Tityus serrulatus envenoming in non-obese diabetic mice: a risk factor for severity
Abstract Background In Brazil, accidents with venomous animals are considered a public health problem. Tityus serrulatus (Ts), popularly known as the yellow scorpion, is most frequently responsible for the severe accidents in the country. Ts envenoming can cause several signs and symptoms classifi...
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| Format: | Article |
| Language: | English |
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SciELO
2016-10-01
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| Series: | Journal of Venomous Animals and Toxins including Tropical Diseases |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100319&lng=en&tlng=en |
| _version_ | 1818194455995351040 |
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| author | Guilherme Honda de Oliveira Felipe Augusto Cerni Iara Aimê Cardoso Eliane Candiani Arantes Manuela Berto Pucca |
| author_facet | Guilherme Honda de Oliveira Felipe Augusto Cerni Iara Aimê Cardoso Eliane Candiani Arantes Manuela Berto Pucca |
| author_sort | Guilherme Honda de Oliveira |
| collection | DOAJ |
| description | Abstract Background In Brazil, accidents with venomous animals are considered a public health problem. Tityus serrulatus (Ts), popularly known as the yellow scorpion, is most frequently responsible for the severe accidents in the country. Ts envenoming can cause several signs and symptoms classified according to their clinical manifestations as mild, moderate or severe. Furthermore, the victims usually present biochemical alterations, including hyperglycemia. Nevertheless, Ts envenoming and its induced hyperglycemia were never studied or documented in a patient with diabetes mellitus (DM). Therefore, this is the first study to evaluate the glycemia during Ts envenoming using a diabetic animal model (NOD, non-obese diabetic). Methods Female mice (BALB/c or NOD) were challenged with a non-lethal dose of Ts venom. Blood glucose level was measured (tail blood using a glucose meter) over a 24-h period. The total glycosylated hemoglobin (HbA1c) levels were measured 30 days after Ts venom injection. Moreover, the insulin levels were analyzed at the glycemia peak. Results The results demonstrated that the envenomed NOD animals presented a significant increase of glycemia, glycosylated hemoglobin (HbA1c) and insulin levels compared to the envenomed BALB/c control group, corroborating that DM victims present great risk of developing severe envenoming. Moreover, the envenomed NOD animals presented highest risk of death and sequelae. Conclusions This study demonstrated that the diabetic victims stung by Ts scorpion should be always considered a risk group for scorpion envenoming severity. |
| first_indexed | 2024-12-12T01:02:34Z |
| format | Article |
| id | doaj.art-6a86a9eeb8344be2b98a26948040cd7b |
| institution | Directory Open Access Journal |
| issn | 1678-9199 |
| language | English |
| last_indexed | 2024-12-12T01:02:34Z |
| publishDate | 2016-10-01 |
| publisher | SciELO |
| record_format | Article |
| series | Journal of Venomous Animals and Toxins including Tropical Diseases |
| spelling | doaj.art-6a86a9eeb8344be2b98a26948040cd7b2022-12-22T00:43:40ZengSciELOJournal of Venomous Animals and Toxins including Tropical Diseases1678-91992016-10-0122010.1186/s40409-016-0081-8S1678-91992016000100319Tityus serrulatus envenoming in non-obese diabetic mice: a risk factor for severityGuilherme Honda de OliveiraFelipe Augusto CerniIara Aimê CardosoEliane Candiani ArantesManuela Berto PuccaAbstract Background In Brazil, accidents with venomous animals are considered a public health problem. Tityus serrulatus (Ts), popularly known as the yellow scorpion, is most frequently responsible for the severe accidents in the country. Ts envenoming can cause several signs and symptoms classified according to their clinical manifestations as mild, moderate or severe. Furthermore, the victims usually present biochemical alterations, including hyperglycemia. Nevertheless, Ts envenoming and its induced hyperglycemia were never studied or documented in a patient with diabetes mellitus (DM). Therefore, this is the first study to evaluate the glycemia during Ts envenoming using a diabetic animal model (NOD, non-obese diabetic). Methods Female mice (BALB/c or NOD) were challenged with a non-lethal dose of Ts venom. Blood glucose level was measured (tail blood using a glucose meter) over a 24-h period. The total glycosylated hemoglobin (HbA1c) levels were measured 30 days after Ts venom injection. Moreover, the insulin levels were analyzed at the glycemia peak. Results The results demonstrated that the envenomed NOD animals presented a significant increase of glycemia, glycosylated hemoglobin (HbA1c) and insulin levels compared to the envenomed BALB/c control group, corroborating that DM victims present great risk of developing severe envenoming. Moreover, the envenomed NOD animals presented highest risk of death and sequelae. Conclusions This study demonstrated that the diabetic victims stung by Ts scorpion should be always considered a risk group for scorpion envenoming severity.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100319&lng=en&tlng=enTityus serrulatusDiabetes mellitusScorpion venomNOD miceGlycemia |
| spellingShingle | Guilherme Honda de Oliveira Felipe Augusto Cerni Iara Aimê Cardoso Eliane Candiani Arantes Manuela Berto Pucca Tityus serrulatus envenoming in non-obese diabetic mice: a risk factor for severity Journal of Venomous Animals and Toxins including Tropical Diseases Tityus serrulatus Diabetes mellitus Scorpion venom NOD mice Glycemia |
| title | Tityus serrulatus envenoming in non-obese diabetic mice: a risk factor for severity |
| title_full | Tityus serrulatus envenoming in non-obese diabetic mice: a risk factor for severity |
| title_fullStr | Tityus serrulatus envenoming in non-obese diabetic mice: a risk factor for severity |
| title_full_unstemmed | Tityus serrulatus envenoming in non-obese diabetic mice: a risk factor for severity |
| title_short | Tityus serrulatus envenoming in non-obese diabetic mice: a risk factor for severity |
| title_sort | tityus serrulatus envenoming in non obese diabetic mice a risk factor for severity |
| topic | Tityus serrulatus Diabetes mellitus Scorpion venom NOD mice Glycemia |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100319&lng=en&tlng=en |
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