An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis
Abstract Ferroptosis is a form of regulated cell death characterized by iron-dependent lipid peroxidation. This process contributes to cellular and tissue damage in various human diseases, such as cardiovascular diseases, neurodegeneration, liver disease, and cancer. Although polyunsaturated fatty a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2023-08-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-023-01077-y |
| _version_ | 1797699515195588608 |
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| author | Jong Woo Kim Ji-Yoon Lee Mihee Oh Eun-Woo Lee |
| author_facet | Jong Woo Kim Ji-Yoon Lee Mihee Oh Eun-Woo Lee |
| author_sort | Jong Woo Kim |
| collection | DOAJ |
| description | Abstract Ferroptosis is a form of regulated cell death characterized by iron-dependent lipid peroxidation. This process contributes to cellular and tissue damage in various human diseases, such as cardiovascular diseases, neurodegeneration, liver disease, and cancer. Although polyunsaturated fatty acids (PUFAs) in membrane phospholipids are preferentially oxidized, saturated/monounsaturated fatty acids (SFAs/MUFAs) also influence lipid peroxidation and ferroptosis. In this review, we first explain how cells differentially synthesize SFA/MUFAs and PUFAs and how they control fatty acid pools via fatty acid uptake and β-oxidation, impacting ferroptosis. Furthermore, we discuss how fatty acids are stored in different lipids, such as diacyl or ether phospholipids with different head groups; triglycerides; and cholesterols. Moreover, we explain how these fatty acids are released from these molecules. In summary, we provide an integrated view of the diverse and dynamic metabolic processes in the context of ferroptosis by revisiting lipidomic studies. Thus, this review contributes to the development of therapeutic strategies for ferroptosis-related diseases. |
| first_indexed | 2024-03-12T04:09:53Z |
| format | Article |
| id | doaj.art-6a92dd7449814cdba0bc5b54bfaa4a66 |
| institution | Directory Open Access Journal |
| issn | 2092-6413 |
| language | English |
| last_indexed | 2024-03-12T04:09:53Z |
| publishDate | 2023-08-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-6a92dd7449814cdba0bc5b54bfaa4a662023-09-03T11:07:17ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132023-08-015581620163110.1038/s12276-023-01077-yAn integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysisJong Woo Kim0Ji-Yoon Lee1Mihee Oh2Eun-Woo Lee3Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)Biodefense Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)Abstract Ferroptosis is a form of regulated cell death characterized by iron-dependent lipid peroxidation. This process contributes to cellular and tissue damage in various human diseases, such as cardiovascular diseases, neurodegeneration, liver disease, and cancer. Although polyunsaturated fatty acids (PUFAs) in membrane phospholipids are preferentially oxidized, saturated/monounsaturated fatty acids (SFAs/MUFAs) also influence lipid peroxidation and ferroptosis. In this review, we first explain how cells differentially synthesize SFA/MUFAs and PUFAs and how they control fatty acid pools via fatty acid uptake and β-oxidation, impacting ferroptosis. Furthermore, we discuss how fatty acids are stored in different lipids, such as diacyl or ether phospholipids with different head groups; triglycerides; and cholesterols. Moreover, we explain how these fatty acids are released from these molecules. In summary, we provide an integrated view of the diverse and dynamic metabolic processes in the context of ferroptosis by revisiting lipidomic studies. Thus, this review contributes to the development of therapeutic strategies for ferroptosis-related diseases.https://doi.org/10.1038/s12276-023-01077-y |
| spellingShingle | Jong Woo Kim Ji-Yoon Lee Mihee Oh Eun-Woo Lee An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis Experimental and Molecular Medicine |
| title | An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis |
| title_full | An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis |
| title_fullStr | An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis |
| title_full_unstemmed | An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis |
| title_short | An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis |
| title_sort | integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis |
| url | https://doi.org/10.1038/s12276-023-01077-y |
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