Clinical Characteristics of Patients with Endometrial Cancer and Adenomyosis
A better endometrial cancer (EC) prognosis in patients with coexistent adenomyosis has been reported. Unfortunately, it is still unclear if this better prognosis is related to a more favorable clinical profile of adenomyosis patients. We aimed to evaluate differences in the clinical profiles of EC p...
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MDPI AG
2021-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/19/4918 |
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| author | Paolo Casadio Antonio Raffone Manuela Maletta Antonio Travaglino Diego Raimondo Ivano Raimondo Angela Santoro Roberto Paradisi Gian Franco Zannoni Antonio Mollo Renato Seracchioli |
| author_facet | Paolo Casadio Antonio Raffone Manuela Maletta Antonio Travaglino Diego Raimondo Ivano Raimondo Angela Santoro Roberto Paradisi Gian Franco Zannoni Antonio Mollo Renato Seracchioli |
| author_sort | Paolo Casadio |
| collection | DOAJ |
| description | A better endometrial cancer (EC) prognosis in patients with coexistent adenomyosis has been reported. Unfortunately, it is still unclear if this better prognosis is related to a more favorable clinical profile of adenomyosis patients. We aimed to evaluate differences in the clinical profiles of EC patients with and without adenomyosis. A systematic review and meta-analysis was performed by searching seven electronics databases for all studies that allowed extraction of data about clinical characteristics in EC patients with and without adenomyosis. Clinical characteristics assessed were: age, Body Mass Index (BMI), premenopausal status, and nulliparity. Mean difference in mean ± standard deviation (SD) or odds ratio (OR) for clinical characteristics between EC patients with and without adenomyosis were calculated for each included study and as a pooled estimate, and graphically reported on forest plots with a 95% confidence interval (CI). The Z test was used for assessing the overall effect by considering a <i>p</i> value < 0.05 as significant. Overall, eight studies with 5681 patients were included in the qualitative analysis, and seven studies with 4366 patients in the quantitative analysis. Pooled mean difference in mean ± SD between EC women with and without adenomyosis was −1.19 (95% CI: −3.18 to 0.80; <i>p</i> = 0.24) for age, and 0.23 (95% CI: −0.62 to 1.07; <i>p</i> = 0.60) for BMI. When compared to EC women without adenomyosis, EC women with adenomyosis showed a pooled OR of 1.53 (95% CI: 0.92 to 2.54; <i>p</i> = 0.10) for premenopausal status, and of 0.60 (95% CI: 0.41 to 0.87; <i>p</i> = 0.007) for nulliparity. In conclusion, there are not significant differences in clinical characteristics between EC patients with and without adenomyosis, with the exception for nulliparity. Clinical features seem to not underlie the better EC prognosis of patients with adenomyosis compared to patients without adenomyosis. |
| first_indexed | 2024-03-10T07:04:49Z |
| format | Article |
| id | doaj.art-6a99a98c53974e9dae9e4210a0a79d98 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T07:04:49Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-6a99a98c53974e9dae9e4210a0a79d982023-11-22T15:54:19ZengMDPI AGCancers2072-66942021-09-011319491810.3390/cancers13194918Clinical Characteristics of Patients with Endometrial Cancer and AdenomyosisPaolo Casadio0Antonio Raffone1Manuela Maletta2Antonio Travaglino3Diego Raimondo4Ivano Raimondo5Angela Santoro6Roberto Paradisi7Gian Franco Zannoni8Antonio Mollo9Renato Seracchioli10Division of Gynaecology and Human Reproduction Physiopathology, Department of Medical and Surgical Sciences (DIMEC), IRCCS Azienda Ospedaliero-Univeristaria di Bologna, S. Orsola Hospital, University of Bologna, Via Massarenti 13, 40138 Bologna, ItalyDivision of Gynaecology and Human Reproduction Physiopathology, Department of Medical and Surgical Sciences (DIMEC), IRCCS Azienda Ospedaliero-Univeristaria di Bologna, S. Orsola Hospital, University of Bologna, Via Massarenti 13, 40138 Bologna, ItalyDivision of Gynaecology and Human Reproduction Physiopathology, Department of Medical and Surgical Sciences (DIMEC), IRCCS Azienda Ospedaliero-Univeristaria di Bologna, S. Orsola Hospital, University of Bologna, Via Massarenti 13, 40138 Bologna, ItalyPathology Unit, Department of Advanced Biomedical Sciences, School of Medicine, University of Naples Federico