Outcome and current status of therapeutic hypothermia after out-of-hospital cardiac arrest in Korea using data from the Korea Hypothermia Network registry
ObjectiveTherapeutic hypothermia (TH) has become the standard strategy for reducing brain damage in the postresuscitation period. The aim of this study was to investigate current TH performance and outcomes in out-of-hospital cardiac arrest (OHCA) survivors using data from the Korean Hypothermia Net...
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| Format: | Article |
| Language: | English |
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The Korean Society of Emergency Medicine
2014-09-01
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| Series: | Clinical and Experimental Emergency Medicine |
| Subjects: | |
| Online Access: | http://www.ceemjournal.org/upload/pdf/ceem-14-007.pdf |
| _version_ | 1797897230933295104 |
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| author | Byung Kook Lee Kyu Nam Park Gu Hyun Kang Kyung Hwan Kim Giwoon Kim Won Young Kim Jin Hong Min Yooseok Park Jung Bae Park Gil Joon Suh Yoo Dong Son Jonghwan Shin Joo Suk Oh Yeon Ho You Dong Hoon Lee Jong Seok Lee Hoon Lim Tae Chang Jang Gyu Chong Cho In Soo Cho Kyoung Chul Cha Seung Pill Choi Wook Jin Choi Chul Han |
| author_facet | Byung Kook Lee Kyu Nam Park Gu Hyun Kang Kyung Hwan Kim Giwoon Kim Won Young Kim Jin Hong Min Yooseok Park Jung Bae Park Gil Joon Suh Yoo Dong Son Jonghwan Shin Joo Suk Oh Yeon Ho You Dong Hoon Lee Jong Seok Lee Hoon Lim Tae Chang Jang Gyu Chong Cho In Soo Cho Kyoung Chul Cha Seung Pill Choi Wook Jin Choi Chul Han |
| author_sort | Byung Kook Lee |
| collection | DOAJ |
| description | ObjectiveTherapeutic hypothermia (TH) has become the standard strategy for reducing brain damage in the postresuscitation period. The aim of this study was to investigate current TH performance and outcomes in out-of-hospital cardiac arrest (OHCA) survivors using data from the Korean Hypothermia Network (KORHN) registry. MethodsWe used the KORHN registry, a web-based multicenter registry that includes 24 participating hospitals throughout the Republic of Korea. Adult comatose OHCA survivors treated with TH between 2007 and 2012 were included. The primary outcomes were neurological outcome at hospital discharge and in-hospital mortality. The secondary outcomes were TH performance and adverse events during TH. ResultsA total of 930 patients were included, of whom 556 (59.8%) survived to discharge and 249 (26.8%) were discharged with good neurologic outcomes. The median time from return of spontaneous circulation (ROSC) to the start of TH was 101 minutes (interquartile range [IQR], 46 to 200 minutes). The induction, maintenance, and rewarming durations were 150 minutes (IQR, 80 to 267 minutes), 1,440 minutes (IQR, 1,290 to 1,440 minutes), and 708 minutes (IQR, 420 to 900 minutes), respectively. The time from the ROSC to coronary angiography was 1,045 hours (IQR, 121 to 12,051 hours). Hyperglycemia (46.3%) was the most frequent adverse event. ConclusionMore than one-quarter of the OHCA survivors (26.8%) were discharged with good neurologic outcomes. TH performance was appropriately managed in terms of the factors related to its timing, including cooling start time and rewarming duration. |
| first_indexed | 2024-04-10T07:55:22Z |
| format | Article |
| id | doaj.art-6a80e35496d14afea1eca6dd6314505c |
| institution | Directory Open Access Journal |
| issn | 2383-4625 |
| language | English |
| last_indexed | 2024-04-10T07:55:22Z |
| publishDate | 2014-09-01 |
| publisher | The Korean Society of Emergency Medicine |
| record_format | Article |
| series | Clinical and Experimental Emergency Medicine |
| spelling | doaj.art-6a80e35496d14afea1eca6dd6314505c2023-02-23T05:22:08ZengThe Korean Society of Emergency MedicineClinical and Experimental Emergency Medicine2383-46252014-09-0111192710.15441/ceem.14.0073Outcome and current status of therapeutic hypothermia after out-of-hospital cardiac arrest in Korea using data from the Korea Hypothermia Network registryByung Kook Lee0Kyu Nam Park1Gu Hyun Kang2Kyung Hwan Kim3Giwoon Kim4Won Young Kim5Jin Hong Min6Yooseok Park7Jung Bae Park8Gil Joon Suh9Yoo Dong Son10Jonghwan Shin11Joo Suk Oh12Yeon Ho You13Dong Hoon Lee14Jong Seok Lee15Hoon Lim16Tae Chang Jang17Gyu Chong Cho18In Soo Cho19Kyoung Chul Cha20Seung Pill Choi21Wook Jin Choi22Chul Han23 Department of Emergency Medicine, Chonnam National University Medical School, Gwangju, Korea Department of Emergency Medicine, The Catholic University of Korea School of Medicine, Seoul, Korea Department of Emergency Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, Korea Department of Emergency Medicine, Inje University Ilsan Paik Hospital, Goyang, Korea Department of Emergency Medicine, Ajou University Hospital, Suwon, Korea Department of Emergency Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Emergency Medicine, Chungbuk National University College of Medicine, Cheongju, Korea Department of Emergency