The Link between Autosomal Dominant Polycystic Kidney Disease and Chromosomal Instability: Exploring the Relationship

The Link between Autosomal Dominant Polycystic Kidney Disease and Chromosomal Instability: Exploring the Relationship

In autosomal dominant polycystic kidney disease (ADPKD) with germline mutations in a <i>PKD1</i> or <i>PKD2</i> gene, innumerable cysts develop from tubules, and renal function deteriorates. Second-hit somatic mutations and renal tubular epithelial (RTE) cell death are crucia...

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Bibliographic Details
Main Authors: Phang-Lang Chen, Chi-Fen Chen, Hugo Y.-H. Lin, Daniel J. Riley, Yumay Chen
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:International Journal of Molecular Sciences
Subjects:
ADPKD
DNA damage repair
checkpoint
PKD1
PKD2
CHK1
Online Access:https://www.mdpi.com/1422-0067/25/5/2936

Internet

https://www.mdpi.com/1422-0067/25/5/2936

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