Association between <i>EGFR</i> Gene Mutation and Antioxidant Gene Polymorphism of Non-Small-Cell Lung Cancer
<i>EGFR</i> mutation status is considered as an important predictor of therapeutic responsiveness in non-small-cell lung carcinoma patients. Recent evidence suggests that antioxidant gene polymorphisms are potential predictors of lung cancer risk. Thus, stratification of <i>EGFR<...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/10/9/692 |
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| author | Ching-Hsiung Lin Po-Jen Yang Sheng-Hao Lin Kun-Tu Yeh Thomas Chang-Yao Tsao Yu-En Chen Shu-Hui Lin Shun-Fa Yang |
| author_facet | Ching-Hsiung Lin Po-Jen Yang Sheng-Hao Lin Kun-Tu Yeh Thomas Chang-Yao Tsao Yu-En Chen Shu-Hui Lin Shun-Fa Yang |
| author_sort | Ching-Hsiung Lin |
| collection | DOAJ |
| description | <i>EGFR</i> mutation status is considered as an important predictor of therapeutic responsiveness in non-small-cell lung carcinoma patients. Recent evidence suggests that antioxidant gene polymorphisms are potential predictors of lung cancer risk. Thus, stratification of <i>EGFR</i> mutation-related phenotypes by antioxidant gene polymorphism status can be an effective approach in terms of improving the prognosis of lung cancer patients. The present study was designed to evaluate the distribution frequency of antioxidant gene polymorphisms in lung adenocarcinoma, as well as its association with hotspot <i>EGFR</i> mutations. The study findings revealed that a statistically significant association exists between <i>EGFR</i> L858R mutation and AG + GG genotypes of <i>SOD</i> rs4880 polymorphism. Furthermore, the subgroup analysis data revealed that compared to AA genotype of <i>SOD</i> rs4880, AG + GG genotypes were significantly associated with advanced cancer stage and distant metastasis. Taken together, these findings can be utilized clinically to predict cancer aggressiveness, metastatic, potential and therapeutic responsiveness of lung cancer patients. |
| first_indexed | 2024-03-10T16:21:32Z |
| format | Article |
| id | doaj.art-6a8b4672fc91497aa977fb77137d2c18 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T16:21:32Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-6a8b4672fc91497aa977fb77137d2c182023-11-20T13:38:40ZengMDPI AGDiagnostics2075-44182020-09-0110969210.3390/diagnostics10090692Association between <i>EGFR</i> Gene Mutation and Antioxidant Gene Polymorphism of Non-Small-Cell Lung CancerChing-Hsiung Lin0Po-Jen Yang1Sheng-Hao Lin2Kun-Tu Yeh3Thomas Chang-Yao Tsao4Yu-En Chen5Shu-Hui Lin6Shun-Fa Yang7Division of Chest Medicine, Department of Internal Medicine, Changhua Christian Hospital, Changhua 500, TaiwanSchool of Medicine, Chung Shan Medical University, Taichung 402, TaiwanDivision of Chest Medicine, Department of Internal Medicine, Changhua Christian Hospital, Changhua 500, TaiwanSchool of Medicine, Chung Shan Medical University, Taichung 402, TaiwanSchool of Medicine, Chung Shan Medical University, Taichung 402, TaiwanDepartment of Surgical Pathology, Changhua Christian Hospital, Changhua 500, TaiwanDepartment of Surgical Pathology, Changhua Christian Hospital, Changhua 500, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan<i>EGFR</i> mutation status is considered as an important predictor of therapeutic responsiveness in non-small-cell lung carcinoma patients. Recent evidence suggests that antioxidant gene polymorphisms are potential predictors of lung cancer risk. Thus, stratification of <i>EGFR</i> mutation-related phenotypes by antioxidant gene polymorphism status can be an effective approach in terms of improving the prognosis of lung cancer patients. The present study was designed to evaluate the distribution frequency of antioxidant gene polymorphisms in lung adenocarcinoma, as well as its association with hotspot <i>EGFR</i> mutations. The study findings revealed that a statistically significant association exists between <i>EGFR</i> L858R mutation and AG + GG genotypes of <i>SOD</i> rs4880 polymorphism. Furthermore, the subgroup analysis data revealed that compared to AA genotype of <i>SOD</i> rs4880, AG + GG genotypes were significantly associated with advanced cancer stage and distant metastasis. Taken together, these findings can be utilized clinically to predict cancer aggressiveness, metastatic, potential and therapeutic responsiveness of lung cancer patients.https://www.mdpi.com/2075-4418/10/9/692adenocarcinoma<i>EGFR</i> mutationantioxidant gene polymorphisms |
| spellingShingle | Ching-Hsiung Lin Po-Jen Yang Sheng-Hao Lin Kun-Tu Yeh Thomas Chang-Yao Tsao Yu-En Chen Shu-Hui Lin Shun-Fa Yang Association between <i>EGFR</i> Gene Mutation and Antioxidant Gene Polymorphism of Non-Small-Cell Lung Cancer Diagnostics adenocarcinoma <i>EGFR</i> mutation antioxidant gene polymorphisms |
| title | Association between <i>EGFR</i> Gene Mutation and Antioxidant Gene Polymorphism of Non-Small-Cell Lung Cancer |
| title_full | Association between <i>EGFR</i> Gene Mutation and Antioxidant Gene Polymorphism of Non-Small-Cell Lung Cancer |
| title_fullStr | Association between <i>EGFR</i> Gene Mutation and Antioxidant Gene Polymorphism of Non-Small-Cell Lung Cancer |
| title_full_unstemmed | Association between <i>EGFR</i> Gene Mutation and Antioxidant Gene Polymorphism of Non-Small-Cell Lung Cancer |
| title_short | Association between <i>EGFR</i> Gene Mutation and Antioxidant Gene Polymorphism of Non-Small-Cell Lung Cancer |
| title_sort | association between i egfr i gene mutation and antioxidant gene polymorphism of non small cell lung cancer |
| topic | adenocarcinoma <i>EGFR</i> mutation antioxidant gene polymorphisms |
| url | https://www.mdpi.com/2075-4418/10/9/692 |
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