Altered lung phospholipid metabolism in mice with targeted deletion of lysosomal-type phospholipase A21

Altered lung phospholipid metabolism in mice with targeted deletion of lysosomal-type phospholipase A21

Lung surfactant dipalmitoylphosphatidylcholine (DPPC) is endocytosed by alveolar epithelial cells and degraded by lysosomal-type phospholipase A2 (aiPLA2). This enzyme is identical to peroxiredoxin 6 (Prdx6), a bifunctional protein with PLA2 and GSH peroxidase activities. Lung phospholipid was studi...

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Bibliographic Details
Main Authors: Aron B. Fisher, Chandra Dodia, Sheldon I. Feinstein, Ye-Shih Ho
Format: Article
Language:English
Published: Elsevier 2005-06-01
Series:Journal of Lipid Research
Subjects:
peroxiredoxin 6
lung surfactant
dipalmitoylphosphatidylcholine
phospholipid remodeling
phospholipid synthesis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520330297

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