Exercise training as S-Klotho protein stimulator in sedentary healthy adults: Rationale, design, and methodology
Aims: The secreted form of the α-Klotho gene (S-Klotho), which is considered a powerful biomarker of longevity, makes it an attractive target as an anti-ageing therapy against functional decline, sarcopenic obesity, metabolic and cardiovascular diseases, osteoporosis, and neurodegenerative disorders...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-09-01
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| Series: | Contemporary Clinical Trials Communications |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451865418300310 |
| _version_ | 1818160099300999168 |
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| author | Francisco J. Amaro-Gahete Alejandro De-la-O Lucas Jurado-Fasoli Andrea Espuch-Oliver Lidia Robles-Gonzalez Ginés Navarro-Lomas Tomás de Haro Pedro Femia Manuel J. Castillo Angel Gutierrez |
| author_facet | Francisco J. Amaro-Gahete Alejandro De-la-O Lucas Jurado-Fasoli Andrea Espuch-Oliver Lidia Robles-Gonzalez Ginés Navarro-Lomas Tomás de Haro Pedro Femia Manuel J. Castillo Angel Gutierrez |
| author_sort | Francisco J. Amaro-Gahete |
| collection | DOAJ |
| description | Aims: The secreted form of the α-Klotho gene (S-Klotho), which is considered a powerful biomarker of longevity, makes it an attractive target as an anti-ageing therapy against functional decline, sarcopenic obesity, metabolic and cardiovascular diseases, osteoporosis, and neurodegenerative disorders. The S-Klotho plasma levels could be related to physical exercise inasmuch physical exercise is involved in physiological pathways that regulate the S-Klotho plasma levels. FIT-AGEING will determine the effect of different training modalities on the S-Klotho plasma levels (primary outcome) in sedentary healthy adults. FIT-AGEING will also investigate the physiological consequences of activating the klotho gene (secondary outcomes). Methods: FIT-AGEING will recruit 80 sedentary, healthy adults (50% women) aged 45–65 years old. Eligible participants will be randomly assigned to a non-exercise group, i.e. the control group, (n = 20), a physical activity recommendation from World Health Organization group (n = 20), a high intensity interval training group (n = 20), and a whole-body electromyostimulation group (n = 20). The laboratory measurements will be taken at the baseline and 12 weeks later including the S-Klotho plasma levels, physical fitness (cardiorespiratory fitness, muscular strength), body composition, basal metabolic rate, heart rate variability, maximal fat oxidation, health blood biomarkers, free-living physical activity, sleep habits, reaction time, cognitive variables, and health-related questionnaires. We will also obtain dietary habits data and cardiovascular disease risk factors. |
| first_indexed | 2024-12-11T15:56:29Z |
| format | Article |
| id | doaj.art-6a7b343f9a814476bbbc3760a1f62549 |
| institution | Directory Open Access Journal |
| issn | 2451-8654 |
| language | English |
| last_indexed | 2024-12-11T15:56:29Z |
| publishDate | 2018-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Contemporary Clinical Trials Communications |
| spelling | doaj.art-6a7b343f9a814476bbbc3760a1f625492022-12-22T00:59:26ZengElsevierContemporary Clinical Trials Communications2451-86542018-09-01111019Exercise training as S-Klotho protein stimulator in sedentary healthy adults: Rationale, design, and methodologyFrancisco J. Amaro-Gahete0Alejandro De-la-O1Lucas Jurado-Fasoli2Andrea Espuch-Oliver3Lidia Robles-Gonzalez4Ginés Navarro-Lomas5Tomás de Haro6Pedro Femia7Manuel J. Castillo8Angel Gutierrez9Department of Medical Physiology, School of Medicine, University of Granada, Spain; PROmoting FITness and Health Through Physical Activity Research Group (PROFITH), Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Spain; Corresponding author. Department of Medical Physiology, University of Granada, Granada, Spain.Department of Medical Physiology, School of Medicine, University of Granada, SpainDepartment of Medical Physiology, School of Medicine, University of Granada, SpainUnidad de Gestión Clínica de Laboratorios Clínicos, Hospital, H.U. Virgen de Las Nieves, Ibs.Granada, Complejo Hospitalario de Granada, 18016, Granada, SpainDepartment of Medical Physiology, School of Medicine, University of Granada, SpainDepartment of Medical Physiology, School of Medicine, University of Granada, SpainUnidad de Gestión Clínica de Laboratorios Clínicos, H.U San Cecilio, Ibs.Granada, Complejo Hospitalario de Granada, 18016, Granada, SpainDepartment of Statistics, Faculty of Medicine at the University of Granada, Granada, SpainDepartment of Medical Physiology, School of Medicine, University of Granada, SpainDepartment of Medical Physiology, School of Medicine, University of Granada, SpainAims: The secreted form of the α-Klotho gene (S-Klotho), which is considered a powerful biomarker of longevity, makes it an attractive target as an anti-ageing therapy against functional decline, sarcopenic obesity, metabolic and cardiovascular diseases, osteoporosis, and neurodegenerative disorders. The S-Klotho plasma levels could be related to physical exercise inasmuch physical exercise is involved in physiological pathways that regulate the S-Klotho plasma levels. FIT-AGEING will determine the effect of different training modalities on the S-Klotho plasma levels (primary outcome) in sedentary healthy adults. FIT-AGEING will also investigate the physiological consequences of activating the klotho gene (secondary outcomes). Methods: FIT-AGEING will recruit 80 sedentary, healthy adults (50% women) aged 45–65 years old. Eligible participants will be randomly assigned to a non-exercise group, i.e. the control group, (n = 20), a physical activity recommendation from World Health Organization group (n = 20), a high intensity interval training group (n = 20), and a whole-body electromyostimulation group (n = 20). The laboratory measurements will be taken at the baseline and 12 weeks later including the S-Klotho plasma levels, physical fitness (cardiorespiratory fitness, muscular strength), body composition, basal metabolic rate, heart rate variability, maximal fat oxidation, health blood biomarkers, free-living physical activity, sleep habits, reaction time, cognitive variables, and health-related questionnaires. We will also obtain dietary habits data and cardiovascular disease risk factors.http://www.sciencedirect.com/science/article/pii/S2451865418300310 |
| spellingShingle | Francisco J. Amaro-Gahete Alejandro De-la-O Lucas Jurado-Fasoli Andrea Espuch-Oliver Lidia Robles-Gonzalez Ginés Navarro-Lomas Tomás de Haro Pedro Femia Manuel J. Castillo Angel Gutierrez Exercise training as S-Klotho protein stimulator in sedentary healthy adults: Rationale, design, and methodology Contemporary Clinical Trials Communications |
| title | Exercise training as S-Klotho protein stimulator in sedentary healthy adults: Rationale, design, and methodology |
| title_full | Exercise training as S-Klotho protein stimulator in sedentary healthy adults: Rationale, design, and methodology |
| title_fullStr | Exercise training as S-Klotho protein stimulator in sedentary healthy adults: Rationale, design, and methodology |
| title_full_unstemmed | Exercise training as S-Klotho protein stimulator in sedentary healthy adults: Rationale, design, and methodology |
| title_short | Exercise training as S-Klotho protein stimulator in sedentary healthy adults: Rationale, design, and methodology |
| title_sort | exercise training as s klotho protein stimulator in sedentary healthy adults rationale design and methodology |
| url | http://www.sciencedirect.com/science/article/pii/S2451865418300310 |
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