---|---|
| author | Yangyang Jiang Lei Wang Ziwen Lu Shiqi Chen Yu Teng Tong Li Yang Li Yingzhen Xie Mingjing Zhao |
| author_facet | Yangyang Jiang Lei Wang Ziwen Lu Shiqi Chen Yu Teng Tong Li Yang Li Yingzhen Xie Mingjing Zhao |
| author_sort | Yangyang Jiang |
| collection | DOAJ |
| description | Background/AimsTo explore the imaging changes and related risk factors of heart failure (HF) patients with cognitive impairment (CI).MethodsA literature search was systematically carried out in PubMed, Web of Science, Embase, and Cochrane Library. In this systematic review, important relevant information was extracted according to the inclusion and exclusion criteria. The methodological quality was assessed by three scales according to the different study types.ResultsFinally, 66 studies were included, involving 33,579 patients. In the imaging changes, the severity of medial temporal lobe atrophy (MTA) and the decrease of gray Matter (GM) volume were closely related to the cognitive decline. The reduction of cerebral blood flow (CBF) may be correlated with CI. However, the change of white matter (WM) volume was possibly independent of CI in HF patients. Specific risk factors were analyzed, and the data indicated that the increased levels of B-type natriuretic peptide (BNP)/N-terminal pro-B-type natriuretic peptide (NT-proBNP), and the comorbidities of HF, including atrial fibrillation (AF), diabetes mellitus (DM) and anemia were definitely correlated with CI in patients with HF, respectively. Certain studies had also obtained independent correlation results. Body mass index (BMI), depression and sleep disorder exhibited a tendency to be associated with CI. Low ejection fraction (EF) value (<30%) was inclined to be associated with the decline in cognitive function. However, no significant differences were noted between heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF) in cognitive scores.ConclusionBNP/NT-proBNP and the comorbidities of HF including AF, DM and anemia were inextricably correlated with CI in patients with HF, respectively. These parameters were independent factors. The severity of MTA, GM volume, BMI index, depression, sleep disorder, and low EF value (<30%) have a disposition to associated with CI. The reduction in the CBF volume may be related to CI, whereas the WM volume may not be associated with CI in HF patients. The present systematic review provides an important basis for the prevention and treatment of CI following HF. |
| first_indexed | 2024-04-11T18:11:52Z |
| format | Article |
| id | doaj.art-6a783c50b0f6499591751e12d505eb22 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-11T18:11:52Z |
| publishDate | 2022-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-6a783c50b0f6499591751e12d505eb222022-12-22T04:10:06ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-01-01810.3389/fcvm.2021.838680838680Brain Imaging Changes and Related Risk Factors of Cognitive Impairment in Patients With Heart FailureYangyang Jiang0Lei Wang1Ziwen Lu2Shiqi Chen3Yu Teng4Tong Li5Yang Li6Yingzhen Xie7Mingjing Zhao8Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, ChinaKey Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, ChinaKey Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, ChinaKey Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, ChinaKey Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, ChinaKey Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, ChinaKey Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Encephalopathy, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, ChinaKey Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, ChinaBackground/AimsTo explore the imaging changes and related risk factors of heart failure (HF) patients with cognitive impairment (CI).MethodsA literature search was systematically carried out in PubMed, Web of Science, Embase, and Cochrane Library. In this systematic review, important relevant information was extracted according to the inclusion and exclusion criteria. The methodological quality was assessed by three scales according to the different study types.ResultsFinally, 66 studies were included, involving 33,579 patients. In the imaging changes, the severity of medial temporal lobe atrophy (MTA) and the decrease of gray Matter (GM) volume were closely related to the cognitive decline. The reduction of cerebral blood flow (CBF) may be correlated with CI. However, the change of white matter (WM) volume was possibly independent of CI in HF patients. Specific risk factors were analyzed, and the data indicated that the increased levels of B-type natriuretic peptide (BNP)/N-terminal pro-B-type natriuretic peptide (NT-proBNP), and the comorbidities of HF, including atrial fibrillation (AF), diabetes mellitus (DM) and anemia were definitely correlated with CI in patients with HF, respectively. Certain studies had also obtained independent correlation results. Body mass index (BMI), depression and sleep disorder exhibited a tendency to be associated with CI. Low ejection fraction (EF) value (<30%) was inclined to be associated with the decline in cognitive function. However, no significant differences were noted between heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF) in cognitive scores.ConclusionBNP/NT-proBNP and the comorbidities of HF including AF, DM and anemia were inextricably correlated with CI in patients with HF, respectively. These parameters were independent factors. The severity of MTA, GM volume, BMI index, depression, sleep disorder, and low EF value (<30%) have a disposition to associated with CI. The reduction in the CBF volume may be related to CI, whereas the WM volume may not be associated with CI in HF patients. The present systematic review provides an important basis for the prevention and treatment of CI following HF.https://www.frontiersin.org/articles/10.3389/fcvm.2021.838680/fullheart failurecognitive impairmentbrain imagingrisk factorssystematic review |
| spellingShingle | Yangyang Jiang Lei Wang Ziwen Lu Shiqi Chen Yu Teng Tong Li Yang Li Yingzhen Xie Mingjing Zhao Brain Imaging Changes and Related Risk Factors of Cognitive Impairment in Patients With Heart Failure Frontiers in Cardiovascular Medicine heart failure cognitive impairment brain imaging risk factors systematic review |
| title | Brain Imaging Changes and Related Risk Factors of Cognitive Impairment in Patients With Heart Failure |
| title_full | Brain Imaging Changes and Related Risk Factors of Cognitive Impairment in Patients With Heart Failure |
| title_fullStr | Brain Imaging Changes and Related Risk Factors of Cognitive Impairment in Patients With Heart Failure |
| title_full_unstemmed | Brain Imaging Changes and Related Risk Factors of Cognitive Impairment in Patients With Heart Failure |
| title_short | Brain Imaging Changes and Related Risk Factors of Cognitive Impairment in Patients With Heart Failure |
| title_sort | brain imaging changes and related risk factors of cognitive impairment in patients with heart failure |
| topic | heart failure cognitive impairment brain imaging risk factors systematic review |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.838680/full |
| work_keys_str_mv | AT yangyangjiang brainimagingchangesandrelatedriskfactorsofcognitiveimpairmentinpatientswithheartfailure AT leiwang brainimagingchangesandrelatedriskfactorsofcognitiveimpairmentinpatientswithheartfailure AT ziwenlu brainimagingchangesandrelatedriskfactorsofcognitiveimpairmentinpatientswithheartfailure AT shiqichen brainimagingchangesandrelatedriskfactorsofcognitiveimpairmentinpatientswithheartfailure AT yuteng brainimagingchangesandrelatedriskfactorsofcognitiveimpairmentinpatientswithheartfailure AT tongli brainimagingchangesandrelatedriskfactorsofcognitiveimpairmentinpatientswithheartfailure AT yangli brainimagingchangesandrelatedriskfactorsofcognitiveimpairmentinpatientswithheartfailure AT yingzhenxie brainimagingchangesandrelatedriskfactorsofcognitiveimpairmentinpatientswithheartfailure AT mingjingzhao brainimagingchangesandrelatedriskfactorsofcognitiveimpairmentinpatientswithheartfailure |