The DEAD/DEAH Box Helicase, DDX11, Is Essential for the Survival of Advanced Clear Cell Renal Cell Carcinoma and Is a Determinant of PARP Inhibitor Sensitivity

The DEAD/DEAH Box Helicase, DDX11, Is Essential for the Survival of Advanced Clear Cell Renal Cell Carcinoma and Is a Determinant of PARP Inhibitor Sensitivity

Genes associated with the DEAD-box helicase <i>DDX11</i> are significant biomarkers of aggressive renal cell carcinoma (RCC), but their molecular function is poorly understood. We analyzed the molecular pathways through which DDX11 is involved in RCC cell survival and poly (ADP-ribose) p...

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Bibliographic Details
Main Authors: Jee Soo Park, Myung Eun Lee, Won Sik Jang, Koon Ho Rha, Seung Hwan Lee, Jongsoo Lee, Won Sik Ham
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
renal cell carcinoma
DDX11
PARP inhibitor
olaparib
sunitinib
786-O
Online Access:https://www.mdpi.com/2072-6694/13/11/2574

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