Association of branched-chain amino acids with mortality-the Ludwigshafen Risk and Cardiovascular Health (LURIC) study
Summary: Branched-chain amino acids (BCAAs) are effectors of metabolic diseases, but their impact on mortality is largely unknown. We investigated the association of BCAA with risk factors and mortality in 2,236 participants of the Ludwigshafen Risk and Cardiovascular Health (LURIC) study using line...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223005369 |
| _version_ | 1827975050488184832 |
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| author | Angela P. Moissl Stefan Lorkowski Andreas Meinitzer Stefan Pilz Hubert Scharnagl Graciela E. Delgado Marcus E. Kleber Bernhard K. Krämer Burkert Pieske Martin R. Grübler Helmut Brussee Dirk von Lewinski Hermann Toplak Astrid Fahrleitner-Pammer Winfried März Andreas Tomaschitz |
| author_facet | Angela P. Moissl Stefan Lorkowski Andreas Meinitzer Stefan Pilz Hubert Scharnagl Graciela E. Delgado Marcus E. Kleber Bernhard K. Krämer Burkert Pieske Martin R. Grübler Helmut Brussee Dirk von Lewinski Hermann Toplak Astrid Fahrleitner-Pammer Winfried März Andreas Tomaschitz |
| author_sort | Angela P. Moissl |
| collection | DOAJ |
| description | Summary: Branched-chain amino acids (BCAAs) are effectors of metabolic diseases, but their impact on mortality is largely unknown. We investigated the association of BCAA with risk factors and mortality in 2,236 participants of the Ludwigshafen Risk and Cardiovascular Health (LURIC) study using linear and Cox regression. Adiponectin, hemoglobin, C-peptide, hemoglobin A1c, and homoarginine showed the strongest association with BCAA concentration (all p < 0.001). During a median follow-up of 10.5 years, 715 participants died, including 450 cardiovascular-related deaths. BCAA concentrations were inversely associated with the risk of all-cause and cardiovascular mortality (HR [95% CI] per 1-SD increase in log-BCAA: 0.75 [0.69–0.82] and 0.72 [0.65–0.80], respectively) after adjustment for potential confounders. BCAAs are directly associated with metabolic risk but inversely with mortality in persons with intermediate-to-high cardiovascular risk. Further studies are warranted to evaluate the diagnostic and therapeutic utility of BCAA in the context of cardiovascular diseases. |
| first_indexed | 2024-04-09T20:04:15Z |
| format | Article |
| id | doaj.art-6a953afe75424800a553f68d656a16ca |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-09T20:04:15Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-6a953afe75424800a553f68d656a16ca2023-04-02T06:14:14ZengElsevieriScience2589-00422023-04-01264106459Association of branched-chain amino acids with mortality-the Ludwigshafen Risk and Cardiovascular Health (LURIC) studyAngela P. Moissl0Stefan Lorkowski1Andreas Meinitzer2Stefan Pilz3Hubert Scharnagl4Graciela E. Delgado5Marcus E. Kleber6Bernhard K. Krämer7Burkert Pieske8Martin R. Grübler9Helmut Brussee10Dirk von Lewinski11Hermann Toplak12Astrid Fahrleitner-Pammer13Winfried März14Andreas Tomaschitz15Institute of Nutritional Sciences Friedrich Schiller University Jena, Jena, Germany; Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig, Jena, Germany; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology, Pneumology), Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyInstitute of Nutritional Sciences Friedrich Schiller University Jena, Jena, Germany; Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig, Jena, GermanyClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, AustriaMedical University of Graz, Department of Internal Medicine, Division of Endocrinology and Diabetology, Graz, AustriaClinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, AustriaVth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology, Pneumology), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Center for Preventive Medicine and Digital Health Baden-Württemberg (CPDBW), Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyCompetence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig, Jena, Germany; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology, Pneumology), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Synlab Human Genetics Laboratory, SYNLAB AG, Mannheim, GermanyVth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology, Pneumology), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Center for Preventive Medicine and Digital Health Baden-Württemberg (CPDBW), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; European Center for Angioscience ECAS, Faculty of Medicine of the University of Heidelberg, Mannheim, GermanyDepartment of Internal Medicine and Cardiology, Charitè Campus Virchow Klinikum, Berlin, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Berlin, GermanyMedical University of Graz, Department of Internal Medicine, Division of Endocrinology and Diabetology, Graz, AustriaMedical University of Graz, Department of Internal Medicine, Division of Endocrinology and Diabetology, Graz, AustriaMedical University of Graz, Department of Internal Medicine, Division of Cardiology, Graz, AustriaMedical University of Graz, Department of Internal Medicine, Division of Endocrinology and Diabetology, Graz, AustriaMedical University of Graz, Department of Internal Medicine, Division of Endocrinology and Diabetology, Graz, AustriaCompetence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig, Jena, Germany; Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology, Pneumology), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany; Corresponding authorHealth Centre Trofaiach, Trofaiach, AustriaSummary: Branched-chain amino acids (BCAAs) are effectors of metabolic diseases, but their impact on mortality is largely unknown. We investigated the association of BCAA with risk factors and mortality in 2,236 participants of the Ludwigshafen Risk and Cardiovascular Health (LURIC) study using linear and Cox regression. Adiponectin, hemoglobin, C-peptide, hemoglobin A1c, and homoarginine showed the strongest association with BCAA concentration (all p < 0.001). During a median follow-up of 10.5 years, 715 participants died, including 450 cardiovascular-related deaths. BCAA concentrations were inversely associated with the risk of all-cause and cardiovascular mortality (HR [95% CI] per 1-SD increase in log-BCAA: 0.75 [0.69–0.82] and 0.72 [0.65–0.80], respectively) after adjustment for potential confounders. BCAAs are directly associated with metabolic risk but inversely with mortality in persons with intermediate-to-high cardiovascular risk. Further studies are warranted to evaluate the diagnostic and therapeutic utility of BCAA in the context of cardiovascular diseases.http://www.sciencedirect.com/science/article/pii/S2589004223005369Health sciencesCardiovascular medicineAssociation analysis |
| spellingShingle | Angela P. Moissl Stefan Lorkowski Andreas Meinitzer Stefan Pilz Hubert Scharnagl Graciela E. Delgado Marcus E. Kleber Bernhard K. Krämer Burkert Pieske Martin R. Grübler Helmut Brussee Dirk von Lewinski Hermann Toplak Astrid Fahrleitner-Pammer Winfried März Andreas Tomaschitz Association of branched-chain amino acids with mortality-the Ludwigshafen Risk and Cardiovascular Health (LURIC) study iScience Health sciences Cardiovascular medicine Association analysis |
| title | Association of branched-chain amino acids with mortality-the Ludwigshafen Risk and Cardiovascular Health (LURIC) study |
| title_full | Association of branched-chain amino acids with mortality-the Ludwigshafen Risk and Cardiovascular Health (LURIC) study |
| title_fullStr | Association of branched-chain amino acids with mortality-the Ludwigshafen Risk and Cardiovascular Health (LURIC) study |
| title_full_unstemmed | Association of branched-chain amino acids with mortality-the Ludwigshafen Risk and Cardiovascular Health (LURIC) study |
| title_short | Association of branched-chain amino acids with mortality-the Ludwigshafen Risk and Cardiovascular Health (LURIC) study |
| title_sort | association of branched chain amino acids with mortality the ludwigshafen risk and cardiovascular health luric study |
| topic | Health sciences Cardiovascular medicine Association analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223005369 |
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