Mechanotransduction through adhesion molecules: Emerging roles in regulating the stem cell niche
Stem cells have been shown to play an important role in regenerative medicine due to their proliferative and differentiation potential. The challenge, however, lies in regulating and controlling their potential for this purpose. Stem cells are regulated by growth factors as well as an array of bioch...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.966662/full |
| _version_ | 1811209677636108288 |
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| author | Ryan Lim Avinanda Banerjee Ritusree Biswas Ritusree Biswas Anana Nandakumar Chari Srikala Raghavan Srikala Raghavan |
| author_facet | Ryan Lim Avinanda Banerjee Ritusree Biswas Ritusree Biswas Anana Nandakumar Chari Srikala Raghavan Srikala Raghavan |
| author_sort | Ryan Lim |
| collection | DOAJ |
| description | Stem cells have been shown to play an important role in regenerative medicine due to their proliferative and differentiation potential. The challenge, however, lies in regulating and controlling their potential for this purpose. Stem cells are regulated by growth factors as well as an array of biochemical and mechanical signals. While the role of biochemical signals and growth factors in regulating stem cell homeostasis is well explored, the role of mechanical signals has only just started to be investigated. Stem cells interact with their niche or to other stem cells via adhesion molecules that eventually transduce mechanical cues to maintain their homeostatic function. Here, we present a comprehensive review on our current understanding of the influence of the forces perceived by cell adhesion molecules on the regulation of stem cells. Additionally, we provide insights on how this deeper understanding of mechanobiology of stem cells has translated toward therapeutics. |
| first_indexed | 2024-04-12T04:43:19Z |
| format | Article |
| id | doaj.art-6a7c72131bbe40a0b8b40a342dbdbf87 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-12T04:43:19Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-6a7c72131bbe40a0b8b40a342dbdbf872022-12-22T03:47:33ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-09-011010.3389/fcell.2022.966662966662Mechanotransduction through adhesion molecules: Emerging roles in regulating the stem cell nicheRyan Lim0Avinanda Banerjee1Ritusree Biswas2Ritusree Biswas3Anana Nandakumar Chari4Srikala Raghavan5Srikala Raghavan6A∗STAR Skin Research Lab (ASRL), Agency for Science, Technology and Research (A*STAR) 8A Biomedical Grove, Singapore, SingaporeA∗STAR Skin Research Lab (ASRL), Agency for Science, Technology and Research (A*STAR) 8A Biomedical Grove, Singapore, SingaporeInstitute for Stem Cell Science and Regenerative Medicine (inStem), GKVK Campus, Bangalore, IndiaSastra University, Thanjavur, TN, IndiaA∗STAR Skin Research Lab (ASRL), Agency for Science, Technology and Research (A*STAR) 8A Biomedical Grove, Singapore, SingaporeA∗STAR Skin Research Lab (ASRL), Agency for Science, Technology and Research (A*STAR) 8A Biomedical Grove, Singapore, SingaporeInstitute for Stem Cell Science and Regenerative Medicine (inStem), GKVK Campus, Bangalore, IndiaStem cells have been shown to play an important role in regenerative medicine due to their proliferative and differentiation potential. The challenge, however, lies in regulating and controlling their potential for this purpose. Stem cells are regulated by growth factors as well as an array of biochemical and mechanical signals. While the role of biochemical signals and growth factors in regulating stem cell homeostasis is well explored, the role of mechanical signals has only just started to be investigated. Stem cells interact with their niche or to other stem cells via adhesion molecules that eventually transduce mechanical cues to maintain their homeostatic function. Here, we present a comprehensive review on our current understanding of the influence of the forces perceived by cell adhesion molecules on the regulation of stem cells. Additionally, we provide insights on how this deeper understanding of mechanobiology of stem cells has translated toward therapeutics.https://www.frontiersin.org/articles/10.3389/fcell.2022.966662/fullmechanotransductionstem cell nicheadhesion moleculesadherens junctionsfocal adhesiondisease and regenerative therapeutics |
| spellingShingle | Ryan Lim Avinanda Banerjee Ritusree Biswas Ritusree Biswas Anana Nandakumar Chari Srikala Raghavan Srikala Raghavan Mechanotransduction through adhesion molecules: Emerging roles in regulating the stem cell niche Frontiers in Cell and Developmental Biology mechanotransduction stem cell niche adhesion molecules adherens junctions focal adhesion disease and regenerative therapeutics |
| title | Mechanotransduction through adhesion molecules: Emerging roles in regulating the stem cell niche |
| title_full | Mechanotransduction through adhesion molecules: Emerging roles in regulating the stem cell niche |
| title_fullStr | Mechanotransduction through adhesion molecules: Emerging roles in regulating the stem cell niche |
| title_full_unstemmed | Mechanotransduction through adhesion molecules: Emerging roles in regulating the stem cell niche |
| title_short | Mechanotransduction through adhesion molecules: Emerging roles in regulating the stem cell niche |
| title_sort | mechanotransduction through adhesion molecules emerging roles in regulating the stem cell niche |
| topic | mechanotransduction stem cell niche adhesion molecules adherens junctions focal adhesion disease and regenerative therapeutics |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.966662/full |
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