The Link between Autosomal Dominant Polycystic Kidney Disease and Chromosomal Instability: Exploring the Relationship
In autosomal dominant polycystic kidney disease (ADPKD) with germline mutations in a <i>PKD1</i> or <i>PKD2</i> gene, innumerable cysts develop from tubules, and renal function deteriorates. Second-hit somatic mutations and renal tubular epithelial (RTE) cell death are crucia...
Main Authors: | Phang-Lang Chen, Chi-Fen Chen, Hugo Y.-H. Lin, Daniel J. Riley, Yumay Chen |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2024-03-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/25/5/2936 |
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