Curcumin inhibits glyoxalase 1: a possible link to its anti-inflammatory and anti-tumor activity.

Curcumin inhibits glyoxalase 1: a possible link to its anti-inflammatory and anti-tumor activity.

<h4>Background</h4>Glyoxalases (Glo1 and Glo2) are involved in the glycolytic pathway by detoxifying the reactive methylglyoxal (MGO) into D-lactate in a two-step reaction using glutathione (GSH) as cofactor. Inhibitors of glyoxalases are considered as anti-inflammatory and anti-carcinog...

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Main Authors: Thore Santel, Gabi Pflug, Nasr Y A Hemdan, Angelika Schäfer, Marcus Hollenbach, Martin Buchold, Anja Hintersdorf, Inge Lindner, Andreas Otto, Marina Bigl, Ilka Oerlecke, Antje Hutschenreuther, Ulrich Sack, Klaus Huse, Marco Groth, Claudia Birkemeyer, Wolfgang Schellenberger, Rolf Gebhardt, Mathias Platzer, Thomas Weiss, Mookambeswaran A Vijayalakshmi, Monika Krüger, Gerd Birkenmeier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18946510/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18946510/pdf/?tool=EBI

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