Brain regional homogeneity and function connectivity in attenuated psychosis syndrome —based on a resting state fMRI study
Abstract Background By combining regional homogeneity (ReHo) and functional connectivity (FC) analyses, this study aimed to explore brain functional alterations in Attenuated Psychosis Syndrome (APS), which could provide complementary information for the neurophysiological indicators for schizophren...
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| Format: | Article |
| Language: | English |
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BMC
2018-12-01
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| Series: | BMC Psychiatry |
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| Online Access: | http://link.springer.com/article/10.1186/s12888-018-1954-x |
| _version_ | 1818024355971465216 |
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| author | Xiangyun Long Fei Liu Nan Huang Na Liu Jie Zhang Jing Chen Ansi Qi Xiaofeng Guan Zheng Lu |
| author_facet | Xiangyun Long Fei Liu Nan Huang Na Liu Jie Zhang Jing Chen Ansi Qi Xiaofeng Guan Zheng Lu |
| author_sort | Xiangyun Long |
| collection | DOAJ |
| description | Abstract Background By combining regional homogeneity (ReHo) and functional connectivity (FC) analyses, this study aimed to explore brain functional alterations in Attenuated Psychosis Syndrome (APS), which could provide complementary information for the neurophysiological indicators for schizophrenia (SZ) associated brain dysfunction. Methods Twenty-one APS subjects and twenty healthy controls were enrolled in the data acquisition of demographics and clinical characteristics as well as structural and resting-state functional magnetic resonance imaging (rs-fMRI). ReHo analysis was conducted to determine the peak coordinate of the abnormal regional brain activity. Then, identified brain regions were considered as seed regions and were used to calculate FC between reginal brain voxels and whole brain voxels. Finally, potential correlations between imaging indices and clinical data were also explored. Results Four APS and two HC subjects were excluded because the largest dynamic translation or rotation had exceeded 2 mm / 2°. Compared with healthy controls (HCs), APS subjects exhibited higher ReHo values in the right middle temporal gyrus (MTG) and lower ReHo values in the left middle frontal gyrus (MFG), left superior frontal gyrus (SFG), left postcentral gyrus (PoCG), and left superior frontal gyrus, medial (SFGmed). Considered these areas as seed regions, the APS subjects showed abnormal enhancement in functional brain connections, predominantly in the frontal and temporal lobes. Conclusions We concluded that the APS subjects had spatially regional dysfunction and remoted synchronous dysfunction in the frontal and temporal lobes of the brain, and changes in ReHo and FC patterns may reveal the mechanism of brain dysfunctions and may serve as an imaging biomarker for the diagnosis and evaluation of SZ. |
| first_indexed | 2024-12-10T03:58:54Z |
| format | Article |
| id | doaj.art-6a8adcad3f7b4e0686a659b3e38841a5 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-12-10T03:58:54Z |
| publishDate | 2018-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-6a8adcad3f7b4e0686a659b3e38841a52022-12-22T02:03:01ZengBMCBMC Psychiatry1471-244X2018-12-011811810.1186/s12888-018-1954-xBrain regional homogeneity and function connectivity in attenuated psychosis syndrome —based on a resting state fMRI studyXiangyun Long0Fei Liu1Nan Huang2Na Liu3Jie Zhang4Jing Chen5Ansi Qi6Xiaofeng Guan7Zheng Lu8Department of Psychiatry, Shanghai Tongji Hospital, Tongji University School of MedicineDepartment of Psychiatry, Shanghai Tongji Hospital, Tongji University School of MedicineDepartment of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of MedicineDepartment of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of MedicineDepartment of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of MedicineDepartment of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of MedicineDepartment of Psychiatry, Shanghai Tongji Hospital, Tongji University School of MedicineDepartment of Psychiatry, Shanghai Tongji Hospital, Tongji University School of MedicineDepartment of Psychiatry, Shanghai Tongji Hospital, Tongji University School of MedicineAbstract Background By combining regional homogeneity (ReHo) and functional connectivity (FC) analyses, this study aimed to explore brain functional alterations in Attenuated Psychosis Syndrome (APS), which could provide complementary information for the neurophysiological indicators for schizophrenia (SZ) associated brain dysfunction. Methods Twenty-one APS subjects and twenty healthy controls were enrolled in the data acquisition of demographics and clinical characteristics as well as structural and resting-state functional magnetic resonance imaging (rs-fMRI). ReHo analysis was conducted to determine the peak coordinate of the abnormal regional brain activity. Then, identified brain regions were considered as seed regions and were used to calculate FC between reginal brain voxels and whole brain voxels. Finally, potential correlations between imaging indices and clinical data were also explored. Results Four APS and two HC subjects were excluded because the largest dynamic translation or rotation had exceeded 2 mm / 2°. Compared with healthy controls (HCs), APS subjects exhibited higher ReHo values in the right middle temporal gyrus (MTG) and lower ReHo values in the left middle frontal gyrus (MFG), left superior frontal gyrus (SFG), left postcentral gyrus (PoCG), and left superior frontal gyrus, medial (SFGmed). Considered these areas as seed regions, the APS subjects showed abnormal enhancement in functional brain connections, predominantly in the frontal and temporal lobes. Conclusions We concluded that the APS subjects had spatially regional dysfunction and remoted synchronous dysfunction in the frontal and temporal lobes of the brain, and changes in ReHo and FC patterns may reveal the mechanism of brain dysfunctions and may serve as an imaging biomarker for the diagnosis and evaluation of SZ.http://link.springer.com/article/10.1186/s12888-018-1954-xAttenuated psychosis syndromeResting-state functional magnetic resonance imagingRegional homogeneityFunctional connectivity |
| spellingShingle | Xiangyun Long Fei Liu Nan Huang Na Liu Jie Zhang Jing Chen Ansi Qi Xiaofeng Guan Zheng Lu Brain regional homogeneity and function connectivity in attenuated psychosis syndrome —based on a resting state fMRI study BMC Psychiatry Attenuated psychosis syndrome Resting-state functional magnetic resonance imaging Regional homogeneity Functional connectivity |
| title | Brain regional homogeneity and function connectivity in attenuated psychosis syndrome —based on a resting state fMRI study |
| title_full | Brain regional homogeneity and function connectivity in attenuated psychosis syndrome —based on a resting state fMRI study |
| title_fullStr | Brain regional homogeneity and function connectivity in attenuated psychosis syndrome —based on a resting state fMRI study |
| title_full_unstemmed | Brain regional homogeneity and function connectivity in attenuated psychosis syndrome —based on a resting state fMRI study |
| title_short | Brain regional homogeneity and function connectivity in attenuated psychosis syndrome —based on a resting state fMRI study |
| title_sort | brain regional homogeneity and function connectivity in attenuated psychosis syndrome based on a resting state fmri study |
| topic | Attenuated psychosis syndrome Resting-state functional magnetic resonance imaging Regional homogeneity Functional connectivity |
| url | http://link.springer.com/article/10.1186/s12888-018-1954-x |
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