Alcohol-specific transcriptional dynamics of memory reconsolidation and relapse
Abstract Relapse, a critical issue in alcohol addiction, can be attenuated by disruption of alcohol-associated memories. Memories are thought to temporarily destabilize upon retrieval during the reconsolidation process. Here, we provide evidence for unique transcriptional dynamics underpinning alcoh...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-02-01
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| Series: | Translational Psychiatry |
| Online Access: | https://doi.org/10.1038/s41398-023-02352-2 |
| _version_ | 1797863465376808960 |
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| author | Koral Goltseker Patricia Garay Katherine Bonefas Shigeki Iwase Segev Barak |
| author_facet | Koral Goltseker Patricia Garay Katherine Bonefas Shigeki Iwase Segev Barak |
| author_sort | Koral Goltseker |
| collection | DOAJ |
| description | Abstract Relapse, a critical issue in alcohol addiction, can be attenuated by disruption of alcohol-associated memories. Memories are thought to temporarily destabilize upon retrieval during the reconsolidation process. Here, we provide evidence for unique transcriptional dynamics underpinning alcohol memory reconsolidation. Using a mouse place-conditioning procedure, we show that alcohol-memory retrieval increases the mRNA expression of immediate-early genes in the dorsal hippocampus and medial prefrontal cortex, and that alcohol seeking is abolished by post-retrieval non-specific inhibition of gene transcription, or by downregulating ARC expression using antisense-oligodeoxynucleotides. However, since retrieval of memories for a natural reward (sucrose) also increased the same immediate-early gene expression, we explored for alcohol-specific transcriptional changes using RNA-sequencing. We revealed a unique transcriptional fingerprint activated by alcohol memories, as the expression of this set of plasticity-related genes was not altered by sucrose-memory retrieval. Our results suggest that alcohol memories may activate two parallel transcription programs: one is involved in memory reconsolidation in general, and another is specifically activated during alcohol-memory processing. |
| first_indexed | 2024-04-09T22:36:01Z |
| format | Article |
| id | doaj.art-6a9c7d0eaf6f4ff4af66149f1da8c338 |
| institution | Directory Open Access Journal |
| issn | 2158-3188 |
| language | English |
| last_indexed | 2024-04-09T22:36:01Z |
| publishDate | 2023-02-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Translational Psychiatry |
| spelling | doaj.art-6a9c7d0eaf6f4ff4af66149f1da8c3382023-03-22T12:27:07ZengNature Publishing GroupTranslational Psychiatry2158-31882023-02-0113111210.1038/s41398-023-02352-2Alcohol-specific transcriptional dynamics of memory reconsolidation and relapseKoral Goltseker0Patricia Garay1Katherine Bonefas2Shigeki Iwase3Segev Barak4School of Psychological Sciences, Tel Aviv UniversityThe University of Michigan Neuroscience Graduate ProgramThe University of Michigan Neuroscience Graduate ProgramThe University of Michigan Neuroscience Graduate ProgramSchool of Psychological Sciences, Tel Aviv UniversityAbstract Relapse, a critical issue in alcohol addiction, can be attenuated by disruption of alcohol-associated memories. Memories are thought to temporarily destabilize upon retrieval during the reconsolidation process. Here, we provide evidence for unique transcriptional dynamics underpinning alcohol memory reconsolidation. Using a mouse place-conditioning procedure, we show that alcohol-memory retrieval increases the mRNA expression of immediate-early genes in the dorsal hippocampus and medial prefrontal cortex, and that alcohol seeking is abolished by post-retrieval non-specific inhibition of gene transcription, or by downregulating ARC expression using antisense-oligodeoxynucleotides. However, since retrieval of memories for a natural reward (sucrose) also increased the same immediate-early gene expression, we explored for alcohol-specific transcriptional changes using RNA-sequencing. We revealed a unique transcriptional fingerprint activated by alcohol memories, as the expression of this set of plasticity-related genes was not altered by sucrose-memory retrieval. Our results suggest that alcohol memories may activate two parallel transcription programs: one is involved in memory reconsolidation in general, and another is specifically activated during alcohol-memory processing.https://doi.org/10.1038/s41398-023-02352-2 |
| spellingShingle | Koral Goltseker Patricia Garay Katherine Bonefas Shigeki Iwase Segev Barak Alcohol-specific transcriptional dynamics of memory reconsolidation and relapse Translational Psychiatry |
| title | Alcohol-specific transcriptional dynamics of memory reconsolidation and relapse |
| title_full | Alcohol-specific transcriptional dynamics of memory reconsolidation and relapse |
| title_fullStr | Alcohol-specific transcriptional dynamics of memory reconsolidation and relapse |
| title_full_unstemmed | Alcohol-specific transcriptional dynamics of memory reconsolidation and relapse |
| title_short | Alcohol-specific transcriptional dynamics of memory reconsolidation and relapse |
| title_sort | alcohol specific transcriptional dynamics of memory reconsolidation and relapse |
| url | https://doi.org/10.1038/s41398-023-02352-2 |
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