High tumor hexokinase-2 expression promotes a pro-tumorigenic immune microenvironment by modulating CD8+/regulatory T-cell infiltration

High tumor hexokinase-2 expression promotes a pro-tumorigenic immune microenvironment by modulating CD8+/regulatory T-cell infiltration

Abstract Background Relationship between cancer cell glycolysis and the landscape of tumor immune microenvironment in human cancers was investigated. Methods Forty-one fresh lung adenocarcinoma (ADC) tissues were analyzed using flow cytometry for comprehensive immunoprofiling. Formalin-fixed tissues...

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Bibliographic Details
Main Authors:	Sehui Kim, Jaemoon Koh, Seung Geun Song, Jeemin Yim, Miso Kim, Bhumsuk Keam, Young Tae Kim, Jihun Kim, Doo Hyun Chung, Yoon Kyung Jeon
Format:	Article
Language:	English
Published:	BMC 2022-11-01
Series:	BMC Cancer
Subjects:	Hexokinase-2 Glycolysis Tumor microenvironment Tumor-infiltrating lymphocytes CD8 + T-cell to Treg ratio Immunotherapy
Online Access:	https://doi.org/10.1186/s12885-022-10239-6

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