SIRT1 inactivation switches reactive astrocytes to an antiinflammatory phenotype in CNS autoimmunity

SIRT1 inactivation switches reactive astrocytes to an antiinflammatory phenotype in CNS autoimmunity

Astrocytes are highly heterogeneous in their phenotype and function, which contributes to CNS disease, repair, and aging; however, the molecular mechanism of their functional states remains largely unknown. Here, we show that activation of sirtuin 1 (SIRT1), a protein deacetylase, played an importan...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Weifeng Zhang, Dan Xiao, Xing Li, Yuan Zhang, Javad Rasouli, Giacomo Casella, Alexandra Boehm, Daniel Hwang, Larissa L.W. Ishikawa, Rodolfo Thome, Bogoljub Ciric, Mark T. Curtis, Abdolmohamad Rostami, Guang-Xian Zhang
Formáid: Alt
Teanga:English
Foilsithe / Cruthaithe: American Society for Clinical Investigation 2022-11-01
Sraith:The Journal of Clinical Investigation
Ábhair:
Autoimmunity
Inflammation
Rochtain ar líne:https://doi.org/10.1172/JCI151803

Ar líne

https://doi.org/10.1172/JCI151803

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