Medicine, Yonsei University College of Medicine, Seoul, Korea Department of Emergency Medicine, Kyungpook National University School of Medicine, Daegu, Korea Department of Emergency Medicine, Seoul National University College of Medicine, Seoul, Korea Department of Emergency Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea Department of Emergency Medicine, Seoul National University Boramae Medical Center, Seoul, Korea Department of Emergency Medicine, The Catholic University of Korea School of Medicine, Seoul, Korea Department of Emergency Medicine, Chungnam National University School of Medicine, Daejeon, Korea Department of Emergency Medicine, Chung-Ang University College of Medicine, Seoul, Korea Department of Emergency Medicine, Kyung Hee University School of Medicine, Seoul, Korea Department of Emergency Medicine, Soonchunhyang University College of Medicine, Bucheon, Korea Department of Emergency Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea Department of Emergency Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea Department of Emergency Medicine, Hanil General Hospital, Korea Electric Power Medical Corporation, Seoul, Korea Department of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea Department of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea Department of Emergency Medicine, Ulsan University College of Medicine, Ulsan, Korea Department of Emergency Medicine, Ewha Womans School of Medicine, Seoul, KoreaObjectiveTherapeutic hypothermia (TH) has become the standard strategy for reducing brain damage in the postresuscitation period. The aim of this study was to investigate current TH performance and outcomes in out-of-hospital cardiac arrest (OHCA) survivors using data from the Korean Hypothermia Network (KORHN) registry. MethodsWe used the KORHN registry, a web-based multicenter registry that includes 24 participating hospitals throughout the Republic of Korea. Adult comatose OHCA survivors treated with TH between 2007 and 2012 were included. The primary outcomes were neurological outcome at hospital discharge and in-hospital mortality. The secondary outcomes were TH performance and adverse events during TH. ResultsA total of 930 patients were included, of whom 556 (59.8%) survived to discharge and 249 (26.8%) were discharged with good neurologic outcomes. The median time from return of spontaneous circulation (ROSC) to the start of TH was 101 minutes (interquartile range [IQR], 46 to 200 minutes). The induction, maintenance, and rewarming durations were 150 minutes (IQR, 80 to 267 minutes), 1,440 minutes (IQR, 1,290 to 1,440 minutes), and 708 minutes (IQR, 420 to 900 minutes), respectively. The time from the ROSC to coronary angiography was 1,045 hours (IQR, 121 to 12,051 hours). Hyperglycemia (46.3%) was the most frequent adverse event. ConclusionMore than one-quarter of the OHCA survivors (26.8%) were discharged with good neurologic outcomes. TH performance was appropriately managed in terms of the factors related to its timing, including cooling start time and rewarming duration.http://www.ceemjournal.org/upload/pdf/ceem-14-007.pdfout-of-hospital cardiac arresthypothermia, inducedregistries |
| spellingShingle | Byung Kook Lee Kyu Nam Park Gu Hyun Kang Kyung Hwan Kim Giwoon Kim Won Young Kim Jin Hong Min Yooseok Park Jung Bae Park Gil Joon Suh Yoo Dong Son Jonghwan Shin Joo Suk Oh Yeon Ho You Dong Hoon Lee Jong Seok Lee Hoon Lim Tae Chang Jang Gyu Chong Cho In Soo Cho Kyoung Chul Cha Seung Pill Choi Wook Jin Choi Chul Han Outcome and current status of therapeutic hypothermia after out-of-hospital cardiac arrest in Korea using data from the Korea Hypothermia Network registry Clinical and Experimental Emergency Medicine out-of-hospital cardiac arrest hypothermia, induced registries |
| title | Outcome and current status of therapeutic hypothermia after out-of-hospital cardiac arrest in Korea using data from the Korea Hypothermia Network registry |
| title_full | Outcome and current status of therapeutic hypothermia after out-of-hospital cardiac arrest in Korea using data from the Korea Hypothermia Network registry |
| title_fullStr | Outcome and current status of therapeutic hypothermia after out-of-hospital cardiac arrest in Korea using data from the Korea Hypothermia Network registry |
| title_full_unstemmed | Outcome and current status of therapeutic hypothermia after out-of-hospital cardiac arrest in Korea using data from the Korea Hypothermia Network registry |
| title_short | Outcome and current status of therapeutic hypothermia after out-of-hospital cardiac arrest in Korea using data from the Korea Hypothermia Network registry |
| title_sort | outcome and current status of therapeutic hypothermia after out of hospital cardiac arrest in korea using data from the korea hypothermia network registry |
| topic | out-of-hospital cardiac arrest hypothermia, induced registries |
| url | http://www.ceemjournal.org/upload/pdf/ceem-14-007.pdf |
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