Are calcium channel blockers related to lung cancer?
Background: Calcium channel blocker (CCB) is a common antihypertensive agent for the treatment of hypertension. There are inconsistent data of an association of CCB and lung cancer in the literature. This study aimed to evaluate this association by a case-control design. Methods: The inclusion crit...
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| Format: | Article |
| Language: | English |
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AboutScience Srl
2023-05-01
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| Series: | Drug Target Insights |
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| Online Access: | https://journals.aboutscience.eu/index.php/dti/article/view/2573 |
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| author | Ratchanon Rattanathanoo Jarin Chindaprasert Watchara Boonsawat Panita Limpawattana Sittichai Khamsai Kittisak Sawanyawisuth |
| author_facet | Ratchanon Rattanathanoo Jarin Chindaprasert Watchara Boonsawat Panita Limpawattana Sittichai Khamsai Kittisak Sawanyawisuth |
| author_sort | Ratchanon Rattanathanoo |
| collection | DOAJ |
| description | Background: Calcium channel blocker (CCB) is a common antihypertensive agent for the treatment of hypertension. There are inconsistent data of an association of CCB and lung cancer in the literature. This study aimed to evaluate this association by a case-control design.
Methods: The inclusion criteria were adult patients 18 years or over, diagnosed with hypertension, lung cancer or pulmonary tuberculosis, and presenting with one of the suggestive symptoms of lung cancer. Those who were pregnant or had a diagnosis of lung cancer or pulmonary tuberculosis prior to the diagnosis of hypertension were excluded. Diagnosis of lung cancer was made pathologically, while tuberculosis was made by positive acid-fast bacilli on sputum examination, sputum culture positive for Mycobacterium tuberculosis, or polymerase chain reaction positive for M. tuberculosis with a chest x-ray compatible with tuberculosis. Cases were those diagnosed with lung cancer, while controls were those diagnosed with tuberculosis. Factors associated with lung cancer were calculated by logistic regression analysis.
Results: There were 178 patients who met the study criteria. Of those, 69 patients (38.8%) were in the case group. The lung cancer group had EGFR gene mutation in 21 patients (52.5%) and adenocarcinoma was the most common cell type of lung cancer (55 patients; 79.7%). There were two factors independently associated with lung cancer including dyslipidemia and family history of lung cancer.
Conclusions: CCB was not associated with lung cancer in patients with hypertension but dyslipidemia and family history of lung cancer were independently associated with lung cancer in this setting.
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| first_indexed | 2024-03-13T10:06:28Z |
| format | Article |
| id | doaj.art-6a999a0e3c4c4ed483c06ce5a6a1f552 |
| institution | Directory Open Access Journal |
| issn | 1177-3928 |
| language | English |
| last_indexed | 2024-03-13T10:06:28Z |
| publishDate | 2023-05-01 |
| publisher | AboutScience Srl |
| record_format | Article |
| series | Drug Target Insights |
| spelling | doaj.art-6a999a0e3c4c4ed483c06ce5a6a1f5522023-05-22T12:17:19ZengAboutScience SrlDrug Target Insights1177-39282023-05-0117110.33393/dti.2023.2573Are calcium channel blockers related to lung cancer?Ratchanon Rattanathanoo0Jarin Chindaprasert1Watchara Boonsawat2Panita Limpawattana3Sittichai Khamsai4Kittisak Sawanyawisuth5Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen - ThailandDepartment of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen - ThailandDepartment of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen - ThailandDepartment of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen - ThailandDepartment of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen - ThailandDepartment of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen - ThailandBackground: Calcium channel blocker (CCB) is a common antihypertensive agent for the treatment of hypertension. There are inconsistent data of an association of CCB and lung cancer in the literature. This study aimed to evaluate this association by a case-control design. Methods: The inclusion criteria were adult patients 18 years or over, diagnosed with hypertension, lung cancer or pulmonary tuberculosis, and presenting with one of the suggestive symptoms of lung cancer. Those who were pregnant or had a diagnosis of lung cancer or pulmonary tuberculosis prior to the diagnosis of hypertension were excluded. Diagnosis of lung cancer was made pathologically, while tuberculosis was made by positive acid-fast bacilli on sputum examination, sputum culture positive for Mycobacterium tuberculosis, or polymerase chain reaction positive for M. tuberculosis with a chest x-ray compatible with tuberculosis. Cases were those diagnosed with lung cancer, while controls were those diagnosed with tuberculosis. Factors associated with lung cancer were calculated by logistic regression analysis. Results: There were 178 patients who met the study criteria. Of those, 69 patients (38.8%) were in the case group. The lung cancer group had EGFR gene mutation in 21 patients (52.5%) and adenocarcinoma was the most common cell type of lung cancer (55 patients; 79.7%). There were two factors independently associated with lung cancer including dyslipidemia and family history of lung cancer. Conclusions: CCB was not associated with lung cancer in patients with hypertension but dyslipidemia and family history of lung cancer were independently associated with lung cancer in this setting. https://journals.aboutscience.eu/index.php/dti/article/view/2573DyslipidemiaFamily historyRisk factors |
| spellingShingle | Ratchanon Rattanathanoo Jarin Chindaprasert Watchara Boonsawat Panita Limpawattana Sittichai Khamsai Kittisak Sawanyawisuth Are calcium channel blockers related to lung cancer? Drug Target Insights Dyslipidemia Family history Risk factors |
| title | Are calcium channel blockers related to lung cancer? |
| title_full | Are calcium channel blockers related to lung cancer? |
| title_fullStr | Are calcium channel blockers related to lung cancer? |
| title_full_unstemmed | Are calcium channel blockers related to lung cancer? |
| title_short | Are calcium channel blockers related to lung cancer? |
| title_sort | are calcium channel blockers related to lung cancer |
| topic | Dyslipidemia Family history Risk factors |
| url | https://journals.aboutscience.eu/index.php/dti/article/view/2573 |
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