Retrospective Analysis of the Effect of Lidocaine Combined with Methylprednisolone on Pain Control After Uterine Artery Embolization
BackgroundThe analgesic effect produced by the intra-arterial injection of lidocaine in patients undergoing uterine artery embolization has been proven to be safe and effective. Nevertheless, a significant degree of pain is typically experienced after the operation, and pain management is crucial. M...
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2022.875484/full |
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| author | Yi Tang Yi Tang Bin Lin Bin Lin Yan-ping Zhang Yan-ping Zhang Ya-nan Hu Ya-nan Hu Jian-hui Zhang Shao-jie Wu Shao-jie Wu Yan-feng Zhou Yan-feng Zhou Sen-lin Cai Sen-lin Cai Jie-wei Luo Jie-wei Luo Wu Chi Wu Chi Zhu-ting Fang Zhu-ting Fang |
| author_facet | Yi Tang Yi Tang Bin Lin Bin Lin Yan-ping Zhang Yan-ping Zhang Ya-nan Hu Ya-nan Hu Jian-hui Zhang Shao-jie Wu Shao-jie Wu Yan-feng Zhou Yan-feng Zhou Sen-lin Cai Sen-lin Cai Jie-wei Luo Jie-wei Luo Wu Chi Wu Chi Zhu-ting Fang Zhu-ting Fang |
| author_sort | Yi Tang |
| collection | DOAJ |
| description | BackgroundThe analgesic effect produced by the intra-arterial injection of lidocaine in patients undergoing uterine artery embolization has been proven to be safe and effective. Nevertheless, a significant degree of pain is typically experienced after the operation, and pain management is crucial. Methylprednisolone, which provides an anti-inflammatory effect, is widely used in the treatment of several diseases. To date, methylprednisolone has not been used after uterine artery embolization.MethodsA total of 131 patients with uterine leiomyoma were retrospectively enrolled. Forty-five patients (control group) were treated with embolized microspheres for bilateral uterine artery embolization. Fifty (study group) and 36 (lidocaine group) patients were administered lidocaine mixed with embolized microspheres during embolization, and in addition, the study group was administered methylprednisolone. Completed pain scales at different time points during surgery were obtained from patients undergoing uterine artery embolization. Efficacy against pain was evaluated by comparing the pain score, inflammatory index, and use of sufentanil within 24 h followed by a Kruskal-Wallis Test and a least significant difference post-hoc analysis.ResultsThe postoperative pain scores at 1, 4, and 7 h after uterine artery embolization in the study group (3.08 ± 2.09, 2.46 ± 1.93, and 2.38 ± 1.85, respectively) were significantly lower than those in the control group (4.84 ± 2.36, 4.16 ± 1.87, and 3.56 ± 1.93, respectively) and the lidocaine group (3.50 ± 2.10, 3.30 ± 1.88, and 3.28 ± 1.89, respectively). At the first 24 h after embolization, the total usage of sufentanil in the study group (31.4 ± 4.16) was significantly lower than those in the control group (45.7 ± 6.51) and the lidocaine group (38.3 ± 6.25). At 1 and 4 h, the pain scores of the lidocaine group were significantly lower than those of the control group. In addition, at the first 24 h after embolization, the total usage of sufentanil in the lidocaine group was significantly lower than that in the control group.ConclusionLidocaine in combination with methylprednisolone can significantly alleviate pain and reduce the usage of sufentanil after bilateral uterine artery embolization. Thus, methylprednisolone is a recommended addition to the therapeutic regimen after embolization. |
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| spelling | doaj.art-6a8ac0cca41d46e2b022dc1e49f9e0822022-12-22T00:46:01ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2022-04-01910.3389/fsurg.2022.875484875484Retrospective Analysis of the Effect of Lidocaine Combined with Methylprednisolone on Pain Control After Uterine Artery EmbolizationYi Tang0Yi Tang1Bin Lin2Bin Lin3Yan-ping Zhang4Yan-ping Zhang5Ya-nan Hu6Ya-nan Hu7Jian-hui Zhang8Shao-jie Wu9Shao-jie Wu10Yan-feng Zhou11Yan-feng Zhou12Sen-lin Cai13Sen-lin Cai14Jie-wei Luo15Jie-wei Luo16Wu Chi17Wu Chi18Zhu-ting Fang19Zhu-ting Fang20Department of Shengli Clinical College, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Interventional Radiology, Fujian Provincial Hospital, Fuzhou, ChinaDepartment of Shengli Clinical College, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Interventional Radiology, Fujian Provincial Hospital, Fuzhou, ChinaDepartment of Shengli Clinical College, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Interventional Radiology, Fujian Provincial Hospital, Fuzhou, ChinaDepartment of Shengli Clinical College, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Interventional Radiology, Fujian Provincial Hospital, Fuzhou, ChinaDepartment of Shengli Clinical College, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Shengli Clinical College, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Interventional Radiology, Fujian Provincial Hospital, Fuzhou, ChinaDepartment of Shengli Clinical College, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Interventional Radiology, Fujian Provincial Hospital, Fuzhou, ChinaDepartment of Shengli Clinical College, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Interventional Radiology, Fujian Provincial Hospital, Fuzhou, ChinaDepartment of Shengli Clinical College, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Traditional Chinese Medicine, Fujian Provincial Hospital, Fuzhou, ChinaDepartment of Shengli Clinical College, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, ChinaEmergency Department, Fujian Provincial Hospital, Fuzhou, ChinaDepartment of Shengli Clinical College, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, ChinaDepartment of Interventional Radiology, Fujian Provincial Hospital, Fuzhou, ChinaBackgroundThe analgesic effect produced by the intra-arterial injection of lidocaine in patients undergoing uterine artery embolization has been proven to be safe and effective. Nevertheless, a significant degree of pain is typically experienced after the operation, and pain management is crucial. Methylprednisolone, which provides an anti-inflammatory effect, is widely used in the treatment of several diseases. To date, methylprednisolone has not been used after uterine artery embolization.MethodsA total of 131 patients with uterine leiomyoma were retrospectively enrolled. Forty-five patients (control group) were treated with embolized microspheres for bilateral uterine artery embolization. Fifty (study group) and 36 (lidocaine group) patients were administered lidocaine mixed with embolized microspheres during embolization, and in addition, the study group was administered methylprednisolone. Completed pain scales at different time points during surgery were obtained from patients undergoing uterine artery embolization. Efficacy against pain was evaluated by comparing the pain score, inflammatory index, and use of sufentanil within 24 h followed by a Kruskal-Wallis Test and a least significant difference post-hoc analysis.ResultsThe postoperative pain scores at 1, 4, and 7 h after uterine artery embolization in the study group (3.08 ± 2.09, 2.46 ± 1.93, and 2.38 ± 1.85, respectively) were significantly lower than those in the control group (4.84 ± 2.36, 4.16 ± 1.87, and 3.56 ± 1.93, respectively) and the lidocaine group (3.50 ± 2.10, 3.30 ± 1.88, and 3.28 ± 1.89, respectively). At the first 24 h after embolization, the total usage of sufentanil in the study group (31.4 ± 4.16) was significantly lower than those in the control group (45.7 ± 6.51) and the lidocaine group (38.3 ± 6.25). At 1 and 4 h, the pain scores of the lidocaine group were significantly lower than those of the control group. In addition, at the first 24 h after embolization, the total usage of sufentanil in the lidocaine group was significantly lower than that in the control group.ConclusionLidocaine in combination with methylprednisolone can significantly alleviate pain and reduce the usage of sufentanil after bilateral uterine artery embolization. Thus, methylprednisolone is a recommended addition to the therapeutic regimen after embolization.https://www.frontiersin.org/articles/10.3389/fsurg.2022.875484/fullintra-arterial lidocainepain controluterine artery embolizationretrospective analysismethylprednisolone |
| spellingShingle | Yi Tang Yi Tang Bin Lin Bin Lin Yan-ping Zhang Yan-ping Zhang Ya-nan Hu Ya-nan Hu Jian-hui Zhang Shao-jie Wu Shao-jie Wu Yan-feng Zhou Yan-feng Zhou Sen-lin Cai Sen-lin Cai Jie-wei Luo Jie-wei Luo Wu Chi Wu Chi Zhu-ting Fang Zhu-ting Fang Retrospective Analysis of the Effect of Lidocaine Combined with Methylprednisolone on Pain Control After Uterine Artery Embolization Frontiers in Surgery intra-arterial lidocaine pain control uterine artery embolization retrospective analysis methylprednisolone |
| title | Retrospective Analysis of the Effect of Lidocaine Combined with Methylprednisolone on Pain Control After Uterine Artery Embolization |
| title_full | Retrospective Analysis of the Effect of Lidocaine Combined with Methylprednisolone on Pain Control After Uterine Artery Embolization |
| title_fullStr | Retrospective Analysis of the Effect of Lidocaine Combined with Methylprednisolone on Pain Control After Uterine Artery Embolization |
| title_full_unstemmed | Retrospective Analysis of the Effect of Lidocaine Combined with Methylprednisolone on Pain Control After Uterine Artery Embolization |
| title_short | Retrospective Analysis of the Effect of Lidocaine Combined with Methylprednisolone on Pain Control After Uterine Artery Embolization |
| title_sort | retrospective analysis of the effect of lidocaine combined with methylprednisolone on pain control after uterine artery embolization |
| topic | intra-arterial lidocaine pain control uterine artery embolization retrospective analysis methylprednisolone |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2022.875484/full |
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