II, 80131 Naples, ItalyDivision of Gynaecology and Human Reproduction Physiopathology, Department of Medical and Surgical Sciences (DIMEC), IRCCS Azienda Ospedaliero-Univeristaria di Bologna, S. Orsola Hospital, University of Bologna, Via Massarenti 13, 40138 Bologna, ItalyGynecologic and Obstetric Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, 07100 Sassari, ItalyGynecopathology and Breast Pathology Unit, Department of Woman’s Health Science, Agostino Gemelli University Polyclinic, 00168 Rome, ItalyDivision of Gynaecology and Human Reproduction Physiopathology, Department of Medical and Surgical Sciences (DIMEC), IRCCS Azienda Ospedaliero-Univeristaria di Bologna, S. Orsola Hospital, University of Bologna, Via Massarenti 13, 40138 Bologna, ItalyGynecopathology and Breast Pathology Unit, Department of Woman’s Health Science, Agostino Gemelli University Polyclinic, 00168 Rome, ItalyGynecology and Obstetrics Unit, Department of Medicine, Surgery and Dentistry “Schola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyDivision of Gynaecology and Human Reproduction Physiopathology, Department of Medical and Surgical Sciences (DIMEC), IRCCS Azienda Ospedaliero-Univeristaria di Bologna, S. Orsola Hospital, University of Bologna, Via Massarenti 13, 40138 Bologna, ItalyA better endometrial cancer (EC) prognosis in patients with coexistent adenomyosis has been reported. Unfortunately, it is still unclear if this better prognosis is related to a more favorable clinical profile of adenomyosis patients. We aimed to evaluate differences in the clinical profiles of EC patients with and without adenomyosis. A systematic review and meta-analysis was performed by searching seven electronics databases for all studies that allowed extraction of data about clinical characteristics in EC patients with and without adenomyosis. Clinical characteristics assessed were: age, Body Mass Index (BMI), premenopausal status, and nulliparity. Mean difference in mean ± standard deviation (SD) or odds ratio (OR) for clinical characteristics between EC patients with and without adenomyosis were calculated for each included study and as a pooled estimate, and graphically reported on forest plots with a 95% confidence interval (CI). The Z test was used for assessing the overall effect by considering a <i>p</i> value < 0.05 as significant. Overall, eight studies with 5681 patients were included in the qualitative analysis, and seven studies with 4366 patients in the quantitative analysis. Pooled mean difference in mean ± SD between EC women with and without adenomyosis was −1.19 (95% CI: −3.18 to 0.80; <i>p</i> = 0.24) for age, and 0.23 (95% CI: −0.62 to 1.07; <i>p</i> = 0.60) for BMI. When compared to EC women without adenomyosis, EC women with adenomyosis showed a pooled OR of 1.53 (95% CI: 0.92 to 2.54; <i>p</i> = 0.10) for premenopausal status, and of 0.60 (95% CI: 0.41 to 0.87; <i>p</i> = 0.007) for nulliparity. In conclusion, there are not significant differences in clinical characteristics between EC patients with and without adenomyosis, with the exception for nulliparity. Clinical features seem to not underlie the better EC prognosis of patients with adenomyosis compared to patients without adenomyosis.https://www.mdpi.com/2072-6694/13/19/4918endometriummyometriumtumorcarcinomamalignancyendometriosis |
| spellingShingle | Paolo Casadio Antonio Raffone Manuela Maletta Antonio Travaglino Diego Raimondo Ivano Raimondo Angela Santoro Roberto Paradisi Gian Franco Zannoni Antonio Mollo Renato Seracchioli Clinical Characteristics of Patients with Endometrial Cancer and Adenomyosis Cancers endometrium myometrium tumor carcinoma malignancy endometriosis |
| title | Clinical Characteristics of Patients with Endometrial Cancer and Adenomyosis |
| title_full | Clinical Characteristics of Patients with Endometrial Cancer and Adenomyosis |
| title_fullStr | Clinical Characteristics of Patients with Endometrial Cancer and Adenomyosis |
| title_full_unstemmed | Clinical Characteristics of Patients with Endometrial Cancer and Adenomyosis |
| title_short | Clinical Characteristics of Patients with Endometrial Cancer and Adenomyosis |
| title_sort | clinical characteristics of patients with endometrial cancer and adenomyosis |
| topic | endometrium myometrium tumor carcinoma malignancy endometriosis |
| url | https://www.mdpi.com/2072-6694/13/19/4918 |
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