The Spectrum of Histomorphological Changes and Pathological Tumor Response following Preoperative Oral Metronomic Chemotherapy in Oral Squamous Cell Carcinoma
Abstract Sithara Aravind Background Oral metronomic chemotherapy (OMCT) represents an emerging concept in cancer treatment involving frequent administration of chemotherapeutic drugs at doses below ma...
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2022-04-01
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| Series: | South Asian Journal of Cancer |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1735592 |
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| author | Sithara Aravind Jasmin Jose Praveen Kumar Shenoy Manuprasad Avaronnan Sajith Babu Thavarool Sangeetha K. Nayanar |
| author_facet | Sithara Aravind Jasmin Jose Praveen Kumar Shenoy Manuprasad Avaronnan Sajith Babu Thavarool Sangeetha K. Nayanar |
| author_sort | Sithara Aravind |
| collection | DOAJ |
| description | Abstract
Sithara Aravind
Background Oral metronomic chemotherapy (OMCT) represents an emerging concept in cancer treatment involving frequent administration of chemotherapeutic drugs at doses below maximum tolerated doses and with no prolonged drug-free break. OMCT is being tried preoperatively in developing nations with constrained resources to prevent disease progression during the waiting period from diagnosis to surgery (bridge OMCT). The aim of the present study was to assess the spectrum of histomorphological changes and pathological tumor response following bridge OMCT in oral squamous cell carcinoma (OSCC) and to propose a new pathological response scoring system.
Materials and Methods A retrospective single-center study comprised of tissue sections of tumor proper and metastatic lymph nodes of 50, locally advanced OSCC patients treated with bridge OMCT, and had completed definitive surgery were analyzed. The present study evaluated the histomorphological features and proposed a new scoring system for pathologic tumor response. The pathologic tumor response was categorized as complete response (pCR), no response (pNR), and partial response (pPR).
Results Of the total 50 patients, 2 patients had pCR, 3 had pNR, and 45 patients had pPR as per the new proposed scoring system. Note that 96% of the cases showed no disease progression.
Conclusion Bridge OMCT is a novel treatment method that can be used to tide over the waiting period between the diagnosis and surgery in resource-constrained institutions with heavy patient load. This mode of treatment in locally advanced OSCC seems to provide promising results in this setting. Large multicentric trials are warranted to confirm these results. |
| first_indexed | 2024-04-12T03:58:18Z |
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| language | English |
| last_indexed | 2024-04-12T03:58:18Z |
| publishDate | 2022-04-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | South Asian Journal of Cancer |
| spelling | doaj.art-6a89698f47af473580ddb5b38b442cd12022-12-22T03:48:47ZengThieme Medical and Scientific Publishers Pvt. Ltd.South Asian Journal of Cancer2278-330X2278-43062022-04-01110214615110.1055/s-0041-1735592The Spectrum of Histomorphological Changes and Pathological Tumor Response following Preoperative Oral Metronomic Chemotherapy in Oral Squamous Cell CarcinomaSithara Aravind0Jasmin Jose1Praveen Kumar Shenoy2Manuprasad Avaronnan3Sajith Babu Thavarool4Sangeetha K. Nayanar5Division of Oncopathology, Malabar Cancer Centre, Thalassery, Kerala, IndiaDivision of Oncopathology, Malabar Cancer Centre, Thalassery, Kerala, IndiaDivision of Medical Oncology, Malabar Cancer Centre, Thalassery, Kerala, IndiaDivision of Medical Oncology, Malabar Cancer Centre, Thalassery, Kerala, IndiaDivision of Surgical Oncology, Malabar Cancer Centre, Thalassery, Kerala, IndiaDivision of Oncopathology, Malabar Cancer Centre, Thalassery, Kerala, IndiaAbstract Sithara Aravind Background Oral metronomic chemotherapy (OMCT) represents an emerging concept in cancer treatment involving frequent administration of chemotherapeutic drugs at doses below maximum tolerated doses and with no prolonged drug-free break. OMCT is being tried preoperatively in developing nations with constrained resources to prevent disease progression during the waiting period from diagnosis to surgery (bridge OMCT). The aim of the present study was to assess the spectrum of histomorphological changes and pathological tumor response following bridge OMCT in oral squamous cell carcinoma (OSCC) and to propose a new pathological response scoring system. Materials and Methods A retrospective single-center study comprised of tissue sections of tumor proper and metastatic lymph nodes of 50, locally advanced OSCC patients treated with bridge OMCT, and had completed definitive surgery were analyzed. The present study evaluated the histomorphological features and proposed a new scoring system for pathologic tumor response. The pathologic tumor response was categorized as complete response (pCR), no response (pNR), and partial response (pPR). Results Of the total 50 patients, 2 patients had pCR, 3 had pNR, and 45 patients had pPR as per the new proposed scoring system. Note that 96% of the cases showed no disease progression. Conclusion Bridge OMCT is a novel treatment method that can be used to tide over the waiting period between the diagnosis and surgery in resource-constrained institutions with heavy patient load. This mode of treatment in locally advanced OSCC seems to provide promising results in this setting. Large multicentric trials are warranted to confirm these results.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1735592histomorphological changesoral metronomic chemotherapyoral squamous cell carcinomapathologic tumor response |
| spellingShingle | Sithara Aravind Jasmin Jose Praveen Kumar Shenoy Manuprasad Avaronnan Sajith Babu Thavarool Sangeetha K. Nayanar The Spectrum of Histomorphological Changes and Pathological Tumor Response following Preoperative Oral Metronomic Chemotherapy in Oral Squamous Cell Carcinoma South Asian Journal of Cancer histomorphological changes oral metronomic chemotherapy oral squamous cell carcinoma pathologic tumor response |
| title | The Spectrum of Histomorphological Changes and Pathological Tumor Response following Preoperative Oral Metronomic Chemotherapy in Oral Squamous Cell Carcinoma |
| title_full | The Spectrum of Histomorphological Changes and Pathological Tumor Response following Preoperative Oral Metronomic Chemotherapy in Oral Squamous Cell Carcinoma |
| title_fullStr | The Spectrum of Histomorphological Changes and Pathological Tumor Response following Preoperative Oral Metronomic Chemotherapy in Oral Squamous Cell Carcinoma |
| title_full_unstemmed | The Spectrum of Histomorphological Changes and Pathological Tumor Response following Preoperative Oral Metronomic Chemotherapy in Oral Squamous Cell Carcinoma |
| title_short | The Spectrum of Histomorphological Changes and Pathological Tumor Response following Preoperative Oral Metronomic Chemotherapy in Oral Squamous Cell Carcinoma |
| title_sort | spectrum of histomorphological changes and pathological tumor response following preoperative oral metronomic chemotherapy in oral squamous cell carcinoma |
| topic | histomorphological changes oral metronomic chemotherapy oral squamous cell carcinoma pathologic tumor response |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1735592 |
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