Activation of PKCzeta and PKMzeta in the nucleus accumbens core is necessary for the retrieval, consolidation and reconsolidation of drug memory.
One of the greatest challenges in the treatment of substance dependence is to reverse the control that drug-associated stimuli have gained over the addict's behavior, as these drug-associated memories increase the risk of relapse even after long periods of abstinence. We report here that inhibi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22348011/pdf/?tool=EBI |
| _version_ | 1830084933161320448 |
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| author | Jose A Crespo Petra Stöckl Florian Ueberall Marcel Jenny Alois Saria Gerald Zernig |
| author_facet | Jose A Crespo Petra Stöckl Florian Ueberall Marcel Jenny Alois Saria Gerald Zernig |
| author_sort | Jose A Crespo |
| collection | DOAJ |
| description | One of the greatest challenges in the treatment of substance dependence is to reverse the control that drug-associated stimuli have gained over the addict's behavior, as these drug-associated memories increase the risk of relapse even after long periods of abstinence. We report here that inhibition of the atypical protein kinase C isoform PKCzeta and its constitutively active isoform PKMzeta with the pseudosubstrate inhibitor ZIP administered locally into the nucleus accumbens core reversibly inhibited the retrieval of drug-associated memory and drug (remifentanil) seeking, whereas a scrambled ZIP peptide or staurosporine, an effective inhibitor of c/nPKC-, CaMKII-, and PKA kinases that does not affect PKCzeta/PKMzeta activity, was without effect on these memory processes. Acquisition or extinction of drug-associated memory remained unaffected by PKCzeta- and PKMzeta inhibition. |
| first_indexed | 2024-12-14T16:51:33Z |
| format | Article |
| id | doaj.art-6a7cc882399342fd8bd71a1911067039 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T16:51:33Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6a7cc882399342fd8bd71a19110670392022-12-21T22:54:03ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0172e3050210.1371/journal.pone.0030502Activation of PKCzeta and PKMzeta in the nucleus accumbens core is necessary for the retrieval, consolidation and reconsolidation of drug memory.Jose A CrespoPetra StöcklFlorian UeberallMarcel JennyAlois SariaGerald ZernigOne of the greatest challenges in the treatment of substance dependence is to reverse the control that drug-associated stimuli have gained over the addict's behavior, as these drug-associated memories increase the risk of relapse even after long periods of abstinence. We report here that inhibition of the atypical protein kinase C isoform PKCzeta and its constitutively active isoform PKMzeta with the pseudosubstrate inhibitor ZIP administered locally into the nucleus accumbens core reversibly inhibited the retrieval of drug-associated memory and drug (remifentanil) seeking, whereas a scrambled ZIP peptide or staurosporine, an effective inhibitor of c/nPKC-, CaMKII-, and PKA kinases that does not affect PKCzeta/PKMzeta activity, was without effect on these memory processes. Acquisition or extinction of drug-associated memory remained unaffected by PKCzeta- and PKMzeta inhibition.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22348011/pdf/?tool=EBI |
| spellingShingle | Jose A Crespo Petra Stöckl Florian Ueberall Marcel Jenny Alois Saria Gerald Zernig Activation of PKCzeta and PKMzeta in the nucleus accumbens core is necessary for the retrieval, consolidation and reconsolidation of drug memory. PLoS ONE |
| title | Activation of PKCzeta and PKMzeta in the nucleus accumbens core is necessary for the retrieval, consolidation and reconsolidation of drug memory. |
| title_full | Activation of PKCzeta and PKMzeta in the nucleus accumbens core is necessary for the retrieval, consolidation and reconsolidation of drug memory. |
| title_fullStr | Activation of PKCzeta and PKMzeta in the nucleus accumbens core is necessary for the retrieval, consolidation and reconsolidation of drug memory. |
| title_full_unstemmed | Activation of PKCzeta and PKMzeta in the nucleus accumbens core is necessary for the retrieval, consolidation and reconsolidation of drug memory. |
| title_short | Activation of PKCzeta and PKMzeta in the nucleus accumbens core is necessary for the retrieval, consolidation and reconsolidation of drug memory. |
| title_sort | activation of pkczeta and pkmzeta in the nucleus accumbens core is necessary for the retrieval consolidation and reconsolidation of drug memory |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22348011/pdf/?tool=EBI |
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