SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir.

SARS-CoV-2 infects human brain organoids causing cell death and loss of synapses that can be rescued by treatment with Sofosbuvir.

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The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which was rapidly declared a pandemic by the World Health Organization (WHO). Early clinical symptomatology focused mainly on respiratory illnesses. However, a variety of n...

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Bibliographic Details
Main Authors: Pinar Mesci, Janaina S de Souza, Laura Martin-Sancho, Angela Macia, Aurian Saleh, Xin Yin, Cedric Snethlage, Jason W Adams, Simoni H Avansini, Roberto H Herai, Angels Almenar-Queralt, Yuan Pu, Ryan A Szeto, Gabriela Goldberg, Patrick T Bruck, Fabio Papes, Sumit K Chanda, Alysson R Muotri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-11-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001845

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