Diagnostic Accuracy of Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas
Line-field confocal optical coherence tomography (LC-OCT) is a new, noninvasive imaging technique for the diagnosis of skin cancers. A total of 243 benign (54%) and malignant (46%) skin lesions were consecutively enrolled from 27 August 2020, to 6 October 2021 at the Dermatology Department of the Un...
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MDPI AG
2023-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/3/361 |
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| author | Elisa Cinotti Tullio Brunetti Alessandra Cartocci Linda Tognetti Mariano Suppa Josep Malvehy Javiera Perez-Anker Susanna Puig Jean Luc Perrot Pietro Rubegni |
| author_facet | Elisa Cinotti Tullio Brunetti Alessandra Cartocci Linda Tognetti Mariano Suppa Josep Malvehy Javiera Perez-Anker Susanna Puig Jean Luc Perrot Pietro Rubegni |
| author_sort | Elisa Cinotti |
| collection | DOAJ |
| description | Line-field confocal optical coherence tomography (LC-OCT) is a new, noninvasive imaging technique for the diagnosis of skin cancers. A total of 243 benign (54%) and malignant (46%) skin lesions were consecutively enrolled from 27 August 2020, to 6 October 2021 at the Dermatology Department of the University Hospital of Siena, Italy. Dermoscopic- and LC-OCT-based diagnoses were given by an expert dermatologist and compared with the ground truth. Considering all types of malignant skin tumours (79 basal cell carcinomas (BCCs), 22 squamous cell carcinomas, and 10 melanomas), a statistically significant increase (<i>p</i> = 0.013) in specificity was observed from dermoscopy (0.73, CI 0.64–0.81) to LC-OCT (0.87, CI 0.79–0.93) while sensitivity was the same with the two imaging techniques (0.95 CI 0.89–0.98 for dermoscopy and 0.95 CI 0.90–0.99 for LC-OCT). The increase in specificity was mainly driven by the ability of LC-OCT to differentiate BCCs from other diagnoses. In conclusion, our real-life study showed that LC-OCT can play an important role in helping the noninvasive diagnosis of malignant skin neoplasms and especially of BCCs. LC-OCT could be positioned after the dermoscopic examination, to spare useless biopsy of benign lesions without decreasing sensitivity. |
| first_indexed | 2024-03-11T09:49:07Z |
| format | Article |
| id | doaj.art-6a804de5ca6148b9bd1e3dec6bc71a58 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T09:49:07Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-6a804de5ca6148b9bd1e3dec6bc71a582023-11-16T16:23:36ZengMDPI AGDiagnostics2075-44182023-01-0113336110.3390/diagnostics13030361Diagnostic Accuracy of Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin CarcinomasElisa Cinotti0Tullio Brunetti1Alessandra Cartocci2Linda Tognetti3Mariano Suppa4Josep Malvehy5Javiera Perez-Anker6Susanna Puig7Jean Luc Perrot8Pietro Rubegni9Department of Medical, Surgical and Neurological Sciences, Dermatology Section, University of Siena, 53100 Siena, ItalyDepartment of Medical, Surgical and Neurological Sciences, Dermatology Section, University of Siena, 53100 Siena, ItalyDepartment of Medical, Surgical and Neurological Sciences, Dermatology Section, University of Siena, 53100 Siena, ItalyDepartment of Medical, Surgical and Neurological Sciences, Dermatology Section, University of Siena, 53100 Siena, ItalyGroupe d’Imagerie Cutanée Non Invasive (GICNI), Société Française de Dermatologie (SFD), 75008 Paris, FranceMelanoma Unit, Hospital Clinic Barcelona, University of Barcelona, 08007 Barcelona, SpainMelanoma Unit, Hospital Clinic Barcelona, University of Barcelona, 08007 Barcelona, SpainMelanoma Unit, Hospital Clinic Barcelona, University of Barcelona, 08007 Barcelona, SpainDepartment of Dermatology, University Hospital of St-Etienne, 42270 Saint-Etienne, FranceDepartment of Medical, Surgical and Neurological Sciences, Dermatology Section, University of Siena, 53100 Siena, ItalyLine-field confocal optical coherence tomography (LC-OCT) is a new, noninvasive imaging technique for the diagnosis of skin cancers. A total of 243 benign (54%) and malignant (46%) skin lesions were consecutively enrolled from 27 August 2020, to 6 October 2021 at the Dermatology Department of the University Hospital of Siena, Italy. Dermoscopic- and LC-OCT-based diagnoses were given by an expert dermatologist and compared with the ground truth. Considering all types of malignant skin tumours (79 basal cell carcinomas (BCCs), 22 squamous cell carcinomas, and 10 melanomas), a statistically significant increase (<i>p</i> = 0.013) in specificity was observed from dermoscopy (0.73, CI 0.64–0.81) to LC-OCT (0.87, CI 0.79–0.93) while sensitivity was the same with the two imaging techniques (0.95 CI 0.89–0.98 for dermoscopy and 0.95 CI 0.90–0.99 for LC-OCT). The increase in specificity was mainly driven by the ability of LC-OCT to differentiate BCCs from other diagnoses. In conclusion, our real-life study showed that LC-OCT can play an important role in helping the noninvasive diagnosis of malignant skin neoplasms and especially of BCCs. LC-OCT could be positioned after the dermoscopic examination, to spare useless biopsy of benign lesions without decreasing sensitivity.https://www.mdpi.com/2075-4418/13/3/361optical coherence tomographytumorbasal cell carcinomaimagingsquamous cell carcinoma |
| spellingShingle | Elisa Cinotti Tullio Brunetti Alessandra Cartocci Linda Tognetti Mariano Suppa Josep Malvehy Javiera Perez-Anker Susanna Puig Jean Luc Perrot Pietro Rubegni Diagnostic Accuracy of Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas Diagnostics optical coherence tomography tumor basal cell carcinoma imaging squamous cell carcinoma |
| title | Diagnostic Accuracy of Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas |
| title_full | Diagnostic Accuracy of Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas |
| title_fullStr | Diagnostic Accuracy of Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas |
| title_full_unstemmed | Diagnostic Accuracy of Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas |
| title_short | Diagnostic Accuracy of Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas |
| title_sort | diagnostic accuracy of line field confocal optical coherence tomography for the diagnosis of skin carcinomas |
| topic | optical coherence tomography tumor basal cell carcinoma imaging squamous cell carcinoma |
| url | https://www.mdpi.com/2075-4418/13/3/361 |
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