Physicochemical stability of urea-containing Mitomycin C preparations in glass vials (1.0 mg/mL) and plastic syringes (2.0, 0.4, 0.2 mg/mL)

Physicochemical stability of urea-containing Mitomycin C preparations in glass vials (1.0 mg/mL) and plastic syringes (2.0, 0.4, 0.2 mg/mL)

To date, there is only one study investigating the physicochemical stability of diluted mitomycin (MMC) solutions prepared by using urea-containing Mitomycin medac as starting material. The aim of the study was to test the solubility of the new MMC formulation with regard to highly concentrated solu...

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Bibliographic Details
Main Authors: Almasi Jannik, Erdnüß Frank, Thiesen Judith, Krämer Irene
Format: Article
Language:English
Published: De Gruyter 2023-07-01
Series:Pharmaceutical Technology in Hospital Pharmacy
Subjects:
high-performance liquid chromatography (hplc) assay
mitomycin c
physicochemical stability
plastic syringes
solubility
urea-containing formulation
Online Access:https://doi.org/10.1515/pthp-2023-0003
Description
Summary:To date, there is only one study investigating the physicochemical stability of diluted mitomycin (MMC) solutions prepared by using urea-containing Mitomycin medac as starting material. The aim of the study was to test the solubility of the new MMC formulation with regard to highly concentrated solutions and determine the physicochemical stability of clinically relevant MMC concentrations stored under different conditions in various primary containers.
ISSN:2365-2411
2365-242X

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