Physicochemical stability of urea-containing Mitomycin C preparations in glass vials (1.0 mg/mL) and plastic syringes (2.0, 0.4, 0.2 mg/mL)
To date, there is only one study investigating the physicochemical stability of diluted mitomycin (MMC) solutions prepared by using urea-containing Mitomycin medac as starting material. The aim of the study was to test the solubility of the new MMC formulation with regard to highly concentrated solu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2023-07-01
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| Series: | Pharmaceutical Technology in Hospital Pharmacy |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/pthp-2023-0003 |
| _version_ | 1797778374458867712 |
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| author | Almasi Jannik Erdnüß Frank Thiesen Judith Krämer Irene |
| author_facet | Almasi Jannik Erdnüß Frank Thiesen Judith Krämer Irene |
| author_sort | Almasi Jannik |
| collection | DOAJ |
| description | To date, there is only one study investigating the physicochemical stability of diluted mitomycin (MMC) solutions prepared by using urea-containing Mitomycin medac as starting material. The aim of the study was to test the solubility of the new MMC formulation with regard to highly concentrated solutions and determine the physicochemical stability of clinically relevant MMC concentrations stored under different conditions in various primary containers. |
| first_indexed | 2024-03-12T23:16:25Z |
| format | Article |
| id | doaj.art-6aa297c459ea4dd58ff643696b29b80c |
| institution | Directory Open Access Journal |
| issn | 2365-2411 2365-242X |
| language | English |
| last_indexed | 2024-03-12T23:16:25Z |
| publishDate | 2023-07-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Pharmaceutical Technology in Hospital Pharmacy |
| spelling | doaj.art-6aa297c459ea4dd58ff643696b29b80c2023-07-17T05:25:53ZengDe GruyterPharmaceutical Technology in Hospital Pharmacy2365-24112365-242X2023-07-01817091910.1515/pthp-2023-0003Physicochemical stability of urea-containing Mitomycin C preparations in glass vials (1.0 mg/mL) and plastic syringes (2.0, 0.4, 0.2 mg/mL)Almasi Jannik0Erdnüß Frank1Thiesen Judith2Krämer Irene3Department of Pharmacy, University Medical Center, Johannes Gutenberg-University, Mainz, GermanyDepartment of Pharmacy, University Medical Center, Johannes Gutenberg-University, Mainz, GermanyDepartment of Pharmacy, University Medical Center, Johannes Gutenberg-University, Mainz, GermanyDepartment of Pharmacy, University Medical Center, Johannes Gutenberg-University, Mainz, GermanyTo date, there is only one study investigating the physicochemical stability of diluted mitomycin (MMC) solutions prepared by using urea-containing Mitomycin medac as starting material. The aim of the study was to test the solubility of the new MMC formulation with regard to highly concentrated solutions and determine the physicochemical stability of clinically relevant MMC concentrations stored under different conditions in various primary containers.https://doi.org/10.1515/pthp-2023-0003high-performance liquid chromatography (hplc) assaymitomycin cphysicochemical stabilityplastic syringessolubilityurea-containing formulation |
| spellingShingle | Almasi Jannik Erdnüß Frank Thiesen Judith Krämer Irene Physicochemical stability of urea-containing Mitomycin C preparations in glass vials (1.0 mg/mL) and plastic syringes (2.0, 0.4, 0.2 mg/mL) Pharmaceutical Technology in Hospital Pharmacy high-performance liquid chromatography (hplc) assay mitomycin c physicochemical stability plastic syringes solubility urea-containing formulation |
| title | Physicochemical stability of urea-containing Mitomycin C preparations in glass vials (1.0 mg/mL) and plastic syringes (2.0, 0.4, 0.2 mg/mL) |
| title_full | Physicochemical stability of urea-containing Mitomycin C preparations in glass vials (1.0 mg/mL) and plastic syringes (2.0, 0.4, 0.2 mg/mL) |
| title_fullStr | Physicochemical stability of urea-containing Mitomycin C preparations in glass vials (1.0 mg/mL) and plastic syringes (2.0, 0.4, 0.2 mg/mL) |
| title_full_unstemmed | Physicochemical stability of urea-containing Mitomycin C preparations in glass vials (1.0 mg/mL) and plastic syringes (2.0, 0.4, 0.2 mg/mL) |
| title_short | Physicochemical stability of urea-containing Mitomycin C preparations in glass vials (1.0 mg/mL) and plastic syringes (2.0, 0.4, 0.2 mg/mL) |
| title_sort | physicochemical stability of urea containing mitomycin c preparations in glass vials 1 0 mg ml and plastic syringes 2 0 0 4 0 2 mg ml |
| topic | high-performance liquid chromatography (hplc) assay mitomycin c physicochemical stability plastic syringes solubility urea-containing formulation |
| url | https://doi.org/10.1515/pthp-2023-0003 |
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