Compounds that modulate AMPK activity and hepatic steatosis impact the biosynthesis of microRNAs required to maintain lipid homeostasis in hepatocytes

Compounds that modulate AMPK activity and hepatic steatosis impact the biosynthesis of microRNAs required to maintain lipid homeostasis in hepatocytes

Background: While the impact of metformin in hepatocytes leads to fatty acid (FA) oxidation and decreased lipogenesis, hepatic microRNAs (miRNAs) have been associated with fat overload and impaired metabolism, contributing to the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Methods: We...

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Main Authors: Jèssica Latorre, Francisco J. Ortega, Laura Liñares-Pose, José M. Moreno-Navarrete, Aina Lluch, Ferran Comas, Núria Oliveras-Cañellas, Wifredo Ricart, Marcus Höring, You Zhou, Gerhard Liebisch, P.A. Nidhina Haridas, Vesa M. Olkkonen, Miguel López, José M. Fernández-Real
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420300724

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