Role of DNA Methyl-CpG-Binding Protein MeCP2 in Rett Syndrome Pathobiology and Mechanism of Disease
Rett Syndrome (RTT) is a severe, rare, and progressive developmental disorder with patients displaying neurological regression and autism spectrum features. The affected individuals are primarily young females, and more than 95% of patients carry <i>de novo</i> mutation(s) in the Methyl-...
Main Authors: | Shervin Pejhan, Mojgan Rastegar |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-01-01
|
Series: | Biomolecules |
Subjects: | |
Online Access: | https://www.mdpi.com/2218-273X/11/1/75 |
Similar Items
-
The MeCP2E1/E2-BDNF-miR132 Homeostasis Regulatory Network Is Region-Dependent in the Human Brain and Is Impaired in Rett Syndrome Patients
by: Shervin Pejhan, et al.
Published: (2020-08-01) -
MeCP2_e2 partially compensates for lack of MeCP2_e1: A male case of Rett syndrome
by: Ryo Takeguchi, et al.
Published: (2020-02-01) -
Differential Sensitivity of the Protein Translation Initiation Machinery and mTOR Signaling to <i>MECP2</i> Gain- and Loss-of-Function Involves MeCP2 Isoform-Specific Homeostasis in the Brain
by: Marjorie Buist, et al.
Published: (2022-04-01) -
Transcriptional Regulation of <i>MECP2E1-E2</i> Isoforms and <i>BDNF</i> by Metformin and Simvastatin through Analyzing Nascent RNA Synthesis in a Human Brain Cell Line
by: Marjorie Buist, et al.
Published: (2021-08-01) -
Rett-causing mutations reveal two domains critical for MeCP2 function and for toxicity in MECP2 duplication syndrome mice
by: Laura Dean Heckman, et al.
Published: (2014-06-01)