Downregulated miR-150-5p in the Tissue of Nasopharyngeal Carcinoma
The clinical significance and potential targets of miR-150-5p have not been elucidated in nasopharyngeal carcinoma (NPC). The pooled analysis based on 539 NPC samples and 75 non-NPC nasopharyngeal samples demonstrated that the expression of miR-150-5p was down-regulated in NPC, with the area under t...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi - Cambridge University Press
2022-01-01
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| Series: | Genetics Research |
| Online Access: | http://dx.doi.org/10.1155/2022/2485055 |
| _version_ | 1797994895923740672 |
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| author | Jia-Ying Wen Gang Chen Jian-Di Li Jia-Yuan Luo Juan He Ren-Sheng Wang Li-Ting Qin |
| author_facet | Jia-Ying Wen Gang Chen Jian-Di Li Jia-Yuan Luo Juan He Ren-Sheng Wang Li-Ting Qin |
| author_sort | Jia-Ying Wen |
| collection | DOAJ |
| description | The clinical significance and potential targets of miR-150-5p have not been elucidated in nasopharyngeal carcinoma (NPC). The pooled analysis based on 539 NPC samples and 75 non-NPC nasopharyngeal samples demonstrated that the expression of miR-150-5p was down-regulated in NPC, with the area under the curve being 0.89 and the standardized mean difference being −0.66. Subsequently, we further screened the differentially expressed genes (DEGs) of 14 datasets, including 312 NPC samples and 70 non-NPC nasopharyngeal samples. After the DEGs were narrowed down with the predicted targets from the miRWalk database, 1316 prospective target genes of miR-150-5p were identified. The enrichment analysis suggested that “pathways in cancer” was the most significant pathway. Finally, six hub genes of “pathways in cancer”, including EGFR, TP53, HRAS, CCND1, CDH1, and FGF2, were screened out through the STRING database. In conclusion, the down-regulation of miR-150-5p modulates the tumorigenesis and progression of NPC. |
| first_indexed | 2024-04-11T09:53:05Z |
| format | Article |
| id | doaj.art-6a878c6aedb94e61bec510ea5b125d63 |
| institution | Directory Open Access Journal |
| issn | 1469-5073 |
| language | English |
| last_indexed | 2024-04-11T09:53:05Z |
| publishDate | 2022-01-01 |
| publisher | Hindawi - Cambridge University Press |
| record_format | Article |
| series | Genetics Research |
| spelling | doaj.art-6a878c6aedb94e61bec510ea5b125d632022-12-22T04:30:45ZengHindawi - Cambridge University PressGenetics Research1469-50732022-01-01202210.1155/2022/2485055Downregulated miR-150-5p in the Tissue of Nasopharyngeal CarcinomaJia-Ying Wen0Gang Chen1Jian-Di Li2Jia-Yuan Luo3Juan He4Ren-Sheng Wang5Li-Ting Qin6Department of RadiotherapyDepartment of PathologyDepartment of PathologyDepartment of PathologyDepartment of PathologyDepartment of RadiotherapyDepartment of PathologyThe clinical significance and potential targets of miR-150-5p have not been elucidated in nasopharyngeal carcinoma (NPC). The pooled analysis based on 539 NPC samples and 75 non-NPC nasopharyngeal samples demonstrated that the expression of miR-150-5p was down-regulated in NPC, with the area under the curve being 0.89 and the standardized mean difference being −0.66. Subsequently, we further screened the differentially expressed genes (DEGs) of 14 datasets, including 312 NPC samples and 70 non-NPC nasopharyngeal samples. After the DEGs were narrowed down with the predicted targets from the miRWalk database, 1316 prospective target genes of miR-150-5p were identified. The enrichment analysis suggested that “pathways in cancer” was the most significant pathway. Finally, six hub genes of “pathways in cancer”, including EGFR, TP53, HRAS, CCND1, CDH1, and FGF2, were screened out through the STRING database. In conclusion, the down-regulation of miR-150-5p modulates the tumorigenesis and progression of NPC.http://dx.doi.org/10.1155/2022/2485055 |
| spellingShingle | Jia-Ying Wen Gang Chen Jian-Di Li Jia-Yuan Luo Juan He Ren-Sheng Wang Li-Ting Qin Downregulated miR-150-5p in the Tissue of Nasopharyngeal Carcinoma Genetics Research |
| title | Downregulated miR-150-5p in the Tissue of Nasopharyngeal Carcinoma |
| title_full | Downregulated miR-150-5p in the Tissue of Nasopharyngeal Carcinoma |
| title_fullStr | Downregulated miR-150-5p in the Tissue of Nasopharyngeal Carcinoma |
| title_full_unstemmed | Downregulated miR-150-5p in the Tissue of Nasopharyngeal Carcinoma |
| title_short | Downregulated miR-150-5p in the Tissue of Nasopharyngeal Carcinoma |
| title_sort | downregulated mir 150 5p in the tissue of nasopharyngeal carcinoma |
| url | http://dx.doi.org/10.1155/2022/2485055 |
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