Histopathological Spectrum of Central Nervous System Tumours in Adolescent and Young Adults: A Cross-sectional Study from Punjab, Northern India
Introduction: Central Nervous System (CNS) tumours are a common cause of cancer-related deaths in adolescents and young adults. The challenges in diagnosing and treating CNS tumours in this age group are unique and require special attention. Aim: To study the histopathological spectrum of CNS tumou...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2024-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://www.jcdr.net/articles/PDF/19046/66363_CE[Ra1]_F(IS)_QC(SHK_RDW_IS)_PF1(AG_SS)_PFA(KM)_PB(AG_OM)_PN(OM).pdf |
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| author | Vikram Narang Gagandeep Singh Gursheen Puri Batta Ankita Soni Harpreet Kaur |
| author_facet | Vikram Narang Gagandeep Singh Gursheen Puri Batta Ankita Soni Harpreet Kaur |
| author_sort | Vikram Narang |
| collection | DOAJ |
| description | Introduction: Central Nervous System (CNS) tumours are a common cause of cancer-related deaths in adolescents and young adults. The challenges in diagnosing and treating CNS tumours in this age group are unique and require special attention.
Aim: To study the histopathological spectrum of CNS tumours in Adolescents and Young Adults (AYA).
Materials and Methods: Present five-year cross-sectional study was conducted on CNS biopsies received in the Department of Pathology at Dayanand Medical College and Hospital, Ludhiana, Punjab, India, from July 1, 2016, to June 30, 2021, to analyse the histopathological spectrum of CNS tumours in the AYA group based on the site of the lesion, age, gender, and Isocitrate Dehydrogenase (IDH) status.
Results: During the study period, a total of 215 cases of CNS tumours were identified, of which 52 (24.2%) belonged to the AYA group. Of these, 35 (67.3%) were males and 17 (32.7%) were females. The majority of the patients presented with complaints of headache (50/52, 96.1%), with the frontal lobe being the most common site of involvement (21/52, 40.4%). Diffuse astrocytic and oligodendroglial tumours were the most commonly observed (23/52, 44.2%).
Conclusion: CNS tumours are one of the most common cancer diagnosis among the AYA group, and awareness should be enhanced among histopathologists and oncologists regarding these tumours based on the updated classification. |
| first_indexed | 2024-03-08T04:45:47Z |
| format | Article |
| id | doaj.art-6a86d6a396d44efab4f95130baa37562 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-03-08T04:45:47Z |
| publishDate | 2024-02-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-6a86d6a396d44efab4f95130baa375622024-02-08T10:43:17ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2024-02-011802172010.7860/JCDR/2024/66363.19046Histopathological Spectrum of Central Nervous System Tumours in Adolescent and Young Adults: A Cross-sectional Study from Punjab, Northern IndiaVikram Narang0Gagandeep Singh1Gursheen Puri Batta2Ankita Soni3Harpreet Kaur4Professor, Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.Senior Resident, Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.Consultant, Department of Medicine, Oswal Cancer Hospital, Ludhiana, Punjab, India.Assistant Professor, Department of Pathology, AIIMS, Bathinda, Punjab, India.Professor and Head, Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.Introduction: Central Nervous System (CNS) tumours are a common cause of cancer-related deaths in adolescents and young adults. The challenges in diagnosing and treating CNS tumours in this age group are unique and require special attention. Aim: To study the histopathological spectrum of CNS tumours in Adolescents and Young Adults (AYA). Materials and Methods: Present five-year cross-sectional study was conducted on CNS biopsies received in the Department of Pathology at Dayanand Medical College and Hospital, Ludhiana, Punjab, India, from July 1, 2016, to June 30, 2021, to analyse the histopathological spectrum of CNS tumours in the AYA group based on the site of the lesion, age, gender, and Isocitrate Dehydrogenase (IDH) status. Results: During the study period, a total of 215 cases of CNS tumours were identified, of which 52 (24.2%) belonged to the AYA group. Of these, 35 (67.3%) were males and 17 (32.7%) were females. The majority of the patients presented with complaints of headache (50/52, 96.1%), with the frontal lobe being the most common site of involvement (21/52, 40.4%). Diffuse astrocytic and oligodendroglial tumours were the most commonly observed (23/52, 44.2%). Conclusion: CNS tumours are one of the most common cancer diagnosis among the AYA group, and awareness should be enhanced among histopathologists and oncologists regarding these tumours based on the updated classification.https://www.jcdr.net/articles/PDF/19046/66363_CE[Ra1]_F(IS)_QC(SHK_RDW_IS)_PF1(AG_SS)_PFA(KM)_PB(AG_OM)_PN(OM).pdfastrocytomabrain tumourglioblastomaintracranial space occupying lesionmeningiomaneoplasm |
| spellingShingle | Vikram Narang Gagandeep Singh Gursheen Puri Batta Ankita Soni Harpreet Kaur Histopathological Spectrum of Central Nervous System Tumours in Adolescent and Young Adults: A Cross-sectional Study from Punjab, Northern India Journal of Clinical and Diagnostic Research astrocytoma brain tumour glioblastoma intracranial space occupying lesion meningioma neoplasm |
| title | Histopathological Spectrum of Central Nervous System Tumours in Adolescent and Young Adults: A Cross-sectional Study from Punjab, Northern India |
| title_full | Histopathological Spectrum of Central Nervous System Tumours in Adolescent and Young Adults: A Cross-sectional Study from Punjab, Northern India |
| title_fullStr | Histopathological Spectrum of Central Nervous System Tumours in Adolescent and Young Adults: A Cross-sectional Study from Punjab, Northern India |
| title_full_unstemmed | Histopathological Spectrum of Central Nervous System Tumours in Adolescent and Young Adults: A Cross-sectional Study from Punjab, Northern India |
| title_short | Histopathological Spectrum of Central Nervous System Tumours in Adolescent and Young Adults: A Cross-sectional Study from Punjab, Northern India |
| title_sort | histopathological spectrum of central nervous system tumours in adolescent and young adults a cross sectional study from punjab northern india |
| topic | astrocytoma brain tumour glioblastoma intracranial space occupying lesion meningioma neoplasm |
| url | https://www.jcdr.net/articles/PDF/19046/66363_CE[Ra1]_F(IS)_QC(SHK_RDW_IS)_PF1(AG_SS)_PFA(KM)_PB(AG_OM)_PN(OM).pdf |
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