SIRT1 inactivation switches reactive astrocytes to an antiinflammatory phenotype in CNS autoimmunity

SIRT1 inactivation switches reactive astrocytes to an antiinflammatory phenotype in CNS autoimmunity

Astrocytes are highly heterogeneous in their phenotype and function, which contributes to CNS disease, repair, and aging; however, the molecular mechanism of their functional states remains largely unknown. Here, we show that activation of sirtuin 1 (SIRT1), a protein deacetylase, played an importan...

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Bibliographic Details
Main Authors: Weifeng Zhang, Dan Xiao, Xing Li, Yuan Zhang, Javad Rasouli, Giacomo Casella, Alexandra Boehm, Daniel Hwang, Larissa L.W. Ishikawa, Rodolfo Thome, Bogoljub Ciric, Mark T. Curtis, Abdolmohamad Rostami, Guang-Xian Zhang
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022-11-01
Series:The Journal of Clinical Investigation
Subjects:
Autoimmunity
Inflammation
Online Access:https://doi.org/10.1172/JCI151803

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