Neuromyelitis optica: phenotypic characteristics in a Brazilian case series
ABSTRACT The definition of neuromyelitis optica (NMO) is still evolving. In 2015, the International Panel for NMO Diagnosis was convened to develop revised diagnostic criteria. There have been few studies on NMO in the Brazilian population. Objective To describe the characteristics of 34 Brazilian...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000200002&lng=en&tlng=en |
| _version_ | 1818542644959117312 |
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| author | Maria Cristina Del Negro Patricia Beatriz Christino Marinho Regina Maria Papais-Alvarenga |
| author_facet | Maria Cristina Del Negro Patricia Beatriz Christino Marinho Regina Maria Papais-Alvarenga |
| author_sort | Maria Cristina Del Negro |
| collection | DOAJ |
| description | ABSTRACT The definition of neuromyelitis optica (NMO) is still evolving. In 2015, the International Panel for NMO Diagnosis was convened to develop revised diagnostic criteria. There have been few studies on NMO in the Brazilian population. Objective To describe the characteristics of 34 Brazilian NMO patients. To evaluate the contribution of the 2015 criteria to the diagnosis of NMO spectrum disorders (NMOSD) in 40 patients with longitudinal extensive transverse myelitis (LEMT). Methods This is a retrospective, descriptive and analytic study. Results Among NMO patients, there was a predominance of women, with onset in the fourth decade of life, and AQP4-IgG seropositivity in 73.5%. The diagnosis of NMOSD was established in 37.5% of LETM patients according to AQP4-IgG positivity and in 5% of LETM patients if the AQP4-IgG result was unknown. Conclusions The characteristics of this series are similar to those of other Western populations. The AQP4-IgG testing assists in the diagnosis of NMOSD. |
| first_indexed | 2024-12-11T22:24:49Z |
| format | Article |
| id | doaj.art-6a9b4fcc2435463396ad1d31182402be |
| institution | Directory Open Access Journal |
| issn | 1678-4227 |
| language | English |
| last_indexed | 2024-12-11T22:24:49Z |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-6a9b4fcc2435463396ad1d31182402be2022-12-22T00:48:18ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-4227752818610.1590/0004-282x20160193S0004-282X2017000200002Neuromyelitis optica: phenotypic characteristics in a Brazilian case seriesMaria Cristina Del NegroPatricia Beatriz Christino MarinhoRegina Maria Papais-AlvarengaABSTRACT The definition of neuromyelitis optica (NMO) is still evolving. In 2015, the International Panel for NMO Diagnosis was convened to develop revised diagnostic criteria. There have been few studies on NMO in the Brazilian population. Objective To describe the characteristics of 34 Brazilian NMO patients. To evaluate the contribution of the 2015 criteria to the diagnosis of NMO spectrum disorders (NMOSD) in 40 patients with longitudinal extensive transverse myelitis (LEMT). Methods This is a retrospective, descriptive and analytic study. Results Among NMO patients, there was a predominance of women, with onset in the fourth decade of life, and AQP4-IgG seropositivity in 73.5%. The diagnosis of NMOSD was established in 37.5% of LETM patients according to AQP4-IgG positivity and in 5% of LETM patients if the AQP4-IgG result was unknown. Conclusions The characteristics of this series are similar to those of other Western populations. The AQP4-IgG testing assists in the diagnosis of NMOSD.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000200002&lng=en&tlng=enneuromielite ópticaepidemiologiaestudo transversalensaio enzimático |
| spellingShingle | Maria Cristina Del Negro Patricia Beatriz Christino Marinho Regina Maria Papais-Alvarenga Neuromyelitis optica: phenotypic characteristics in a Brazilian case series Arquivos de Neuro-Psiquiatria neuromielite óptica epidemiologia estudo transversal ensaio enzimático |
| title | Neuromyelitis optica: phenotypic characteristics in a Brazilian case series |
| title_full | Neuromyelitis optica: phenotypic characteristics in a Brazilian case series |
| title_fullStr | Neuromyelitis optica: phenotypic characteristics in a Brazilian case series |
| title_full_unstemmed | Neuromyelitis optica: phenotypic characteristics in a Brazilian case series |
| title_short | Neuromyelitis optica: phenotypic characteristics in a Brazilian case series |
| title_sort | neuromyelitis optica phenotypic characteristics in a brazilian case series |
| topic | neuromielite óptica epidemiologia estudo transversal ensaio enzimático |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2017000200002&lng=en&tlng=en |
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