Exploring the Role of Serotonin as an Immune Modulatory Component in Cardiovascular Diseases
Serotonin, also known as 5-hydroxytryptamine (5-HT) is a well-known neurotransmitter in the central nervous system (CNS), but also plays a significant role in peripheral tissues. There is a growing body of evidence suggesting that serotonin influences immune cell responses and contributes to the dev...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/2/1549 |
| _version_ | 1797441216443318272 |
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| author | Aqeela Imamdin Emiel P. C. van der Vorst |
| author_facet | Aqeela Imamdin Emiel P. C. van der Vorst |
| author_sort | Aqeela Imamdin |
| collection | DOAJ |
| description | Serotonin, also known as 5-hydroxytryptamine (5-HT) is a well-known neurotransmitter in the central nervous system (CNS), but also plays a significant role in peripheral tissues. There is a growing body of evidence suggesting that serotonin influences immune cell responses and contributes to the development of pathological injury in cardiovascular diseases, such as atherosclerosis, as well as other diseases which occur as a result of immune hyperactivity. In particular, high levels of serotonin are able to activate a multitude of 5-HT receptors found on the surface of immune cells, thereby influencing the process of atherosclerotic plaque formation in arteries. In this review, we will discuss the differences between serotonin production in the CNS and the periphery, and will give a brief outline of the function of serotonin in the periphery. In this context, we will particularly focus on the effects of serotonin on immune cells related to atherosclerosis and identify caveats that are important for future research. |
| first_indexed | 2024-03-09T12:19:50Z |
| format | Article |
| id | doaj.art-6a936f5921134eb58daf556a3cf497de |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T12:19:50Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6a936f5921134eb58daf556a3cf497de2023-11-30T22:42:08ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01242154910.3390/ijms24021549Exploring the Role of Serotonin as an Immune Modulatory Component in Cardiovascular DiseasesAqeela Imamdin0Emiel P. C. van der Vorst1Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, GermanyInstitute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, GermanySerotonin, also known as 5-hydroxytryptamine (5-HT) is a well-known neurotransmitter in the central nervous system (CNS), but also plays a significant role in peripheral tissues. There is a growing body of evidence suggesting that serotonin influences immune cell responses and contributes to the development of pathological injury in cardiovascular diseases, such as atherosclerosis, as well as other diseases which occur as a result of immune hyperactivity. In particular, high levels of serotonin are able to activate a multitude of 5-HT receptors found on the surface of immune cells, thereby influencing the process of atherosclerotic plaque formation in arteries. In this review, we will discuss the differences between serotonin production in the CNS and the periphery, and will give a brief outline of the function of serotonin in the periphery. In this context, we will particularly focus on the effects of serotonin on immune cells related to atherosclerosis and identify caveats that are important for future research.https://www.mdpi.com/1422-0067/24/2/1549serotoninatherosclerosisinflammation5-HT receptors |
| spellingShingle | Aqeela Imamdin Emiel P. C. van der Vorst Exploring the Role of Serotonin as an Immune Modulatory Component in Cardiovascular Diseases International Journal of Molecular Sciences serotonin atherosclerosis inflammation 5-HT receptors |
| title | Exploring the Role of Serotonin as an Immune Modulatory Component in Cardiovascular Diseases |
| title_full | Exploring the Role of Serotonin as an Immune Modulatory Component in Cardiovascular Diseases |
| title_fullStr | Exploring the Role of Serotonin as an Immune Modulatory Component in Cardiovascular Diseases |
| title_full_unstemmed | Exploring the Role of Serotonin as an Immune Modulatory Component in Cardiovascular Diseases |
| title_short | Exploring the Role of Serotonin as an Immune Modulatory Component in Cardiovascular Diseases |
| title_sort | exploring the role of serotonin as an immune modulatory component in cardiovascular diseases |
| topic | serotonin atherosclerosis inflammation 5-HT receptors |
| url | https://www.mdpi.com/1422-0067/24/2/1549 |
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