A genome-wide association study (GWAS) of the personality constructs in CPAI-2 in Taiwanese Hakka populations.
Here in this study we adopted genome-wide association studies (GWAS) to investigate the genetic components of the personality constructs in the Chinese Personality Assessment Inventory 2 (CPAI-2) in Taiwanese Hakka populations, who are likely the descendants of a recent admixture between a group of...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0281903 |
| _version_ | 1797848176548380672 |
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| author | Pei-Ying Kao Ming-Hui Chen Wei-An Chang Mei-Lin Pan Wei-Der Shu Yuh-Jyh Jong Hsien-Da Huang Cheng-Yan Wang Hong-Yan Chu Cheng-Tsung Pan Yih-Lan Liu Yeong-Shin Lin |
| author_facet | Pei-Ying Kao Ming-Hui Chen Wei-An Chang Mei-Lin Pan Wei-Der Shu Yuh-Jyh Jong Hsien-Da Huang Cheng-Yan Wang Hong-Yan Chu Cheng-Tsung Pan Yih-Lan Liu Yeong-Shin Lin |
| author_sort | Pei-Ying Kao |
| collection | DOAJ |
| description | Here in this study we adopted genome-wide association studies (GWAS) to investigate the genetic components of the personality constructs in the Chinese Personality Assessment Inventory 2 (CPAI-2) in Taiwanese Hakka populations, who are likely the descendants of a recent admixture between a group of Chinese immigrants with high emigration intention and a group of the Taiwanese aboriginal population generally without it. A total of 279 qualified participants were examined and genotyped by an Illumina array with 547,644 SNPs to perform the GWAS. Although our sample size is small and that unavoidably limits our statistical power (Type 2 error but not Type 1 error), we still found three genomic regions showing strong association with Enterprise, Diversity, and Logical vs. Affective Orientation, respectively. Multiple genes around the identified regions were reported to be nervous system related, which suggests that genetic variants underlying the certain personalities should indeed exist in the nearby areas. It is likely that the recent immigration and admixture history of the Taiwanese Hakka people created strong linkage disequilibrium between the emigration intention-related genetic variants and their neighboring genetic markers, so that we could identify them despite with only limited statistical power. |
| first_indexed | 2024-04-09T18:23:13Z |
| format | Article |
| id | doaj.art-6a915a0b1bfb48b982b3ff7018b7c458 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-09T18:23:13Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6a915a0b1bfb48b982b3ff7018b7c4582023-04-12T05:31:59ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01182e028190310.1371/journal.pone.0281903A genome-wide association study (GWAS) of the personality constructs in CPAI-2 in Taiwanese Hakka populations.Pei-Ying KaoMing-Hui ChenWei-An ChangMei-Lin PanWei-Der ShuYuh-Jyh JongHsien-Da HuangCheng-Yan WangHong-Yan ChuCheng-Tsung PanYih-Lan LiuYeong-Shin LinHere in this study we adopted genome-wide association studies (GWAS) to investigate the genetic components of the personality constructs in the Chinese Personality Assessment Inventory 2 (CPAI-2) in Taiwanese Hakka populations, who are likely the descendants of a recent admixture between a group of Chinese immigrants with high emigration intention and a group of the Taiwanese aboriginal population generally without it. A total of 279 qualified participants were examined and genotyped by an Illumina array with 547,644 SNPs to perform the GWAS. Although our sample size is small and that unavoidably limits our statistical power (Type 2 error but not Type 1 error), we still found three genomic regions showing strong association with Enterprise, Diversity, and Logical vs. Affective Orientation, respectively. Multiple genes around the identified regions were reported to be nervous system related, which suggests that genetic variants underlying the certain personalities should indeed exist in the nearby areas. It is likely that the recent immigration and admixture history of the Taiwanese Hakka people created strong linkage disequilibrium between the emigration intention-related genetic variants and their neighboring genetic markers, so that we could identify them despite with only limited statistical power.https://doi.org/10.1371/journal.pone.0281903 |
| spellingShingle | Pei-Ying Kao Ming-Hui Chen Wei-An Chang Mei-Lin Pan Wei-Der Shu Yuh-Jyh Jong Hsien-Da Huang Cheng-Yan Wang Hong-Yan Chu Cheng-Tsung Pan Yih-Lan Liu Yeong-Shin Lin A genome-wide association study (GWAS) of the personality constructs in CPAI-2 in Taiwanese Hakka populations. PLoS ONE |
| title | A genome-wide association study (GWAS) of the personality constructs in CPAI-2 in Taiwanese Hakka populations. |
| title_full | A genome-wide association study (GWAS) of the personality constructs in CPAI-2 in Taiwanese Hakka populations. |
| title_fullStr | A genome-wide association study (GWAS) of the personality constructs in CPAI-2 in Taiwanese Hakka populations. |
| title_full_unstemmed | A genome-wide association study (GWAS) of the personality constructs in CPAI-2 in Taiwanese Hakka populations. |
| title_short | A genome-wide association study (GWAS) of the personality constructs in CPAI-2 in Taiwanese Hakka populations. |
| title_sort | genome wide association study gwas of the personality constructs in cpai 2 in taiwanese hakka populations |
| url | https://doi.org/10.1371/journal.pone.0281903 |
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