Expression of ICOSL is associated with decreased survival in invasive breast cancer
Background Inducible co-stimulator (ICOS) is a CD28-related molecule exclusively expressed on activated T cells and plays a critical role in modulating the immune response in breast cancer. The blockage of ICOS pathway has been shown to inhibit the activity of Type 2 T helper cells, thus potentially...
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| Format: | Article |
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PeerJ Inc.
2019-05-01
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| Online Access: | https://peerj.com/articles/6903.pdf |
| _version_ | 1797424323551559680 |
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| author | Bin Wang Huayong Jiang Tingyang Zhou Ning Ma Wei Liu Yajie Wang Li Zuo |
| author_facet | Bin Wang Huayong Jiang Tingyang Zhou Ning Ma Wei Liu Yajie Wang Li Zuo |
| author_sort | Bin Wang |
| collection | DOAJ |
| description | Background Inducible co-stimulator (ICOS) is a CD28-related molecule exclusively expressed on activated T cells and plays a critical role in modulating the immune response in breast cancer. The blockage of ICOS pathway has been shown to inhibit the activity of Type 2 T helper cells, thus potentially protecting against cancer growth. The current study aims to investigate the correlation between inducible co-stimulator ligand (ICOSL) expression in tumor tissues and the prognoses of patients with invasive breast cancer. Methods Tumor samples from 562 Chinese patients with invasive breast carcinomas were collected between 2003 and 2010. The expression of ICOSL on breast tumor and adjacent non-cancerous tissue was determined via immunohistochemistry. The overall survival (OS) of patients with positive and negative ICOSL expression were described using Kaplan–Meier curves, respectively. Parametric correlation method was used to analyze the correlation between ICOSL expression and other clinicopathological parameters. ICOSL was selected as a dependent variable for multivariate analysis. Results Positive ICOSL expression was identified on the plasma membrane in both cytoplasm and the nucleus of breast cancer cells. Membrane-expressed ICOSL is determined as an independent prognostic factor for OS in breast cancer but without significantly correlating with other clinicopathologic parameters such as age, menopausal status, depth of invasion, lymph node metastasis status, histologic classification, etc. Conclusion Our study suggests that the up-regulated expression of ICOSL protein in breast tumor cells can be associated with poor prognoses in invasive breast carcinomas. |
| first_indexed | 2024-03-09T08:00:34Z |
| format | Article |
| id | doaj.art-6a9473e958014de08c78086cc0baac9c |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T08:00:34Z |
| publishDate | 2019-05-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-6a9473e958014de08c78086cc0baac9c2023-12-03T00:47:16ZengPeerJ Inc.PeerJ2167-83592019-05-017e690310.7717/peerj.6903Expression of ICOSL is associated with decreased survival in invasive breast cancerBin Wang0Huayong Jiang1Tingyang Zhou2Ning Ma3Wei Liu4Yajie Wang5Li Zuo6Department of Oncology, Changhai Hospital, the Second Military Medical University, Shanghai, ChinaDepartment of Radiation Oncology, The 7th Medical Center of PLA General Hospital, Beijing, ChinaRadiologic Sciences and Respiratory Therapy Division, School of Health and Rehabilitation Sciences, The Ohio State University College of Medicine, Columbus, OH, USAClinical Laboratory, 905th Hospital of PLA, Shanghai, ChinaDepartment of Radiation Oncology, Mayo Clinic Arizona, Pheonix, AZ, USADepartment of Oncology, Changhai Hospital, the Second Military Medical University, Shanghai, ChinaRadiologic Sciences and Respiratory Therapy Division, School of Health and Rehabilitation Sciences, The Ohio State University College of Medicine, Columbus, OH, USABackground Inducible co-stimulator (ICOS) is a CD28-related molecule exclusively expressed on activated T cells and plays a critical role in modulating the immune response in breast cancer. The blockage of ICOS pathway has been shown to inhibit the activity of Type 2 T helper cells, thus potentially protecting against cancer growth. The current study aims to investigate the correlation between inducible co-stimulator ligand (ICOSL) expression in tumor tissues and the prognoses of patients with invasive breast cancer. Methods Tumor samples from 562 Chinese patients with invasive breast carcinomas were collected between 2003 and 2010. The expression of ICOSL on breast tumor and adjacent non-cancerous tissue was determined via immunohistochemistry. The overall survival (OS) of patients with positive and negative ICOSL expression were described using Kaplan–Meier curves, respectively. Parametric correlation method was used to analyze the correlation between ICOSL expression and other clinicopathological parameters. ICOSL was selected as a dependent variable for multivariate analysis. Results Positive ICOSL expression was identified on the plasma membrane in both cytoplasm and the nucleus of breast cancer cells. Membrane-expressed ICOSL is determined as an independent prognostic factor for OS in breast cancer but without significantly correlating with other clinicopathologic parameters such as age, menopausal status, depth of invasion, lymph node metastasis status, histologic classification, etc. Conclusion Our study suggests that the up-regulated expression of ICOSL protein in breast tumor cells can be associated with poor prognoses in invasive breast carcinomas.https://peerj.com/articles/6903.pdfICOSLPrognosisInvasive breast cancer |
| spellingShingle | Bin Wang Huayong Jiang Tingyang Zhou Ning Ma Wei Liu Yajie Wang Li Zuo Expression of ICOSL is associated with decreased survival in invasive breast cancer PeerJ ICOSL Prognosis Invasive breast cancer |
| title | Expression of ICOSL is associated with decreased survival in invasive breast cancer |
| title_full | Expression of ICOSL is associated with decreased survival in invasive breast cancer |
| title_fullStr | Expression of ICOSL is associated with decreased survival in invasive breast cancer |
| title_full_unstemmed | Expression of ICOSL is associated with decreased survival in invasive breast cancer |
| title_short | Expression of ICOSL is associated with decreased survival in invasive breast cancer |
| title_sort | expression of icosl is associated with decreased survival in invasive breast cancer |
| topic | ICOSL Prognosis Invasive breast cancer |
| url | https://peerj.com/articles/6903.pdf |
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