Factors Associated with Early and Late Seizure Related to Aneurysmal Subarachnoid Hemorrhage
Post-stroke epilepsy may occur after aneurysmal subarachnoid hemorrhage (aSAH). Both early and late seizures could cause severe neurocognitive deficits if administration of appropriate antiseizure medication is delayed. Therefore, it is important to elucidate the risk factors for early and late seiz...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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The Japan Neurosurgical Society
2024-03-01
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| Series: | Neurologia Medico-Chirurgica |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/nmc/64/3/64_2023-0201/_pdf/-char/en |
| _version_ | 1797223724394479616 |
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| author | Shota NAKASHIMA Hiroki NISHIBAYASHI Rie YAKO Masamichi ISHII Naotsugu TOKI Masaki TOMOBUCHI Toshihito NAKAI Hiromi YAMOTO Yoko NAKANISHI Naoyuki NAKAO |
| author_facet | Shota NAKASHIMA Hiroki NISHIBAYASHI Rie YAKO Masamichi ISHII Naotsugu TOKI Masaki TOMOBUCHI Toshihito NAKAI Hiromi YAMOTO Yoko NAKANISHI Naoyuki NAKAO |
| author_sort | Shota NAKASHIMA |
| collection | DOAJ |
| description | Post-stroke epilepsy may occur after aneurysmal subarachnoid hemorrhage (aSAH). Both early and late seizures could cause severe neurocognitive deficits if administration of appropriate antiseizure medication is delayed. Therefore, it is important to elucidate the risk factors for early and late seizures, which could be shared with medical teams to promptly manage seizures. There are aspects of both hemorrhage and ischemia in aSAH, and thus, numerous risk factors are considered for early and late seizures. We examined factors associated with aSAH-related early and late seizures. Among 297 patients who had aSAH and underwent direct or endovascular surgery, 25 had early seizures and 20 had late seizures. Patients who did not experience any seizures in at least 2-years of follow-up (n = 81) were used as the control group. Early seizures were associated with older age and acute severe nonneurological infection, whereas late seizures were associated with intraparenchymal lesion volume >10 mL and shunt placement. In patients with late seizures, consistency was frequently observed between electroencephalogram and the presence of intraparenchymal lesions. The frontopolar electrode on electroencephalogram was highly sensitive to abnormality in early seizures. Early seizures were induced by the patient's systemic factors, which may lower the threshold for cortical excitability. Patients with intraparenchymal lesions who undergo shunt placement should be carefully followed up for late seizures. |
| first_indexed | 2024-04-24T13:41:46Z |
| format | Article |
| id | doaj.art-6a8c149b03f94fe1b62965dd8ce01945 |
| institution | Directory Open Access Journal |
| issn | 1349-8029 |
| language | English |
| last_indexed | 2024-04-24T13:41:46Z |
| publishDate | 2024-03-01 |
| publisher | The Japan Neurosurgical Society |
| record_format | Article |
| series | Neurologia Medico-Chirurgica |
| spelling | doaj.art-6a8c149b03f94fe1b62965dd8ce019452024-04-04T07:49:48ZengThe Japan Neurosurgical SocietyNeurologia Medico-Chirurgica1349-80292024-03-0164312313010.2176/jns-nmc.2023-02012023-0201Factors Associated with Early and Late Seizure Related to Aneurysmal Subarachnoid HemorrhageShota NAKASHIMA0Hiroki NISHIBAYASHI1Rie YAKO2Masamichi ISHII3Naotsugu TOKI4Masaki TOMOBUCHI5Toshihito NAKAI6Hiromi YAMOTO7Yoko NAKANISHI8Naoyuki NAKAO9Department of Neurological Surgery, Wakayama Medical UniversityDepartment of Neurological Surgery, Wakayama Medical UniversityDepartment of Neurological Surgery, Wakayama Medical UniversityDepartment of Neurological Surgery, Wakayama Medical UniversityDepartment of Neurological Surgery, Wakayama Medical UniversityDepartment of Neurological Surgery, Wakayama Medical UniversityDepartment of Neurological Surgery, Wakayama Medical UniversityDepartment of Neurological Surgery, Wakayama Medical UniversityDepartment of Neurological Surgery, Wakayama Medical UniversityDepartment of Neurological Surgery, Wakayama Medical UniversityPost-stroke epilepsy may occur after aneurysmal subarachnoid hemorrhage (aSAH). Both early and late seizures could cause severe neurocognitive deficits if administration of appropriate antiseizure medication is delayed. Therefore, it is important to elucidate the risk factors for early and late seizures, which could be shared with medical teams to promptly manage seizures. There are aspects of both hemorrhage and ischemia in aSAH, and thus, numerous risk factors are considered for early and late seizures. We examined factors associated with aSAH-related early and late seizures. Among 297 patients who had aSAH and underwent direct or endovascular surgery, 25 had early seizures and 20 had late seizures. Patients who did not experience any seizures in at least 2-years of follow-up (n = 81) were used as the control group. Early seizures were associated with older age and acute severe nonneurological infection, whereas late seizures were associated with intraparenchymal lesion volume >10 mL and shunt placement. In patients with late seizures, consistency was frequently observed between electroencephalogram and the presence of intraparenchymal lesions. The frontopolar electrode on electroencephalogram was highly sensitive to abnormality in early seizures. Early seizures were induced by the patient's systemic factors, which may lower the threshold for cortical excitability. Patients with intraparenchymal lesions who undergo shunt placement should be carefully followed up for late seizures.https://www.jstage.jst.go.jp/article/nmc/64/3/64_2023-0201/_pdf/-char/enaneurysmal subarachnoid hemorrhageearly seizurelate seizureelectroencephalogram |
| spellingShingle | Shota NAKASHIMA Hiroki NISHIBAYASHI Rie YAKO Masamichi ISHII Naotsugu TOKI Masaki TOMOBUCHI Toshihito NAKAI Hiromi YAMOTO Yoko NAKANISHI Naoyuki NAKAO Factors Associated with Early and Late Seizure Related to Aneurysmal Subarachnoid Hemorrhage Neurologia Medico-Chirurgica aneurysmal subarachnoid hemorrhage early seizure late seizure electroencephalogram |
| title | Factors Associated with Early and Late Seizure Related to Aneurysmal Subarachnoid Hemorrhage |
| title_full | Factors Associated with Early and Late Seizure Related to Aneurysmal Subarachnoid Hemorrhage |
| title_fullStr | Factors Associated with Early and Late Seizure Related to Aneurysmal Subarachnoid Hemorrhage |
| title_full_unstemmed | Factors Associated with Early and Late Seizure Related to Aneurysmal Subarachnoid Hemorrhage |
| title_short | Factors Associated with Early and Late Seizure Related to Aneurysmal Subarachnoid Hemorrhage |
| title_sort | factors associated with early and late seizure related to aneurysmal subarachnoid hemorrhage |
| topic | aneurysmal subarachnoid hemorrhage early seizure late seizure electroencephalogram |
| url | https://www.jstage.jst.go.jp/article/nmc/64/3/64_2023-0201/_pdf/-char/en |
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