Stereoselective Synthesis and Antiproliferative Activity of Steviol-Based Diterpene 1,3-Aminoalcohol Regioisomers

Stereoselective Synthesis and Antiproliferative Activity of Steviol-Based Diterpene 1,3-Aminoalcohol Regioisomers

A series of novel diterpene-type 1,3-aminoalcohols and their regioisomers have been synthesised from natural stevioside in a stereoselective manner. The key intermediate β-keto alcohol was prepared using Wagner–Meerwein rearrangement of the epoxide derived from steviol methyl ester. The primary amin...

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Bibliographic Details
Main Authors: Dorottya Bai, Zsuzsanna Schelz, Mária Fanni Boncz, István Zupkó, Zsolt Szakonyi
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Molecules
Subjects:
diterpene
steviol
aminoalcohol
stereoselective
regioisomer
antiproliferative activity
Online Access:https://www.mdpi.com/1420-3049/28/24/7962

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